SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c3y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 8 PHE A 232
PHE A 152
THR A  88
LEU A  66
 None
 1.27A 1ea1A-3c3yA:
undetectable		 1ea1A-3c3yA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.61A 1eizA-3c3yA:
14.4		 1eizA-3c3yA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.65A 1ej0A-3c3yA:
14.4		 1ej0A-3c3yA:
24.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		8 / 12 GLY A  78
PHE A  80
TYR A  83
SER A  84
ALA A 131
ALA A 155
ASP A 156
TYR A 163
 SAH  A 464 (-3.7A)
SAH  A 464 (-4.9A)
None
SAH  A 464 (-2.8A)
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.4A)
None
 0.59A 2avdA-3c3yA:
31.9		 2avdA-3c3yA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		7 / 12 GLY A  78
PHE A  80
TYR A  83
ALA A 131
ASP A 154
ALA A 155
TYR A 163
 SAH  A 464 (-3.7A)
SAH  A 464 (-4.9A)
None
SAH  A 464 (-3.5A)
CA  A 238 ( 2.2A)
SAH  A 464 (-3.7A)
None
 0.57A 2avdB-3c3yA:
32.2		 2avdB-3c3yA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
SER A  84
ASP A 130
ASP A 154
ALA A 155
 SAH  A 464 (-3.7A)
SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
SAH  A 464 (-3.7A)
 0.89A 2br4F-3c3yA:
12.8		 2br4F-3c3yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 11 VAL A  77
GLY A  78
ALA A 131
LEU A 135
ARG A 166
 None
SAH  A 464 (-3.7A)
SAH  A 464 (-3.5A)
None
None
 1.11A 2bxgA-3c3yA:
undetectable		 2bxgA-3c3yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  82
ALA A 100
ASN A  44
PHE A  36
PRO A 113
 SAH  A 464 ( 4.6A)
None
None
None
None
 0.98A 2dpmA-3c3yA:
9.6		 2dpmA-3c3yA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 4 THR A  54
THR A  81
ASP A 102
ASP A 130
 SAH  A 464 (-3.5A)
None
SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
 0.99A 2f8lA-3c3yA:
14.8		 2f8lA-3c3yA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.45A 2igtA-3c3yA:
15.1		 2igtA-3c3yA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.46A 2igtB-3c3yA:
15.2		 2igtB-3c3yA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 6 THR A  54
THR A  81
ASP A 102
ASP A 130
 SAH  A 464 (-3.5A)
None
SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
 0.92A 2okcA-3c3yA:
11.8		 2okcA-3c3yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 6 GLY A  78
SER A  84
ILE A 101
ASP A 154
 SAH  A 464 (-3.7A)
SAH  A 464 (-2.8A)
None
CA  A 238 ( 2.2A)
 0.42A 3a7eA-3c3yA:
22.3		 3a7eA-3c3yA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 ASP A 102
ASP A 130
ASP A 154
 SAH  A 464 (-2.8A)
SAH  A 464 (-4.1A)
CA  A 238 ( 2.2A)
 0.57A 3douA-3c3yA:
13.1		 3douA-3c3yA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 11 GLU A  76
GLY A  78
ILE A 101
ASP A 130
ALA A 131
 SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
SAH  A 464 (-4.1A)
SAH  A 464 (-3.5A)
 0.60A 3dxyA-3c3yA:
13.4		 3dxyA-3c3yA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 VAL A  77
GLY A  78
ASP A 104
ASP A 130
ALA A 131
 None
SAH  A 464 (-3.7A)
None
SAH  A 464 (-4.1A)
SAH  A 464 (-3.5A)
 0.66A 3fuuA-3c3yA:
13.4		 3fuuA-3c3yA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLU A  76
GLY A  78
ASP A 104
ASP A 130
ALA A 131
 SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
SAH  A 464 (-4.1A)
SAH  A 464 (-3.5A)
 0.67A 3gryA-3c3yA:
13.3		 3gryA-3c3yA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
ASP A 102
PHE A 103
ASP A 130
ASP A 180
 SAH  A 464 (-3.7A)
SAH  A 464 (-2.8A)
SAH  A 464 (-3.6A)
SAH  A 464 (-4.1A)
CA  A 238 (-3.3A)
 0.70A 3iv6B-3c3yA:
11.9		 3iv6B-3c3yA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
ILE A 101
ASP A 130
ALA A 131
ASP A 154
 SAH  A 464 (-3.7A)
None
SAH  A 464 (-4.1A)
SAH  A 464 (-3.5A)
CA  A 238 ( 2.2A)
 0.82A 3nvkI-3c3yA:
14.2		 3nvkI-3c3yA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 10 MET A  52
GLU A  76
GLY A  78
SER A  84
ASP A 154
 SAH  A 464 (-3.9A)
