SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
3 / 3 PRO A  62
ASP A  87
ASP A 115
None
EDO  A 215 (-3.0A)
None
0.72A 1sqfA-3c3pA:
10.7
1sqfA-3c3pA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 7 ASP A 134
VAL A 158
GLY A  65
ILE A  36
None
None
EDO  A 215 ( 4.2A)
None
0.83A 1t7iB-3c3pA:
undetectable
1t7iB-3c3pA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 8 LEU A 142
GLY A 138
LEU A 155
PRO A  62
None
0.78A 1ya4A-3c3pA:
undetectable
1ya4A-3c3pA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 7 LEU A 142
GLY A 138
LEU A 155
PRO A  62
None
0.76A 1ya4B-3c3pA:
undetectable
1ya4B-3c3pA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 6 LEU A 142
LEU A 149
PRO A  62
VAL A  60
None
0.95A 2dqyC-3c3pA:
undetectable
2dqyC-3c3pA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
3 / 3 ASP A  87
ASP A 115
ASP A 132
EDO  A 215 (-3.0A)
None
None
0.50A 2igtA-3c3pA:
15.0
2igtA-3c3pA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
3 / 3 ASP A  87
ASP A 115
ASP A 132
EDO  A 215 (-3.0A)
None
None
0.54A 2igtB-3c3pA:
15.1
2igtB-3c3pA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
5 / 5 PRO A  62
ALA A 120
ASP A  87
ASP A  91
ASP A 115
None
None
EDO  A 215 (-3.0A)
EDO  A 216 (-3.6A)
None
1.03A 2nyuB-3c3pA:
12.5
2nyuB-3c3pA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 8 PHE A 130
ILE A 156
PHE A  73
VAL A 202
None
0.90A 3me6B-3c3pA:
undetectable
3me6B-3c3pA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 8 ASP A 134
VAL A 158
GLY A  65
ILE A  36
None
None
EDO  A 215 ( 4.2A)
None
0.76A 3nu9A-3c3pA:
undetectable
3nu9A-3c3pA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 8 ARG A 163
ALA A 160
LEU A 203
ASP A 132
EDO  A 217 ( 4.4A)
None
None
None
0.90A 3qj7A-3c3pA:
undetectable
3qj7D-3c3pA:
undetectable
3qj7A-3c3pA:
23.74
3qj7D-3c3pA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
5 / 12 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
None
0.94A 3sudB-3c3pA:
undetectable
3sudB-3c3pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
5 / 12 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
None
0.97A 3sudC-3c3pA:
undetectable
3sudC-3c3pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
5 / 12 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
None
1.01A 3sueA-3c3pA:
undetectable
3sueA-3c3pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
5 / 12 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
None
0.93A 3sufD-3c3pA:
undetectable
3sufD-3c3pA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 5 ASP A 134
VAL A  39
ASP A  40
GLY A 199
None
1.25A 4xp6A-3c3pA:
undetectable
4xp6A-3c3pA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)
3c3p METHYLTRANSFERASE
(Geobacter
sulfurreducens)
4 / 4 VAL A 198
GLY A 201
ARG A 162
VAL A   5
None
None
None
EDO  A 213 (-4.2A)
1.49A 5d4nA-3c3pA:
undetectable
5d4nB-3c3pA:
undetectable
5d4nA-3c3pA:
18.27
5d4nB-3c3pA:
18.27