SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		3 / 3 VAL A  94
VAL A  19
TRP A  76
 None
 0.94A 1bdwA-3c5hA:
undetectable
1bdwB-3c5hA:
undetectable		 1bdwA-3c5hA:
3.90
1bdwB-3c5hA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 7 TYR A 185
SER A 182
ILE A 164
SER A 219
 None
 0.85A 2xz5A-3c5hA:
undetectable
2xz5B-3c5hA:
undetectable		 2xz5A-3c5hA:
23.13
2xz5B-3c5hA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 8 TYR A 185
SER A 182
ILE A 164
SER A 219
 None
 0.86A 2xz5B-3c5hA:
undetectable
2xz5E-3c5hA:
undetectable		 2xz5B-3c5hA:
23.13
2xz5E-3c5hA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 11 VAL A 236
LEU A 161
VAL A  18
SER A 241
ILE A  16
 None
 1.23A 2zbzA-3c5hA:
undetectable		 2zbzA-3c5hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 3jwxA-3c5hA:
0.0
3jwxB-3c5hA:
0.2		 3jwxA-3c5hA:
18.76
3jwxB-3c5hA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 3jwyA-3c5hA:
0.0
3jwyB-3c5hA:
0.0		 3jwyA-3c5hA:
18.76
3jwyB-3c5hA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.46A 3n5sA-3c5hA:
undetectable
3n5sB-3c5hA:
undetectable		 3n5sA-3c5hA:
18.76
3n5sB-3c5hA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 3n6fA-3c5hA:
undetectable
3n6fB-3c5hA:
undetectable		 3n6fA-3c5hA:
17.94
3n6fB-3c5hA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.48A 3n6gA-3c5hA:
0.4
3n6gB-3c5hA:
undetectable		 3n6gA-3c5hA:
17.94
3n6gB-3c5hA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.50A 3nlgA-3c5hA:
0.4
3nlgB-3c5hA:
undetectable		 3nlgA-3c5hA:
18.76
3nlgB-3c5hA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.48A 3nlhA-3c5hA:
0.0
3nlhB-3c5hA:
undetectable		 3nlhA-3c5hA:
17.94
3nlhB-3c5hA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4carA-3c5hA:
0.0
4carB-3c5hA:
0.4		 4carA-3c5hA:
18.81
4carB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4ctyA-3c5hA:
0.0
4ctyB-3c5hA:
0.0		 4ctyA-3c5hA:
18.81
4ctyB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.47A 4ctzA-3c5hA:
0.5
4ctzB-3c5hA:
0.0		 4ctzA-3c5hA:
18.81
4ctzB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4cu0A-3c5hA:
undetectable
4cu0B-3c5hA:
undetectable		 4cu0A-3c5hA:
18.81
4cu0B-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4d39A-3c5hA:
undetectable
4d39B-3c5hA:
undetectable		 4d39A-3c5hA:
18.81
4d39B-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 5 LEU A 243
ILE A  93
ALA A 239
MET A  91
 None
 1.07A 4dc3B-3c5hA:
undetectable		 4dc3B-3c5hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.23A 4djeA-3c5hA:
undetectable		 4djeA-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.06A 4djeB-3c5hA:
undetectable		 4djeB-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.14A 4djfA-3c5hA:
2.1		 4djfA-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.50A 4jslA-3c5hA:
0.0
4jslB-3c5hA:
0.0		 4jslA-3c5hA:
18.81
4jslB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4k5hA-3c5hA:
undetectable
4k5hB-3c5hA:
undetectable		 4k5hA-3c5hA:
18.81
4k5hB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4k5jA-3c5hA:
undetectable
4k5jB-3c5hA:
undetectable		 4k5jA-3c5hA:
18.81
4k5jB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 PHE A 216
ILE A 164
THR A 191
LEU A 162
LEU A 223
 None
 1.31A 4qynB-3c5hA:
undetectable		 4qynB-3c5hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 PHE A 216
ILE A 164
THR A 191
LEU A 162
LEU A 223
 None
 1.33A 4qztC-3c5hA:
undetectable		 4qztC-3c5hA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 6 VAL A  67
ARG A  44
PHE A 134
GLU A 142
 None
UNX  A 305 (-4.1A)
None
None
 1.49A 4uprA-3c5hA:
undetectable
4uprB-3c5hA:
undetectable		 4uprA-3c5hA:
18.81
4uprB-3c5hA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 178
VAL A 181
LEU A  38
ILE A  33
VAL A 226
 None
None
None
GNP  A 301 (-4.3A)
None
 1.14A 4y0pA-3c5hA:
undetectable		 4y0pA-3c5hA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		4 / 8 LEU A 243
ASP A 158
ASN A  15
VAL A  94
 None
 0.75A 4zbqA-3c5hA:
undetectable		 4zbqA-3c5hA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		3 / 3 TYR A 116
TYR A 133
SER A  36
 None
None
MG  A 302 ( 2.1A)
 0.94A 5iktB-3c5hA:
undetectable		 5iktB-3c5hA:
18.68