SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_A_NCAA700_0 (EXOTOXIN A)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 7	HIS A 384 GLY A 385 TYR A 414 TYR A 425	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 (-3.5A)	0.37A	1dmaA-3c49A: 5.9	1dmaA-3c49A: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_A_NCAA700_0 (EXOTOXIN A)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 7	HIS A 384 TYR A 414 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-4.1A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.66A	1dmaA-3c49A: 5.9	1dmaA-3c49A: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_B_NCAB700_0 (EXOTOXIN A)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	6 / 6	HIS A 384 GLY A 385 TYR A 414 ALA A 416 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.53A	1dmaB-3c49A: 5.8	1dmaB-3c49A: 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_A_ROFA502_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	3 / 3	ASN A 419 TRP A 383 GLN A 512	None	1.13A	1xoqA-3c49A: undetectable	1xoqA-3c49A: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9Y_A_FUNA500_1 (CARBONIC ANHYDRASE II)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	5 / 12	VAL A 361 PHE A 440 VAL A 391 LEU A 192 THR A 189	None	1.07A	1z9yA-3c49A: undetectable	1z9yA-3c49A: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAT_A_CLMA301_0 (XENOBIOTIC ACETYLTRANSFERASE)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	3 / 3	GLY A 385 TYR A 425 SER A 422	KU8 A 601 (-3.5A) KU8 A 601 (-3.5A) KU8 A 601 (-2.9A)	0.71A	2xatA-3c49A: undetectable	2xatA-3c49A: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IAZ_A_AINA1202_1 (LACTOTRANSFERRIN)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	3 / 3	GLU A 344 GLY A 347 THR A 346	None	0.55A	3iazA-3c49A: undetectable	3iazA-3c49A: 23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9H_A_NCAA1163_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 ALA A 416 LYS A 421 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.97A	3u9hA-3c49A: 18.8	3u9hA-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9H_A_NCAA1163_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 TYR A 425	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A)	0.64A	3u9hA-3c49A: 18.8	3u9hA-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9H_B_NCAB1164_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 ALA A 416 LYS A 421 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.96A	3u9hB-3c49A: 18.8	3u9hB-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9H_B_NCAB1164_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 TYR A 425	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A)	0.67A	3u9hB-3c49A: 18.8	3u9hB-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7A_B_RGZB601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	5 / 12	LEU A 322 LEU A 395 LEU A 528 ILE A 196 TYR A 438	None	1.14A	4a7aB-3c49A: undetectable	4a7aB-3c49A: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AE1_A_NCAA1536_0 (DIPHTHERIA TOXIN)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	5 / 6	HIS A 384 GLY A 385 TYR A 414 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.49A	4ae1A-3c49A: 6.3	4ae1A-3c49A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AE1_B_NCAB1536_0 (DIPHTHERIA TOXIN)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	5 / 5	HIS A 384 GLY A 385 TYR A 414 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.56A	4ae1B-3c49A: 6.2	4ae1B-3c49A: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BJC_A_RPBA2162_1 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 ALA A 416 LYS A 421 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.90A	4bjcA-3c49A: 17.9	4bjcA-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BJC_A_RPBA2162_1 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 TYR A 425	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A)	0.55A	4bjcA-3c49A: 17.9	4bjcA-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BUP_B_SAMB500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	3 / 3	HIS A 434 GLU A 530 ASN A 195	None	0.97A	4bupB-3c49A: undetectable	4bupB-3c49A: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HYF_A_NCAA1201_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 7	HIS A 384 GLY A 385 TYR A 414 ALA A 416 