SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 4 LEU A 356
PRO A 357
LEU A 319
ARG A 321
 None
 1.36A 1hrkB-3c4aA:
undetectable		 1hrkB-3c4aA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		6 / 11 LEU A 292
ALA A  11
ASP A 269
GLY A   7
ILE A  30
VAL A 265
 None
FAD  A 401 (-3.4A)
FAD  A 401 (-2.8A)
FAD  A 401 (-3.6A)
None
None
 1.16A 1hxwB-3c4aA:
undetectable		 1hxwB-3c4aA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 7 CYH A 205
SER A 206
PHE A 187
LEU A 240
 None
 1.09A 1qcaA-3c4aA:
undetectable		 1qcaA-3c4aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 4 LEU A 356
PRO A 357
LEU A 319
ARG A 321
 None
 1.33A 2hrcB-3c4aA:
undetectable		 2hrcB-3c4aA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 4 LEU A 356
PRO A 357
LEU A 319
ARG A 321
 None
 1.40A 2pnjB-3c4aA:
undetectable		 2pnjB-3c4aA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A  42
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 1.02A 2xdcA-3c4aA:
undetectable
2xdcB-3c4aA:
undetectable		 2xdcA-3c4aA:
4.76
2xdcB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A 165
TRP A  42
 None
FAD  A 401 (-4.0A)
None
 1.23A 2xdcA-3c4aA:
undetectable
2xdcB-3c4aA:
undetectable		 2xdcA-3c4aA:
4.76
2xdcB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 TRP A  42
VAL A 203
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 1.22A 2xdcA-3c4aA:
undetectable
2xdcB-3c4aA:
undetectable		 2xdcA-3c4aA:
4.76
2xdcB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 TRP A 165
VAL A 203
TRP A  42
 FAD  A 401 (-4.0A)
None
None
 0.99A 2xdcA-3c4aA:
undetectable
2xdcB-3c4aA:
undetectable		 2xdcA-3c4aA:
4.76
2xdcB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A  42
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 0.90A 2xdcC-3c4aA:
undetectable
2xdcD-3c4aA:
undetectable		 2xdcC-3c4aA:
4.76
2xdcD-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A  42
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 1.00A 2y5mA-3c4aA:
undetectable
2y5mB-3c4aA:
undetectable		 2y5mA-3c4aA:
4.76
2y5mB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A 165
TRP A  42
 None
FAD  A 401 (-4.0A)
None
 1.24A 2y5mA-3c4aA:
undetectable
2y5mB-3c4aA:
undetectable		 2y5mA-3c4aA:
4.76
2y5mB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A  42
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 1.00A 2y6nA-3c4aA:
undetectable
2y6nB-3c4aA:
undetectable		 2y6nA-3c4aA:
4.76
2y6nB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A 165
TRP A  42
 None
FAD  A 401 (-4.0A)
None
 1.24A 2y6nA-3c4aA:
undetectable
2y6nB-3c4aA:
undetectable		 2y6nA-3c4aA:
4.76
2y6nB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 TRP A  42
VAL A 203
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 1.22A 2y6nA-3c4aA:
undetectable
2y6nB-3c4aA:
undetectable		 2y6nA-3c4aA:
4.76
2y6nB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 TRP A 165
VAL A 203
TRP A  42
 FAD  A 401 (-4.0A)
None
None
 1.01A 2y6nA-3c4aA:
undetectable
2y6nB-3c4aA:
undetectable		 2y6nA-3c4aA:
4.76
2y6nB-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 7 GLY A   9
ALA A 285
VAL A 136
ILE A  30
 FAD  A 401 (-3.4A)
FAD  A 401 ( 4.5A)
None
None
 0.79A 3a2qA-3c4aA:
undetectable		 3a2qA-3c4aA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 GLY A   9
GLU A  32
ASN A 139
ALA A 138
LEU A 100
 FAD  A 401 (-3.4A)
FAD  A 401 (-2.5A)
FAD  A 401 (-4.4A)
None
None
 1.17A 3ckkA-3c4aA:
2.4		 3ckkA-3c4aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 THR A 282
