SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 5 HIS P 349
LEU P 305
LEU P 112
GLY P 159
 None
 0.95A 1a4lB-3c5wP:
2.1		 1a4lB-3c5wP:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 5 HIS P 352
LEU P 112
LEU P 177
GLY P 158
 None
 1.13A 1a4lB-3c5wP:
2.1		 1a4lB-3c5wP:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 8 MET P 157
GLU P 129
HIS P 115
LEU P 112
 None
 0.95A 1ereE-3c5wP:
undetectable		 1ereE-3c5wP:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 8 MET P 157
GLU P 129
HIS P 115
LEU P 112
 None
 0.96A 1ereF-3c5wP:
undetectable		 1ereF-3c5wP:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 12 HIS P 115
GLY P 116
VAL P  58
ASP P  65
VAL P 120
 None
 1.26A 1n2xA-3c5wP:
3.5		 1n2xA-3c5wP:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		3 / 3 ASP P 354
ARG P 222
ASP P 181
 None
 0.73A 1vptA-3c5wP:
2.9		 1vptA-3c5wP:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 8 LEU A  35
ILE A 408
ARG A  28
ILE A  32
ILE A 423
 None
 1.22A 2bu8A-3c5wA:
undetectable		 2bu8A-3c5wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A  29
ASN A  30
GLU A  19
LEU A  16
 None
 1.13A 2w8yA-3c5wA:
undetectable		 2w8yA-3c5wA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		4 / 5 TYR A 426
ILE A 408
LEU A 446
LEU A 443
 None
 1.09A 2zb7A-3c5wA:
undetectable		 2zb7A-3c5wA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 LEU P  90
ILE P 107
LYS P  71
SER P  72
SER P  52
 None
 1.24A 3bjwB-3c5wP:
undetectable		 3bjwB-3c5wP:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 LEU P  90
ILE P 107
LYS P  71
SER P  72
SER P  52
 None
 1.21A 3bjwH-3c5wP:
undetectable		 3bjwH-3c5wP:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.83A 3ebzB-3c5wA:
undetectable		 3ebzB-3c5wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 535
ASP A 570
GLN A 571
 None
 0.66A 3eeyC-3c5wA:
undetectable		 3eeyC-3c5wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 535
ASP A 570
GLN A 571
 None
 0.66A 3eeyD-3c5wA:
undetectable		 3eeyD-3c5wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		3 / 3 ASN A 535
ASP A 570
GLN A 571
 None
 0.67A 3eeyE-3c5wA:
undetectable		 3eeyE-3c5wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 12 HIS P 164
GLY P 158
GLY P 159
ALA P 128
TRP P 298
 None
 1.21A 3i5uA-3c5wP:
undetectable		 3i5uA-3c5wP:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 7 GLU P 361
VAL P 363
ALA P  98
ARG P 102
 None
 1.05A 3kp6B-3c5wP:
undetectable		 3kp6B-3c5wP:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 10 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.89A 3ogpA-3c5wA:
undetectable		 3ogpA-3c5wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 10 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.98A 3ogqA-3c5wA:
undetectable		 3ogqA-3c5wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.88A 3ogqB-3c5wA:
undetectable		 3ogqB-3c5wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.79A 3s45B-3c5wA:
undetectable		 3s45B-3c5wA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 567
ALA A 582
GLY A 548
ILE A 547
 None
 0.75A 3spkB-3c5wA:
undetectable		 3spkB-3c5wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 6 LEU P 110
LEU P  80
ILE P 150
THR P 165
 None
 0.92A 4do3B-3c5wP:
undetectable		 4do3B-3c5wP:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		3 / 3 ASP P 354
ARG P 222
ASP P 181
 None
 0.88A 4fp9D-3c5wP:
undetectable		 4fp9D-3c5wP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		3 / 3 ASP P 354
ARG P 222
ASP P 181
 None
 0.71A 4fzvA-3c5wP:
undetectable		 4fzvA-3c5wP:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 5 VAL P 235
