SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  79
ALA A  51
LEU A  76
ILE A 106
LEU A  65
 None
 1.23A 1g50A-3c3wA:
undetectable		 1g50A-3c3wA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		3 / 3 LEU A   6
LEU A  53
MET A  90
 None
 0.53A 1ya3B-3c3wA:
undetectable		 1ya3B-3c3wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 188
SER A  83
ASP A 105
ASP A 145
 None
 1.29A 2br4B-3c3wA:
2.4		 2br4B-3c3wA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  69
MET A  73
MET A 109
 None
 0.95A 2vavF-3c3wA:
undetectable		 2vavF-3c3wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  50
VAL A  52
LEU A  53
MET A 194
 None
 1.00A 4e1gB-3c3wA:
undetectable		 4e1gB-3c3wA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  60
GLY A  62
LEU A  53
VAL A   7
 None
 0.77A 4fgzA-3c3wA:
undetectable		 4fgzA-3c3wA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		5 / 12 MET A 109
LEU A 147
ILE A  63
LEU A 158
LEU A  70
 None
 1.19A 4j24D-3c3wA:
undetectable		 4j24D-3c3wA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  63
VAL A  55
LEU A 188
LEU A 161
LEU A 158
 None
 0.94A 4o1zA-3c3wA:
undetectable		 4o1zA-3c3wA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  79
ALA A  51
LEU A  76
ILE A 106
LEU A  65
 None
 1.14A 4pxmB-3c3wA:
undetectable		 4pxmB-3c3wA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		4 / 5 GLU A  38
ASP A  59
VAL A   7
ALA A  33
 None
 1.40A 5dl9A-3c3wA:
undetectable		 5dl9A-3c3wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		5 / 10 PRO A  44
ALA A  46
PHE A   5
VAL A   7
PRO A  58
 None
 1.34A 5m0oA-3c3wA:
undetectable		 5m0oA-3c3wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  79
ALA A  51
LEU A  76
ILE A 106
LEU A  65
 None
 1.16A 6cbzB-3c3wA:
undetectable		 6cbzB-3c3wA:
18.23