THR A 283
LEU A  58
HIS A  53
LEU A 363
 FAD  A 401 (-3.7A)
None
None
None
None
 1.27A 3gwxA-3c4aA:
undetectable		 3gwxA-3c4aA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		6 / 12 LEU A 292
ALA A  11
ASP A 269
GLY A   7
ILE A  30
VAL A 265
 None
FAD  A 401 (-3.4A)
FAD  A 401 (-2.8A)
FAD  A 401 (-3.6A)
None
None
 1.33A 3jw2B-3c4aA:
undetectable		 3jw2B-3c4aA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 7 LEU A 177
ARG A 180
ILE A 188
PHE A 179
 None
 0.73A 3ln1B-3c4aA:
undetectable		 3ln1B-3c4aA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 LEU A  77
PHE A 345
ILE A 188
ILE A 278
ALA A 324
 None
 1.11A 3nxuB-3c4aA:
undetectable		 3nxuB-3c4aA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 VAL A  95
THR A 282
THR A 283
LEU A 104
HIS A  53
 None
FAD  A 401 (-3.7A)
None
None
None
 1.14A 3sp9B-3c4aA:
undetectable		 3sp9B-3c4aA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 7 VAL A  45
GLY A 279
ILE A 278
VAL A  90
 FAD  A 401 (-4.3A)
FAD  A 401 ( 4.0A)
None
None
 0.78A 3ufnB-3c4aA:
undetectable		 3ufnB-3c4aA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 HIS A 102
GLY A  99
ALA A  11
GLY A  12
GLN A 290
 None
None
FAD  A 401 (-3.4A)
None
None
 0.88A 3v3oA-3c4aA:
26.7		 3v3oA-3c4aA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 VAL A 203
TRP A  42
TRP A 165
 None
None
FAD  A 401 (-4.0A)
 0.82A 3zq8A-3c4aA:
undetectable
3zq8B-3c4aA:
undetectable		 3zq8A-3c4aA:
4.76
3zq8B-3c4aA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 5 THR A 181
ILE A 186
GLU A 335
PHE A 345
 None
 1.28A 4ac9C-3c4aA:
undetectable		 4ac9C-3c4aA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 7 ASP A 196
LEU A 171
GLN A 174
LEU A  72
 None
 1.10A 4ib4A-3c4aA:
undetectable		 4ib4A-3c4aA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		6 / 12 LEU A 292
ALA A  11
ASP A 269
GLY A   7
ILE A  30
VAL A 265
 None
FAD  A 401 (-3.4A)
FAD  A 401 (-2.8A)
FAD  A 401 (-3.6A)
None
None
 1.32A 4jecA-3c4aA:
undetectable		 4jecA-3c4aA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 7 ASN A  34
GLU A 118
GLU A  36
GLU A  38
 FAD  A 401 (-3.6A)
None
None
None
 1.22A 4r87I-3c4aA:
undetectable		 4r87I-3c4aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 VAL A 141
GLY A 274
ILE A 278
SER A 327
HIS A 275
 None
 1.34A 4xudA-3c4aA:
2.9		 4xudA-3c4aA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 ALA A 138
GLY A 140
LEU A 271
LEU A 292
GLY A  12
 None
FAD  A 401 (-3.4A)
None
None
None
 1.19A 5jglB-3c4aA:
2.6		 5jglB-3c4aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 ARG A 180
ILE A 188
PHE A 179
 None
 0.57A 5kirA-3c4aA:
undetectable		 5kirA-3c4aA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		5 / 12 GLY A  12
GLY A   9
VAL A 136
VAL A 286
ALA A 285
 None
FAD  A 401 (-3.4A)
None
None
FAD  A 401 ( 4.5A)
 0.89A 5kpcA-3c4aA:
undetectable		 5kpcA-3c4aA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		6 / 9 LEU A 292
ALA A  11
ASP A 269
GLY A   7
ILE A  30
VAL A 265
 None
FAD  A 401 (-3.4A)
FAD  A 401 (-2.8A)
FAD  A 401 (-3.6A)
None
None
 1.26A 5kr0B-3c4aA:
undetectable		 5kr0B-3c4aA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		4 / 5 TYR A  60
VAL A 286
PRO A  10
ALA A 289
 None
None
FAD  A 401 (-3.4A)
None
 1.14A 5otrA-3c4aA:
undetectable		 5otrA-3c4aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD
(Chromobacterium
violaceum) 		3 / 3 GLY A 125
LEU A 127
HIS A 124
 None
 0.67A 5u63B-3c4aA:
8.5		 5u63B-3c4aA:
23.48