SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A  59
LEU A  60
HIS A  19
TYR A  36
ILE A   6
 None
 1.00A 1fmlA-3c5yA:
2.2		 1fmlA-3c5yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A   3
LEU A  59
LEU A  60
LEU A   5
ILE A   6
 None
 1.23A 1fmlB-3c5yA:
undetectable		 1fmlB-3c5yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A  59
LEU A  60
HIS A  19
TYR A  36
ILE A   6
 None
 1.01A 1fmlB-3c5yA:
undetectable		 1fmlB-3c5yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 7 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.90A 1v55A-3c5yA:
undetectable
1v55J-3c5yA:
undetectable		 1v55A-3c5yA:
17.70
1v55J-3c5yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 LEU A 180
LEU A  55
MET A  85
 None
 0.75A 1ya3B-3c5yA:
undetectable		 1ya3B-3c5yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 ASP A 168
ASP A 163
ASP A 200
GLY A  87
 EDO  A 216 (-2.8A)
EDO  A 214 (-4.3A)
None
None
 1.45A 2igtC-3c5yA:
undetectable		 2igtC-3c5yA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 11 LEU A  55
LEU A  54
LEU A 207
GLY A  63
LEU A  60
 None
None
None
EDO  A 218 ( 3.8A)
None
 1.33A 3hm1B-3c5yA:
undetectable		 3hm1B-3c5yA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A  22
GLY A  37
GLY A 187
HIS A  19
GLY A  71
 None
 1.12A 4blvA-3c5yA:
undetectable		 4blvA-3c5yA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 5 LEU A  22
ILE A 111
MET A 113
PHE A  67
 None
 0.96A 4dc3B-3c5yA:
undetectable		 4dc3B-3c5yA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 8 ILE A   3
ALA A  21
VAL A  25
VAL A  69
 None
 0.60A 5ecnD-3c5yA:
undetectable		 5ecnD-3c5yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLU A   8
GLY A  77
LEU A 127
SER A  10
ILE A   7
 None
 1.19A 5vooA-3c5yA:
undetectable		 5vooA-3c5yA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLU A   8
GLY A  77
LEU A 127
SER A  10
ILE A   7
 None
 1.17A 5vooB-3c5yA:
undetectable		 5vooB-3c5yA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLU A   8
GLY A  77
LEU A 127
SER A  10
ILE A   7
 None
 1.20A 5vooC-3c5yA:
undetectable		 5vooC-3c5yA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLU A   8
GLY A  77
LEU A 127
SER A  10
ILE A   7
 None
 1.17A 5vooE-3c5yA:
undetectable		 5vooE-3c5yA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLU A   8
GLY A  77
LEU A 127
SER A  10
ILE A   7
 None
 1.17A 5vooF-3c5yA:
undetectable		 5vooF-3c5yA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  57
ASN A 109
MET A  85
PHE A  67
THR A  70
 None
 1.47A 5yf0A-3c5yA:
undetectable		 5yf0A-3c5yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A   3
HIS A  31
LEU A 127
ALA A  21
TYR A 115
 None
 1.17A 6djzA-3c5yA:
undetectable		 6djzA-3c5yA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3c5y RIBOSE/GALACTOSE
ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 5 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.82A 6nmpN-3c5yA:
undetectable
6nmpW-3c5yA:
undetectable		 6nmpN-3c5yA:
17.70
6nmpW-3c5yA:
16.34