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.71A	4hyfA-3c49A: 19.5	4hyfA-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HYF_B_NCAB1201_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	8 / 8	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.76A	4hyfB-3c49A: 19.6	4hyfB-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HYF_C_NCAC1201_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.9A)	0.99A	4hyfC-3c49A: 19.6	4hyfC-3c49A: 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HYF_C_NCAC1201_0 (TANKYRASE-2)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 8	HIS A 384 GLY A 385 TYR A 414 ALA A 416 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.66A	4hyfC-3c49A: 19.6	4hyfC-3c49A: 23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RV6_A_RPBA1103_1 (POLY [ADP-RIBOSE] POLYMERASE 1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 11	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.9A)	0.96A	4rv6A-3c49A: 41.8	4rv6A-3c49A: 37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RV6_A_RPBA1103_1 (POLY [ADP-RIBOSE] POLYMERASE 1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 11	HIS A 384 GLY A 385 TYR A 414 ALA A 416 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.55A	4rv6A-3c49A: 41.8	4rv6A-3c49A: 37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RV6_B_RPBB1103_1 (POLY [ADP-RIBOSE] POLYMERASE 1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 11	HIS A 384 GLY A 385 TYR A 414 ALA A 416 LYS A 421 SER A 422 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-4.3A) KU8 A 601 (-2.9A) KU8 A 601 (-3.9A)	0.96A	4rv6B-3c49A: 41.9	4rv6B-3c49A: 37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4RV6_B_RPBB1103_1 (POLY [ADP-RIBOSE] POLYMERASE 1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	7 / 11	HIS A 384 GLY A 385 TYR A 414 ALA A 416 SER A 422 TYR A 425 GLU A 514	KU8 A 601 (-4.0A) KU8 A 601 (-3.5A) KU8 A 601 (-4.1A) KU8 A 601 ( 4.0A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A) KU8 A 601 (-3.9A)	0.55A	4rv6B-3c49A: 41.9	4rv6B-3c49A: 37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XOY_A_DX4A401_0 (MITOGEN-ACTIVATED PROTEIN KINASE 1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 6	ALA A 281 GLN A 280 LEU A 278 LEU A 233	None	1.12A	4xoyA-3c49A: undetectable	4xoyA-3c49A: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVC_A_BEZA301_0 (DIGUANYLATE CYCLASE DOSC)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 8	ILE A 339 LEU A 343 LEU A 441 ILE A 358	None	0.63A	4zvcA-3c49A: 3.5 4zvcB-3c49A: 3.3	4zvcA-3c49A: 15.28 4zvcB-3c49A: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVC_A_BEZA301_0 (DIGUANYLATE CYCLASE DOSC)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 8	ILE A 358 ILE A 339 LEU A 343 LEU A 441	None	0.61A	4zvcA-3c49A: 3.5 4zvcB-3c49A: 3.3	4zvcA-3c49A: 15.28 4zvcB-3c49A: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVC_A_BEZA301_0 (DIGUANYLATE CYCLASE DOSC)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 8	ILE A 358 LEU A 355 LEU A 343 LEU A 441	None	0.80A	4zvcA-3c49A: 3.5 4zvcB-3c49A: 3.3	4zvcA-3c49A: 15.28 4zvcB-3c49A: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZVC_A_BEZA301_0 (DIGUANYLATE CYCLASE DOSC)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 8	LEU A 343 LEU A 441 ILE A 358 LEU A 355	None	0.80A	4zvcA-3c49A: 3.5 4zvcB-3c49A: 3.3	4zvcA-3c49A: 15.28 4zvcB-3c49A: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDP_H_EVPH2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 6	GLU A 367 GLY A 447 ASP A 467 GLY A 377	None	0.72A	5cdpA-3c49A: 3.9 5cdpB-3c49A: undetectable	5cdpA-3c49A: 19.80 5cdpB-3c49A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DXE_A_ESTA1000_1 (ESTROGEN RECEPTOR)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 8	MET A 285 LEU A 286 GLU A 234 HIS A 263	None	1.20A	5dxeA-3c49A: undetectable	5dxeA-3c49A: 21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HA9_B_TP0B406_1 (POLY [ADP-RIBOSE] POLYMERASE 1)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	5 / 9	HIS A 384 ILE A 394 TYR A 414 SER A 422 TYR A 425	KU8 A 601 (-4.0A) None KU8 A 601 (-4.1A) KU8 A 601 (-2.9A) KU8 A 601 (-3.5A)	0.48A	5ha9B-3c49A: 40.8	5ha9B-3c49A: 37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_A_SAMA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	3 / 3	HIS A 434 GLU A 530 ASN A 195	