SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		5 / 10 HIS A  47
ALA A  43
ASN A 263
ALA A  38
ILE A  79
 NI  A 298 (-3.4A)
None
None
None
None
 0.96A 1likA-3c6cA:
undetectable		 1likA-3c6cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		3 / 3 GLU A 250
HIS A  47
HIS A  49
 NI  A 298 (-2.6A)
NI  A 298 (-3.4A)
NI  A 298 (-3.5A)
 0.65A 1oe2A-3c6cA:
undetectable		 1oe2A-3c6cA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		4 / 5 TYR A 254
VAL A 135
ILE A 227
MET A  24
 None
None
PEG  A 303 ( 4.7A)
None
 1.50A 1opjA-3c6cA:
undetectable		 1opjA-3c6cA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		5 / 12 ILE A 124
HIS A  49
HIS A  47
ASP A 128
GLY A  86
 None
NI  A 298 (-3.5A)
NI  A 298 (-3.4A)
None
None
 1.00A 1zz1B-3c6cA:
undetectable
1zz1C-3c6cA:
undetectable		 1zz1B-3c6cA:
22.59
1zz1C-3c6cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_B_CHDB1_0
(FERROCHELATASE)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		5 / 10 LEU A 266
ARG A 246
PRO A  25
SER A  23
GLY A  13
 None
NI  A 298 ( 4.1A)
None
EDO  A 302 (-2.6A)
None
 1.40A 2qd2B-3c6cA:
0.0		 2qd2B-3c6cA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		3 / 3 PHE A  65
CYH A 120
HIS A 116
 None
 1.24A 3u9fG-3c6cA:
undetectable		 3u9fG-3c6cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		4 / 7 GLU A 165
ILE A 124
LYS A 163
VAL A  80
 None
 1.16A 4tvtA-3c6cA:
undetectable		 4tvtA-3c6cA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		3 / 3 LEU A 180
PHE A 192
ILE A 181
 None
 0.68A 5dzk1-3c6cA:
undetectable
5dzkF-3c6cA:
4.3
5dzkM-3c6cA:
undetectable		 5dzk1-3c6cA:
1.80
5dzkF-3c6cA:
20.19
5dzkM-3c6cA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		5 / 10 ARG A 246
VAL A 245
LEU A   7
LEU A 277
GLY A 226
 NI  A 298 ( 4.1A)
None
None
None
None
 1.16A 6eu9B-3c6cA:
undetectable		 6eu9B-3c6cA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME
(Cupriavidus
pinatubonensis) 		4 / 7 VAL A 189
ILE A 124
GLY A 226
ALA A 223
 None
 0.89A 6hd6B-3c6cA:
undetectable		 6hd6B-3c6cA:
13.18