SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 SER A 188
ILE A 211
LEU A 257
GLY A 305
VAL A 253
ALA A 250
 None
None
None
VD3  A 701 ( 3.9A)
VD3  A 701 ( 4.2A)
VD3  A 701 (-3.3A)
 1.40A 1tlsA-3c6gA:
undetectable		 1tlsA-3c6gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 SER A 188
ILE A 211
LEU A 257
GLY A 305
VAL A 253
ALA A 250
 None
None
None
VD3  A 701 ( 3.9A)
VD3  A 701 ( 4.2A)
VD3  A 701 (-3.3A)
 1.47A 1tlsB-3c6gA:
undetectable		 1tlsB-3c6gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 SER A 188
ILE A 211
LEU A 257
GLY A 305
VAL A 253
ALA A 250
 None
None
None
VD3  A 701 ( 3.9A)
VD3  A 701 ( 4.2A)
VD3  A 701 (-3.3A)
 1.39A 1tsnA-3c6gA:
undetectable		 1tsnA-3c6gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 ILE A 401
LEU A  61
LEU A  55
PRO A 376
SER A 442
 None
None
None
None
HEM  A 601 (-2.8A)
 1.16A 1zq9A-3c6gA:
undetectable		 1zq9A-3c6gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A 221
LEU A 485
LEU A 377
THR A 399
 None
VD3  A 701 ( 3.8A)
None
None
None
 1.29A 2oaxB-3c6gA:
undetectable		 2oaxB-3c6gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A 221
LEU A 485
LEU A 377
THR A 399
 None
VD3  A 701 ( 3.8A)
None
None
None
 1.22A 2oaxC-3c6gA:
undetectable		 2oaxC-3c6gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 5 ILE A  52
LEU A  81
ALA A 224
PHE A 380
 None
None
UNX  A   2 ( 3.7A)
None
 0.95A 2opxA-3c6gA:
undetectable		 2opxA-3c6gA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 7 LEU A 466
ALA A 322
LEU A 319
PHE A 165
 None
 0.99A 2vcvG-3c6gA:
undetectable		 2vcvG-3c6gA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 PHE A 196
ASN A 192
PHE A 207
 None
 0.91A 2zbuD-3c6gA:
undetectable		 2zbuD-3c6gA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 ALA A 222
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 1.32A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		7 / 12 THR A 119
ASN A 126
PHE A 214
ALA A 250
VAL A 253
THR A 488
ILE A 379
 None
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.2A)
VD3  A 701 ( 4.6A)
HEM  A 601 ( 4.1A)
 1.48A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		12 / 12 THR A 119
ASN A 126
PHE A 214
VAL A 218
ALA A 221
ALA A 250
VAL A 253
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.17A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 LEU A 257
GLU A 306
ILE A 309
 None
VD3  A 701 ( 4.8A)
None
 0.12A 3czhA-3c6gA:
65.1		 3czhA-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 ALA A 222
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 1.36A 3czhB-3c6gA:
62.7		 3czhB-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		12 / 12 THR A 119
LEU A 125
ASN A 126
PHE A 214
ALA A 221
ALA A 250
VAL A 253
THR A 314
VAL A 375
ILE A 379
MET A 487
THR A 488
 None
HEM  A 601 (-4.3A)
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 ( 3.8A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.2A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.25A 3czhB-3c6gA:
62.7		 3czhB-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		12 / 12 MET A 118
THR A 119
PHE A 214
VAL A 218
ALA A 221
VAL A 253
TYR A 254
GLU A 306
VAL A 375
ILE A 379
MET A 487
THR A 488
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 ( 4.2A)
None
VD3  A 701 ( 4.8A)
HEM  A 601 ( 4.5A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.12A 3dl9A-3c6gA:
65.3		 3dl9A-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 5 ASN A 126
ALA A 250
LEU A 257
GLY A 305
THR A 314
 VD3  A 701 (-4.2A)
VD3  A 701 (-3.3A)
None
VD3  A 701 ( 3.9A)
HEM  A 601 (-3.4A)
 0.13A 3dl9A-3c6gA:
65.3		 3dl9A-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 MET A 118
THR A 119
ALA A 250
THR A 191
THR A 312
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-3.3A)
HEM  A 601 ( 4.1A)
None
 1.18A 3dl9B-3c6gA:
62.7		 3dl9B-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		12 / 12 MET A 118
THR A 119
ASN A 126
PHE A 214
VAL A 218
ALA A 221
ALA A 250
GLU A 306
THR A 314
ILE A 379
MET A 487
THR A 488
 VD3  A 701 ( 3.9A)
None
VD3  A 701 (-4.2A)
VD3  A 701 (-4.6A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 3.8A)
VD3  A 701 (-3.3A)
VD3  A 701 ( 4.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 4.1A)
VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
 0.19A 3dl9B-3c6gA:
62.7		 3dl9B-3c6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 ALA A 310
THR A 314
CYH A 448
