SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		5 / 11 VAL A 163
LEU A  95
LEU A  36
LEU A  41
HIS A 177
 None
 1.27A 1mmtA-3c5cA:
undetectable		 1mmtA-3c5cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		5 / 12 LEU A 132
VAL A 175
PHE A 176
ALA A 183
ALA A 179
 None
 1.28A 1q23A-3c5cA:
undetectable
1q23B-3c5cA:
undetectable		 1q23A-3c5cA:
21.19
1q23B-3c5cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		5 / 12 LEU A 132
VAL A 175
PHE A 176
VAL A 180
ALA A 179
 None
 1.22A 1q23H-3c5cA:
undetectable
1q23I-3c5cA:
undetectable		 1q23H-3c5cA:
21.19
1q23I-3c5cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		5 / 11 ALA A  76
ASN A 134
GLY A  32
THR A  37
VAL A  72
 None
GDP  A 201 (-3.3A)
GDP  A 201 (-3.2A)
None
None
 1.21A 3rukD-3c5cA:
undetectable		 3rukD-3c5cA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		5 / 12 VAL A 144
PHE A 106
PHE A 156
LEU A 131
VAL A  96
 None
 1.02A 4eckA-3c5cA:
undetectable		 4eckA-3c5cA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3c5c RAS-LIKE PROTEIN 12
(Homo
sapiens) 		4 / 8 ALA A 129
ILE A  25
ALA A  24
LEU A  23
 None
 0.80A 5te8B-3c5cA:
undetectable		 5te8B-3c5cA:
16.46