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
SAH  A 464 (-2.8A)
CA  A 238 ( 2.2A)
 0.37A 3s68A-3c3yA:
21.7		 3s68A-3c3yA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 10 MET A  52
ASP A 154
LYS A 157
ASP A 180
ASN A 181
 SAH  A 464 (-3.9A)
CA  A 238 ( 2.2A)
CA  A 238 ( 4.0A)
CA  A 238 (-3.3A)
CA  A 238 (-2.9A)
 0.32A 3s68A-3c3yA:
21.8		 3s68A-3c3yA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 PHE A 126
GLY A  82
GLY A 111
ILE A 124
ASP A 102
 None
SAH  A 464 ( 4.6A)
None
None
SAH  A 464 (-2.8A)
 1.08A 4a6dA-3c3yA:
11.3		 4a6dA-3c3yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 PHE A 126
GLY A  82
GLY A 111
ILE A 124
ASP A 102
 None
SAH  A 464 ( 4.6A)
None
None
SAH  A 464 (-2.8A)
 1.01A 4a6eA-3c3yA:
11.1		 4a6eA-3c3yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
ASP A 104
ALA A 131
ALA A 155
TYR A 163
 SAH  A 464 (-3.7A)
None
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
None
 0.84A 4pclA-3c3yA:
28.5		 4pclA-3c3yA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLU A  76
GLY A  78
ALA A 131
ALA A 155
TYR A 163
 SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
None
 0.34A 4pclB-3c3yA:
28.6		 4pclB-3c3yA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 10 MET A  52
ASP A 154
LYS A 157
ASP A 180
ASN A 181
 SAH  A 464 (-3.9A)
CA  A 238 ( 2.2A)
CA  A 238 ( 4.0A)
CA  A 238 (-3.3A)
CA  A 238 (-2.9A)
 0.30A 4pylA-3c3yA:
22.3		 4pylA-3c3yA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 THR A  54
GLY A  78
GLY A  82
ALA A 131
ALA A 155
 SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
SAH  A 464 ( 4.6A)
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
 0.83A 4uciA-3c3yA:
8.2		 4uciA-3c3yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 THR A  54
GLY A  78
GLY A  82
ALA A 131
ALA A 155
 SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
SAH  A 464 ( 4.6A)
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
 0.84A 4uciB-3c3yA:
8.2		 4uciB-3c3yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 THR A  54
GLY A  78
GLY A  82
ALA A 131
ALA A 155
 SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
SAH  A 464 ( 4.6A)
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
 0.80A 4uckA-3c3yA:
8.2		 4uckA-3c3yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 MET A  52
GLU A  76
GLY A  78
TYR A  83
ILE A 101
 SAH  A 464 (-3.9A)
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
None
 0.57A 4xucA-3c3yA:
21.8		 4xucA-3c3yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 MET A  52
GLU A  76
GLY A  78
TYR A  83
ILE A 101
 SAH  A 464 (-3.9A)
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
None
 0.60A 4xudA-3c3yA:
21.6		 4xudA-3c3yA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 5 GLY A  78
TYR A  83
SER A  84
ASP A 154
 SAH  A 464 (-3.7A)
None
SAH  A 464 (-2.8A)
CA  A 238 ( 2.2A)
 0.53A 4xueA-3c3yA:
21.9		 4xueA-3c3yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
TYR A  83
ALA A 131
ALA A 155
TYR A 163
 SAH  A 464 (-3.7A)
None
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
None
 0.53A 4ymgA-3c3yA:
25.9		 4ymgA-3c3yA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		7 / 12 GLY A  78
TYR A  83
SER A  84
ALA A 131
ASP A 154
ALA A 155
TYR A 163
 SAH  A 464 (-3.7A)
None
SAH  A 464 (-2.8A)
SAH  A 464 (-3.5A)
CA  A 238 ( 2.2A)
SAH  A 464 (-3.7A)
None
 0.53A 4ymgB-3c3yA:
24.7		 4ymgB-3c3yA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 11 GLY A 111
PRO A 113
PHE A 126
ASN A  44
VAL A  79
 None
 1.39A 5c8tB-3c3yA:
6.0		 5c8tB-3c3yA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 ASN A 210
ASP A 228
GLY A  13
 None
 0.53A 5fctB-3c3yA:
undetectable		 5fctB-3c3yA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 VAL A  65
LEU A  66
MET A 168
ILE A 176
LEU A 213
 None
 1.19A 5hbsA-3c3yA:
undetectable		 5hbsA-3c3yA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		9 / 12 MET A  52
