SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		5 / 11 ALA A1733
ILE A1795
LEU A1667
ILE A1657
TYR A1818
 None
 1.05A 1dg5A-3c4bA:
undetectable		 1dg5A-3c4bA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		5 / 12 ALA A1733
ILE A1795
LEU A1667
ILE A1657
TYR A1818
 None
 1.08A 2w3vA-3c4bA:
undetectable		 2w3vA-3c4bA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		5 / 12 ALA A1733
ILE A1795
LEU A1667
ILE A1657
TYR A1818
 None
 1.19A 3qfxB-3c4bA:
undetectable		 3qfxB-3c4bA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		5 / 11 TYR A1741
PHE A1653
ILE A1795
ILE A1753
MET A1821
 None
 1.09A 4dz2A-3c4bA:
undetectable
4dz2B-3c4bA:
undetectable		 4dz2A-3c4bA:
16.73
4dz2B-3c4bA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		5 / 11 MET A1821
TYR A1741
PHE A1653
ILE A1795
ILE A1753
 None
 1.10A 4dz2A-3c4bA:
undetectable
4dz2B-3c4bA:
undetectable		 4dz2A-3c4bA:
16.73
4dz2B-3c4bA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		4 / 6 ASP A1794
ASN A1726
ASP A1693
GLU A1689
 None
 1.25A 4gkhJ-3c4bA:
undetectable		 4gkhJ-3c4bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3c4b ENDORIBONUCLEASE
DICER
(Mus
musculus) 		5 / 12 ALA A1733
ILE A1795
LEU A1667
ILE A1657
TYR A1818
 None
 1.08A 4m2xG-3c4bA:
undetectable		 4m2xG-3c4bA:
20.75