None	0.94A	5wbvA-3c49A: undetectable	5wbvA-3c49A: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WBV_B_SAMB402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	3 / 3	HIS A 434 GLU A 530 ASN A 195	None	0.94A	5wbvB-3c49A: undetectable	5wbvB-3c49A: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X80_B_SALB203_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 6	GLY A 385 TYR A 425 LEU A 399 VAL A 390	KU8 A 601 (-3.5A) KU8 A 601 (-3.5A) KU8 A 601 ( 4.5A) None	0.86A	5x80A-3c49A: undetectable 5x80B-3c49A: undetectable	5x80A-3c49A: 20.06 5x80B-3c49A: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CBZ_A_ESTA601_1 (ESTROGEN RECEPTOR)	3c49	POLY(ADP-RIBOSE) POLYMERASE 3 (Homo sapiens)	4 / 8	MET A 285 LEU A 286 GLU A 234 HIS A 263	None	1.20A	6cbzA-3c49A: undetectable	6cbzA-3c49A: 13.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DMA_A_NCAA700_0","EXOTOXIN A","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"HIS A 384;GLY A 385;TYR A 414;TYR A 425","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 (-3.5A)","0.37A","1dmaA-3c49A:5.9","1dmaA-3c49A:18.36"],["1DMA_A_NCAA700_0","EXOTOXIN A","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"HIS A 384;TYR A 414;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-4.1A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.66A","1dmaA-3c49A:5.9","1dmaA-3c49A:18.36"],["1DMA_B_NCAB700_0","EXOTOXIN A","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",6,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.53A","1dmaB-3c49A:5.8","1dmaB-3c49A:18.36"],["1XOQ_A_ROFA502_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",3,"ASN A 419;TRP A 383;GLN A 512","None","1.13A","1xoqA-3c49A:undetectable","1xoqA-3c49A:21.58"],["1Z9Y_A_FUNA500_1","CARBONIC ANHYDRASE II","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",5,"VAL A 361;PHE A 440;VAL A 391;LEU A 192;THR A 189","None","1.07A","1z9yA-3c49A:undetectable","1z9yA-3c49A:18.96"],["2XAT_A_CLMA301_0","XENOBIOTIC ACETYLTRANSFERASE","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",3,"GLY A 385;TYR A 425;SER A 422","KU8 A 601 (-3.5A);KU8 A 601 (-3.5A);KU8 A 601 (-2.9A)","0.71A","2xatA-3c49A:undetectable","2xatA-3c49A:19.89"],["3IAZ_A_AINA1202_1","LACTOTRANSFERRIN","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",3,"GLU A 344;GLY A 347;THR A 346","None","0.55A","3iazA-3c49A:undetectable","3iazA-3c49A:23.35"],["3U9H_A_NCAA1163_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;ALA A 416;LYS A 421;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.97A","3u9hA-3c49A:18.8","3u9hA-3c49A:23.24"],["3U9H_A_NCAA1163_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;TYR A 425","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A)","0.64A","3u9hA-3c49A:18.8","3u9hA-3c49A:23.24"],["3U9H_B_NCAB1164_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;ALA A 416;LYS A 421;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.96A","3u9hB-3c49A:18.8","3u9hB-3c49A:23.24"],["3U9H_B_NCAB1164_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;TYR A 425","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A)","0.67A","3u9hB-3c49A:18.8","3u9hB-3c49A:23.24"],["4A7A_B_RGZB601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",5,"LEU A 322;LEU A 395;LEU A 528;ILE A 196;TYR A 438","None","1.14A","4a7aB-3c49A:undetectable","4a7aB-3c49A:21.40"],["4AE1_A_NCAA1536_0","DIPHTHERIA TOXIN","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",5,"HIS A 384;GLY A 385;TYR A 414;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.49A","4ae1A-3c49A:6.3","4ae1A-3c49A:undetectable"],["4AE1_B_NCAB1536_0","DIPHTHERIA TOXIN","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",5,"HIS A 384;GLY A 385;TYR A 414;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.56A","4ae1B-3c49A:6.2","4ae1B-3c49A:24.34"],["4BJC_A_RPBA2162_1","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;ALA A 416;LYS A 421;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.90A","4bjcA-3c49A:17.9","4bjcA-3c49A:23.24"],["4BJC_A_RPBA2162_1","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;TYR A 425","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A)","0.55A","4bjcA-3c49A:17.9","4bjcA-3c49A:23.24"],["4BUP_B_SAMB500_1","HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",3,"HIS A 434;GLU A 530;ASN A 