SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		3 / 3 SER A  44
VAL A 124
LEU A  96
 SER  A  44 ( 0.0A)
VAL  A 124 ( 0.6A)
LEU  A  96 ( 0.6A)
 0.62A 1yajG-3c3nA:
2.3		 1yajG-3c3nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ASN A 129
ARG A  52
GLY A  22
SER A  26
 ASN  A 129 (-0.6A)
ARG  A  52 ( 0.6A)
GLY  A  22 (-0.0A)
SER  A  26 ( 0.0A)
 0.77A 4cp3A-3c3nA:
undetectable
4cp3B-3c3nA:
undetectable		 4cp3A-3c3nA:
20.77
4cp3B-3c3nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 8 GLU A 304
GLU A 305
GLY A 266
ARG A 307
 GLU  A 304 ( 0.6A)
GLU  A 305 ( 0.6A)
GLY  A 266 ( 0.0A)
ARG  A 307 ( 0.6A)
 1.03A 4fgzA-3c3nA:
undetectable
4fgzB-3c3nA:
undetectable		 4fgzA-3c3nA:
22.15
4fgzB-3c3nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 8 PHE A  13
GLN A 271
GLY A 249
THR A 193
 PHE  A  13 ( 1.3A)
GLN  A 271 ( 0.6A)
GLY  A 249 ( 0.0A)
THR  A 193 ( 0.8A)
 0.99A 4k87A-3c3nA:
undetectable		 4k87A-3c3nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 251
GLY A 252
GLY A 224
ALA A 231
HIS A 262
 GLY  A 251 (-0.0A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
ALA  A 231 ( 0.0A)
HIS  A 262 ( 1.0A)
 1.16A 4l8fB-3c3nA:
undetectable		 4l8fB-3c3nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 251
GLY A 252
GLY A 224
ALA A 231
HIS A 262
 GLY  A 251 (-0.0A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
ALA  A 231 ( 0.0A)
HIS  A 262 ( 1.0A)
 1.15A 4l8fD-3c3nA:
undetectable		 4l8fD-3c3nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ALA A  14
ARG A 286
GLY A 282
GLU A 279
 ALA  A  14 ( 0.0A)
ARG  A 286 ( 0.6A)
GLY  A 282 ( 0.0A)
GLU  A 279 ( 0.5A)
 0.86A 5bs8A-3c3nA:
undetectable
5bs8C-3c3nA:
undetectable
5bs8D-3c3nA:
undetectable		 5bs8A-3c3nA:
20.95
5bs8C-3c3nA:
20.95
5bs8D-3c3nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ALA A  14
ARG A 286
GLY A 282
GLU A 279
 ALA  A  14 ( 0.0A)
ARG  A 286 ( 0.6A)
GLY  A 282 ( 0.0A)
GLU  A 279 ( 0.5A)
 0.85A 5bs8A-3c3nA:
undetectable
5bs8B-3c3nA:
undetectable
5bs8C-3c3nA:
undetectable		 5bs8A-3c3nA:
20.95
5bs8B-3c3nA:
21.00
5bs8C-3c3nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ALA A  14
ARG A 286
GLY A 282
GLU A 279
 ALA  A  14 ( 0.0A)
ARG  A 286 ( 0.6A)
GLY  A 282 ( 0.0A)
GLU  A 279 ( 0.5A)
 0.88A 5btdA-3c3nA:
undetectable
5btdB-3c3nA:
undetectable
5btdC-3c3nA:
undetectable		 5btdA-3c3nA:
20.95
5btdB-3c3nA:
21.00
5btdC-3c3nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ALA A  14
ARG A 286
GLY A 282
GLU A 279
 ALA  A  14 ( 0.0A)
ARG  A 286 ( 0.6A)
GLY  A 282 ( 0.0A)
GLU  A 279 ( 0.5A)
 0.89A 5btdA-3c3nA:
undetectable
5btdC-3c3nA:
undetectable
5btdD-3c3nA:
undetectable		 5btdA-3c3nA:
20.95
5btdC-3c3nA:
20.95
5btdD-3c3nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 ALA A  14
ARG A 286
GLY A 282
GLU A 279
 ALA  A  14 ( 0.0A)
ARG  A 286 ( 0.6A)
GLY  A 282 ( 0.0A)
GLU  A 279 ( 0.5A)
 0.89A 5btgA-3c3nA:
undetectable
5btgB-3c3nA:
undetectable
5btgC-3c3nA:
undetectable		 5btgA-3c3nA:
20.95
5btgB-3c3nA:
21.00
5btgC-3c3nA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ALA A  14
ARG A 286
GLY A 282
GLU A 279
 ALA  A  14 ( 0.0A)
ARG  A 286 ( 0.6A)
GLY  A 282 ( 0.0A)
GLU  A 279 ( 0.5A)
 0.92A 5btgA-3c3nA:
undetectable
5btgC-3c3nA:
undetectable
5btgD-3c3nA:
undetectable		 5btgA-3c3nA:
20.95
5btgC-3c3nA:
20.95
5btgD-3c3nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  73
SER A  99
GLU A 127
SER A  67
GLY A 224
 LEU  A  73 (-0.6A)
SER  A  99 ( 0.0A)
GLU  A 127 ( 0.5A)
SER  A  67 ( 0.0A)
GLY  A 224 (-0.0A)
 1.34A 5f9zB-3c3nA:
undetectable		 5f9zB-3c3nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 7 ILE A 227
GLY A 224
PHE A  17
ASP A 258
 ILE  A 227 (-0.4A)
GLY  A 224 (-0.0A)
PHE  A  17 ( 1.3A)
ASP  A 258 ( 0.5A)
 0.98A 5hieA-3c3nA:
undetectable		 5hieA-3c3nA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 254
GLU A 257
GLY A 252
GLY A 224
 TYR  A 254 ( 1.3A)
GLU  A 257 ( 0.5A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
 0.94A 5x7pB-3c3nA:
undetectable		 5x7pB-3c3nA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 159
PHE A  78
ILE A 100
LEU A  98
ALA A 116
 TYR  A 159 ( 1.3A)
PHE  A  78 ( 1.3A)
ILE  A 100 ( 0.6A)
LEU  A  98 ( 0.6A)
ALA  A 116 ( 0.0A)
 1.37A 5zwrB-3c3nA:
undetectable		 5zwrB-3c3nA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 306
VAL A 270
LEU A   6
LEU A 303
 PHE  A 306 ( 1.3A)
VAL  A 270 ( 0.6A)
LEU  A   6 ( 0.6A)
LEU  A 303 ( 0.6A)
 1.03A 6e43A-3c3nA:
undetectable		 6e43A-3c3nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 306
VAL A 270
LEU A   6
LEU A 303
 PHE  A 306 ( 1.3A)
VAL  A 270 ( 0.6A)
LEU  A   6 ( 0.6A)
LEU  A 303 ( 0.6A)
 1.02A 6e43C-3c3nA:
undetectable		 6e43C-3c3nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 ASN A 234
TYR A 170
VAL A 195
VAL A 198
 ASN  A 234 ( 0.6A)
TYR  A 170 (-1.3A)
VAL  A 195 (-0.6A)
VAL  A 198 ( 0.6A)
 1.27A 6f32B-3c3nA:
undetectable		 6f32B-3c3nA:
21.74