GLU A  76
GLY A  78
TYR A  83
ALA A 131
ASP A 154
ALA A 155
ASP A 156
TYR A 163
 SAH  A 464 (-3.9A)
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
SAH  A 464 (-3.5A)
CA  A 238 ( 2.2A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.4A)
None
 0.49A 5kvaA-3c3yA:
36.6		 5kvaA-3c3yA:
46.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		6 / 12 THR A  81
GLU A  76
GLY A  78
ALA A 155
ASP A 156
TYR A 163
 None
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.4A)
None
 1.25A 5kvaA-3c3yA:
36.6		 5kvaA-3c3yA:
46.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 THR A  54
SER A  84
ASP A 102
 SAH  A 464 (-3.5A)
SAH  A 464 (-2.8A)
SAH  A 464 (-2.8A)
 0.18A 5kvaA-3c3yA:
36.6		 5kvaA-3c3yA:
46.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		9 / 12 MET A  52
GLU A  76
GLY A  78
TYR A  83
ALA A 131
ASP A 154
ALA A 155
ASP A 156
TYR A 163
 SAH  A 464 (-3.9A)
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
SAH  A 464 (-3.5A)
CA  A 238 ( 2.2A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.4A)
None
 0.58A 5kvaB-3c3yA:
34.7		 5kvaB-3c3yA:
46.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		6 / 12 THR A  81
GLU A  76
GLY A  78
ALA A 155
ASP A 156
TYR A 163
 None
SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.7A)
SAH  A 464 (-3.4A)
None
 1.27A 5kvaB-3c3yA:
34.7		 5kvaB-3c3yA:
46.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 THR A  54
SER A  84
ASP A 102
 SAH  A 464 (-3.5A)
SAH  A 464 (-2.8A)
SAH  A 464 (-2.8A)
 0.16A 5kvaB-3c3yA:
34.7		 5kvaB-3c3yA:
46.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		6 / 6 MET A  52
ASP A 154
LYS A 157
ASP A 180
ASN A 181
TRP A 184
 SAH  A 464 (-3.9A)
CA  A 238 ( 2.2A)
CA  A 238 ( 4.0A)
CA  A 238 (-3.3A)
CA  A 238 (-2.9A)
None
 0.39A 5logA-3c3yA:
32.3		 5logA-3c3yA:
40.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		7 / 12 GLU A  76
GLY A  78
TYR A  83
ALA A 131
PHE A 152
ALA A 155
TYR A 163
 SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
SAH  A 464 (-3.5A)
None
SAH  A 464 (-3.7A)
None
 0.35A 5n5dA-3c3yA:
27.3		 5n5dA-3c3yA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 7 PHE A  80
SER A  84
ILE A 101
ASP A 154
 SAH  A 464 (-4.9A)
SAH  A 464 (-2.8A)
None
CA  A 238 ( 2.2A)
 0.40A 5n5dA-3c3yA:
27.3		 5n5dA-3c3yA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		7 / 12 GLU A  76
TYR A  83
ILE A 101
ALA A 131
PHE A 152
ALA A 155
TYR A 163
 SAH  A 464 ( 4.2A)
None
None
SAH  A 464 (-3.5A)
None
SAH  A 464 (-3.7A)
None
 0.42A 5n5dB-3c3yA:
27.7		 5n5dB-3c3yA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		4 / 7 GLY A  78
PHE A  80
SER A  84
ASP A 154
 SAH  A 464 (-3.7A)
SAH  A 464 (-4.9A)
SAH  A 464 (-2.8A)
CA  A 238 ( 2.2A)
 0.33A 5n5dB-3c3yA:
27.7		 5n5dB-3c3yA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 9 LEU A 224
ILE A 230
GLY A 229
GLY A  13
LEU A  57
 None
 0.96A 5o96A-3c3yA:
undetectable
5o96B-3c3yA:
undetectable		 5o96A-3c3yA:
22.43
5o96B-3c3yA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLU A  76
GLY A  78
TYR A  83
ALA A 131
ALA A 155
 SAH  A 464 ( 4.2A)
SAH  A 464 (-3.7A)
None
SAH  A 464 (-3.5A)
SAH  A 464 (-3.7A)
 0.71A 5zw4A-3c3yA:
27.1		 5zw4A-3c3yA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
ASP A 102
ASP A 104
ASP A 130
ALA A 131
 SAH  A 464 (-3.7A)
SAH  A 464 (-2.8A)
None
SAH  A 464 (-4.1A)
SAH  A 464 (-3.5A)
 0.71A 6bq4A-3c3yA:
13.2		 6bq4A-3c3yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		5 / 12 GLY A  78
ASP A 102
ASP A 104
ASP A 130
ALA A 131
 SAH  A 464 (-3.7A)
SAH  A 464 (-2.8A)
None
SAH  A 464 (-4.1A)
SAH  A 464 (-3.5A)
 0.72A 6bq4B-3c3yA:
13.1		 6bq4B-3c3yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3c3y O-METHYLTRANSFERASE
(Mesembryanthemum
crystallinum) 		3 / 3 THR A  81
GLU A  33
ASN A  44
 None
 0.85A 6nj9K-3c3yA:
11.5		 6nj9K-3c3yA:
19.30