ARG P 288
MET P 231
LEU P 208
 None
 1.42A 4hojA-3c5wP:
undetectable		 4hojA-3c5wP:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 434
LEU A 443
LEU A  20
LEU A 400
LEU A  16
 None
 1.06A 4zowA-3c5wA:
undetectable		 4zowA-3c5wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 10 MET P 341
LEU P 318
LEU P 320
GLY P 159
MET P 179
 None
 1.35A 4zp0A-3c5wP:
0.0		 4zp0A-3c5wP:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 12 ILE P 150
VAL P 138
VAL P 135
THR P 165
MET P 142
 None
 1.25A 5bykA-3c5wP:
1.8		 5bykA-3c5wP:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.79A 5e5jA-3c5wA:
undetectable		 5e5jA-3c5wA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 12 SER P  88
LEU P  90
GLU P 353
GLY P 233
VAL P 235
 None
 1.44A 5jo9A-3c5wP:
4.7		 5jo9A-3c5wP:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
 None
 0.87A 5lf3K-3c5wP:
undetectable
5lf3L-3c5wP:
undetectable		 5lf3K-3c5wP:
23.70
5lf3L-3c5wP:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
 None
 0.88A 5lf3Y-3c5wP:
undetectable
5lf3Z-3c5wP:
undetectable		 5lf3Y-3c5wP:
23.70
5lf3Z-3c5wP:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
 None
 0.90A 5lf7K-3c5wP:
undetectable
5lf7L-3c5wP:
undetectable		 5lf7K-3c5wP:
23.70
5lf7L-3c5wP:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
 None
 0.91A 5lf7Y-3c5wP:
undetectable
5lf7Z-3c5wP:
undetectable		 5lf7Y-3c5wP:
23.70
5lf7Z-3c5wP:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		4 / 4 GLN A 514
THR A 518
LEU A 586
LEU A 556
 None
 1.31A 5m5kB-3c5wA:
undetectable		 5m5kB-3c5wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		4 / 4 LEU A 411
MET A 427
ILE A  17
LEU A 405
 None
 1.28A 5nfpA-3c5wA:
undetectable		 5nfpA-3c5wA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		6 / 10 LEU P  81
HIS P  83
ILE P 153
GLY P 154
GLY P 158
VAL P 135
 None
 1.08A 5o96C-3c5wP:
undetectable
5o96D-3c5wP:
undetectable		 5o96C-3c5wP:
22.68
5o96D-3c5wP:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 5 PRO P 147
GLY P 144
TYR P 143
VAL P 171
 None
 1.36A 5x80C-3c5wP:
undetectable
5x80D-3c5wP:
undetectable		 5x80C-3c5wP:
20.20
5x80D-3c5wP:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		3 / 3 ASP P 354
ARG P 222
ASP P 181
 None
 0.83A 5zvgA-3c5wP:
2.1		 5zvgA-3c5wP:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		3 / 3 ASP P 354
ARG P 222
ASP P 181
 None
 0.87A 5zvgB-3c5wP:
undetectable		 5zvgB-3c5wP:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		4 / 8 MET P 157
GLU P 129
HIS P 115
LEU P 112
 None
 0.94A 6cbzA-3c5wP:
undetectable		 6cbzA-3c5wP:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 567
ALA A 582
GLY A 548
ILE A 547
ILE A 563
 None
 0.77A 6dh3A-3c5wA:
undetectable		 6dh3A-3c5wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 11 ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
 None
 1.37A 6dlzA-3c5wA:
undetectable
6dlzD-3c5wA:
undetectable		 6dlzA-3c5wA:
17.39
6dlzD-3c5wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3c5w PP2A A SUBUNIT
(Homo
sapiens) 		5 / 11 ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
 None
 1.37A 6dm1A-3c5wA:
undetectable
6dm1D-3c5wA:
undetectable		 6dm1A-3c5wA:
17.39
6dm1D-3c5wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
 None
 0.92A 6hwdK-3c5wP:
undetectable
6hwdL-3c5wP:
undetectable		 6hwdK-3c5wP:
15.49
6hwdL-3c5wP:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens) 		5 / 11 THR P 165
ALA P 166
GLY P 158
GLY P 159
ALA P 160
 None
 0.92A 6hwdY-3c5wP:
undetectable
6hwdZ-3c5wP:
undetectable		 6hwdY-3c5wP:
15.49
6hwdZ-3c5wP:
13.90