195","None","0.97A","4bupB-3c49A:undetectable","4bupB-3c49A:20.16"],["4HYF_A_NCAA1201_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.71A","4hyfA-3c49A:19.5","4hyfA-3c49A:23.24"],["4HYF_B_NCAB1201_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",8,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.76A","4hyfB-3c49A:19.6","4hyfB-3c49A:23.24"],["4HYF_C_NCAC1201_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.9A)","0.99A","4hyfC-3c49A:19.6","4hyfC-3c49A:23.24"],["4HYF_C_NCAC1201_0","TANKYRASE-2","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.66A","4hyfC-3c49A:19.6","4hyfC-3c49A:23.24"],["4RV6_A_RPBA1103_1","POLY [ADP-RIBOSE] POLYMERASE 1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.9A)","0.96A","4rv6A-3c49A:41.8","4rv6A-3c49A:37.23"],["4RV6_A_RPBA1103_1","POLY [ADP-RIBOSE] POLYMERASE 1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.55A","4rv6A-3c49A:41.8","4rv6A-3c49A:37.23"],["4RV6_B_RPBB1103_1","POLY [ADP-RIBOSE] POLYMERASE 1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;LYS A 421;SER A 422;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-4.3A);KU8 A 601 (-2.9A);KU8 A 601 (-3.9A)","0.96A","4rv6B-3c49A:41.9","4rv6B-3c49A:37.23"],["4RV6_B_RPBB1103_1","POLY [ADP-RIBOSE] POLYMERASE 1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",7,"HIS A 384;GLY A 385;TYR A 414;ALA A 416;SER A 422;TYR A 425;GLU A 514","KU8 A 601 (-4.0A);KU8 A 601 (-3.5A);KU8 A 601 (-4.1A);KU8 A 601 ( 4.0A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A);KU8 A 601 (-3.9A)","0.55A","4rv6B-3c49A:41.9","4rv6B-3c49A:37.23"],["4XOY_A_DX4A401_0","MITOGEN-ACTIVATED PROTEIN KINASE 1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"ALA A 281;GLN A 280;LEU A 278;LEU A 233","None","1.12A","4xoyA-3c49A:undetectable","4xoyA-3c49A:22.06"],["4ZVC_A_BEZA301_0","DIGUANYLATE CYCLASE DOSC","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"ILE A 339;LEU A 343;LEU A 441;ILE A 358","None","0.63A","4zvcA-3c49A:3.5;4zvcB-3c49A:3.3","4zvcA-3c49A:15.28;4zvcB-3c49A:15.28"],["4ZVC_A_BEZA301_0","DIGUANYLATE CYCLASE DOSC","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"ILE A 358;ILE A 339;LEU A 343;LEU A 441","None","0.61A","4zvcA-3c49A:3.5;4zvcB-3c49A:3.3","4zvcA-3c49A:15.28;4zvcB-3c49A:15.28"],["4ZVC_A_BEZA301_0","DIGUANYLATE CYCLASE DOSC","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"ILE A 358;LEU A 355;LEU A 343;LEU A 441","None","0.80A","4zvcA-3c49A:3.5;4zvcB-3c49A:3.3","4zvcA-3c49A:15.28;4zvcB-3c49A:15.28"],["4ZVC_A_BEZA301_0","DIGUANYLATE CYCLASE DOSC","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"LEU A 343;LEU A 441;ILE A 358;LEU A 355","None","0.80A","4zvcA-3c49A:3.5;4zvcB-3c49A:3.3","4zvcA-3c49A:15.28;4zvcB-3c49A:15.28"],["5CDP_H_EVPH2101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"GLU A 367;GLY A 447;ASP A 467;GLY A 377","None","0.72A","5cdpA-3c49A:3.9;5cdpB-3c49A:undetectable","5cdpA-3c49A:19.80;5cdpB-3c49A:20.17"],["5DXE_A_ESTA1000_1","ESTROGEN RECEPTOR","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"MET A 285;LEU A 286;GLU A 234;HIS A 263","None","1.20A","5dxeA-3c49A:undetectable","5dxeA-3c49A:21.55"],["5HA9_B_TP0B406_1","POLY [ADP-RIBOSE] POLYMERASE 1","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",5,"HIS A 384;ILE A 394;TYR A 414;SER A 422;TYR A 425","KU8 A 601 (-4.0A);None;KU8 A 601 (-4.1A);KU8 A 601 (-2.9A);KU8 A 601 (-3.5A)","0.48A","5ha9B-3c49A:40.8","5ha9B-3c49A:37.06"],["5WBV_A_SAMA402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",3,"HIS A 434;GLU A 530;ASN A 195","None","0.94A","5wbvA-3c49A:undetectable","5wbvA-3c49A:20.71"],["5WBV_B_SAMB402_1","HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",3,"HIS A 434;GLU A 530;ASN A 195","None","0.94A","5wbvB-3c49A:undetectable","5wbvB-3c49A:20.71"],["5X80_B_SALB203_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887;UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"GLY A 385;TYR A 425;LEU A 399;VAL A 390","KU8 A 601 (-3.5A);KU8 A 601 (-3.5A);KU8 A 601 ( 4.5A);None","0.86A","5x80A-3c49A:undetectable;5x80B-3c49A:undetectable","5x80A-3c49A:20.06;5x80B-3c49A:20.06"],["6CBZ_A_ESTA601_1","ESTROGEN RECEPTOR","3c49","POLY(ADP-RIBOSE) POLYMERASE 3","Homo sapiens",4,"MET A 285;LEU A 286;GLU A 234;HIS A 263","None","1.20A","6cbzA-3c49A:undetectable","6cbzA-3c49A:13.17"]]