SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 448
LEU A 469
MET A 375
ILE A 406
 None
 1.18A 1tuvA-3c5nA:
undetectable		 1tuvA-3c5nA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A 297
ALA A 476
PHE A 475
LEU A 273
GLY A 454
 None
 1.31A 1uhoA-3c5nA:
undetectable		 1uhoA-3c5nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 4 GLN A 348
GLU A 349
ILE A 384
PRO A 383
 None
 1.30A 2fcnA-3c5nA:
undetectable		 2fcnA-3c5nA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 458
SER A 434
VAL A 435
 I3P  A   2 ( 4.7A)
I3P  A   2 (-2.5A)
I3P  A   2 ( 3.4A)
 0.62A 3eeoA-3c5nA:
undetectable		 3eeoA-3c5nA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 329
GLY A 315
GLN A 336
ASN A 331
GLY A 332
 None
 1.39A 3kmoA-3c5nA:
undetectable		 3kmoA-3c5nA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 287
LYS A 267
LYS A 290
 None
 1.31A 4k50E-3c5nA:
undetectable		 4k50E-3c5nA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 287
LYS A 267
LYS A 290
 None
 1.40A 4k50I-3c5nA:
undetectable		 4k50I-3c5nA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ILE A 372
PRO A 373
ILE A 406
 None
 0.46A 5hw8F-3c5nA:
undetectable		 5hw8F-3c5nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 PRO A 383
LEU A 243
ILE A 314
VAL A 328
PRO A 373
 None
 1.38A 5m0oA-3c5nA:
undetectable		 5m0oA-3c5nA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 480
TYR A 355
LEU A 469
ALA A 478
LEU A 463
 None
 1.10A 5zwrB-3c5nA:
undetectable		 5zwrB-3c5nA:
21.46