 HEM  A 601 (-3.3A)
HEM  A 601 (-3.4A)
HEM  A 601 (-2.1A)
 0.30A 3e4eA-3c6gA:
48.8		 3e4eA-3c6gA:
37.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 ALA A 310
THR A 314
CYH A 448
 HEM  A 601 (-3.3A)
HEM  A 601 (-3.4A)
HEM  A 601 (-2.1A)
 0.25A 3e4eB-3c6gA:
48.8		 3e4eB-3c6gA:
37.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 MET A 458
CYH A 448
PRO A 440
 HEM  A 601 ( 4.3A)
HEM  A 601 (-2.1A)
None
 1.32A 3h52C-3c6gA:
2.6		 3h52C-3c6gA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 6 ILE A 309
ALA A 310
THR A 314
THR A 488
 None
HEM  A 601 (-3.3A)
HEM  A 601 (-3.4A)
VD3  A 701 ( 4.6A)
 0.42A 3mdrA-3c6gA:
34.6		 3mdrA-3c6gA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 6 ILE A 309
ALA A 310
THR A 314
THR A 488
 None
HEM  A 601 (-3.3A)
HEM  A 601 (-3.4A)
VD3  A 701 ( 4.6A)
 0.41A 3mdrB-3c6gA:
35.7		 3mdrB-3c6gA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 ILE A 309
ALA A 310
GLU A 313
THR A 314
THR A 488
 None
HEM  A 601 (-3.3A)
None
HEM  A 601 (-3.4A)
VD3  A 701 ( 4.6A)
 0.60A 3mdvB-3c6gA:
36.0		 3mdvB-3c6gA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 GLY A  42
LEU A  81
THR A 398
ILE A 394
PHE A  39
 None
 0.95A 3mneA-3c6gA:
2.9		 3mneA-3c6gA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 GLY A  42
LEU A  81
THR A 398
ILE A 394
PHE A  39
 None
 1.03A 3mnoA-3c6gA:
undetectable		 3mnoA-3c6gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 GLY A  42
LEU A  81
THR A 398
ILE A 394
PHE A  39
 None
 1.00A 3mnpA-3c6gA:
2.2		 3mnpA-3c6gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 11 ASP A 278
PHE A 196
HIS A 275
LEU A 300
ILE A 261
 None
 1.41A 3o94A-3c6gA:
undetectable		 3o94A-3c6gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 4 VAL A 368
PHE A 462
PHE A 461
VAL A 187
 None
 1.46A 3rv5C-3c6gA:
1.0
3rv5D-3c6gA:
0.9		 3rv5C-3c6gA:
11.69
3rv5D-3c6gA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 11 LEU A 114
ALA A 250
ILE A 301
GLY A 305
ILE A 309
 None
VD3  A 701 (-3.3A)
None
VD3  A 701 ( 3.9A)
None
 1.09A 3spkA-3c6gA:
undetectable		 3spkA-3c6gA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A 221
LEU A 485
LEU A 377
THR A 399
 None
VD3  A 701 ( 3.8A)
None
None
None
 1.22A 3vhuA-3c6gA:
undetectable		 3vhuA-3c6gA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 SER A 188
ILE A 211
LEU A 257
GLY A 305
VAL A 253
ALA A 250
 None
None
None
VD3  A 701 ( 3.9A)
VD3  A 701 ( 4.2A)
VD3  A 701 (-3.3A)
 1.36A 4foxD-3c6gA:
undetectable		 4foxD-3c6gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		6 / 12 ILE A 309
ILE A 379
LEU A 114
VAL A 226
LEU A 246
THR A 314
 None
HEM  A 601 ( 4.1A)
None
None
None
HEM  A 601 (-3.4A)
 1.44A 4km2B-3c6gA:
undetectable		 4km2B-3c6gA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 8 GLU A 313
GLU A 216
GLU A 219
GLN A 490
LEU A 485
 None
 1.49A 4mj8A-3c6gA:
undetectable		 4mj8A-3c6gA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 6 VAL A 364
LEU A 365
LEU A 466
PHE A 473
 None
 0.97A 4o1zA-3c6gA:
undetectable		 4o1zA-3c6gA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 VAL A 364
ALA A 322
PHE A 420
 None
 0.91A 4olbA-3c6gA:
undetectable		 4olbA-3c6gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		3 / 3 VAL A 364
ALA A 322
PHE A 420
 None
 0.92A 4w5nA-3c6gA:
undetectable		 4w5nA-3c6gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		5 / 12 ILE A 309
LEU A 124
THR A 191
ILE A 195
ILE A 308
 None
HEM  A 601 ( 4.6A)
HEM  A 601 ( 4.1A)
None
None
 1.08A 4x5jA-3c6gA:
undetectable		 4x5jA-3c6gA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 6 VAL A 407
HIS A 408
LEU A 404
LEU A 443
 None
 1.17A 5hrqB-3c6gA:
undetectable
5hrqI-3c6gA:
undetectable
5hrqJ-3c6gA:
undetectable		 5hrqB-3c6gA:
5.83
5hrqI-3c6gA:
5.84
5hrqJ-3c6gA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 4 LEU A 377
ARG A 109
ILE A 401
PHE A 380
 None
HEM  A 601 (-2.4A)
None
None
 1.31A 5kirB-3c6gA:
undetectable		 5kirB-3c6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 7 VAL A  94
PRO A  62
LEU A  61
PHE A  77
 None
 0.73A 6aycA-3c6gA:
33.5		 6aycA-3c6gA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3c6g CYTOCHROME P450 2R1
(Homo
sapiens) 		4 / 6 MET A 487
THR A 488
LEU A 489
LEU A 369
 VD3  A 701 ( 4.5A)
VD3  A 701 ( 4.6A)
None
None
 1.17A 6mvxA-3c6gA:
undetectable
6mvxB-3c6gA:
undetectable
6mvxC-3c6gA:
undetectable		 6mvxA-3c6gA:
21.14
6mvxB-3c6gA:
21.14
6mvxC-3c6gA:
21.14