SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 200
GLY A 202
GLY A 203
ASP A 222
VAL A 225
 MTA  A 401 (-3.7A)
None
None
None
MTA  A 401 (-4.2A)
 0.74A 1n2xB-3c6mA:
14.0		 1n2xB-3c6mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
ILE A 221
ASP A 222
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-3.6A)
 0.58A 1qaoA-3c6mA:
10.9		 1qaoA-3c6mA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 199
GLY A 202
GLY A 203
LEU A 205
 MTA  A 401 (-3.9A)
None
None
None
 0.37A 1qzzA-3c6mA:
14.8		 1qzzA-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 200
GLY A 202
GLY A 203
LEU A 205
 MTA  A 401 (-3.7A)
None
None
None
 0.61A 1qzzA-3c6mA:
14.8		 1qzzA-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 199
GLY A 200
GLU A 220
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 0.59A 1qzzA-3c6mA:
14.8		 1qzzA-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A 222
GLU A 220
LEU A 162
SER A 165
ILE A 282
 None
MTA  A 401 (-2.5A)
None
None
MTA  A 401 (-3.6A)
 1.21A 1rnrB-3c6mA:
undetectable		 1rnrB-3c6mA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 202
GLY A 203
ILE A 221
ASP A 222
ASP A 255
 None
None
MTA  A 401 (-3.8A)
None
MTA  A 401 (-3.6A)
 0.34A 1sqfA-3c6mA:
11.2		 1sqfA-3c6mA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 199
GLY A 200
GLU A 220
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 0.61A 1xdsA-3c6mA:
6.7		 1xdsA-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 199
GLY A 200
GLU A 220
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 0.60A 1xdsB-3c6mA:
13.8		 1xdsB-3c6mA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 4 GLY A  25
SER A  28
VAL A  93
LEU A 100
 None
 1.33A 1yajB-3c6mA:
undetectable		 1yajB-3c6mA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		3 / 3 GLY A 198
GLU A 220
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
SPM  A 501 ( 3.2A)
 0.64A 2b25B-3c6mA:
11.6		 2b25B-3c6mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 ARG A 268
ILE A 221
GLY A 198
ILE A 196
VAL A 259
 None
MTA  A 401 (-3.8A)
MTA  A 401 (-3.3A)
None
None
 1.04A 2b7zB-3c6mA:
undetectable		 2b7zB-3c6mA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 8 GLY A 199
ASP A 201
THR A 178
ILE A 181
 MTA  A 401 (-3.9A)
SPM  A 501 ( 3.8A)
None
None
 0.78A 2f9wA-3c6mA:
2.2
2f9wB-3c6mA:
2.2		 2f9wA-3c6mA:
24.16
2f9wB-3c6mA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
ILE A 221
ASP A 222
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
MTA  A 401 (-3.8A)
None
MTA  A 401 ( 4.4A)
 0.70A 2nxeB-3c6mA:
13.1		 2nxeB-3c6mA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
ILE A 204
ASP A 222
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
None
None
MTA  A 401 ( 4.4A)
 0.91A 2yqzA-3c6mA:
12.6		 2yqzA-3c6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
ILE A 204
ASP A 222
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
None
None
MTA  A 401 ( 4.4A)
 0.89A 2yqzB-3c6mA:
12.5		 2yqzB-3c6mA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 198
GLU A 220
ILE A 221
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.8A)
SPM  A 501 ( 3.2A)
 0.82A 3a7eA-3c6mA:
13.7		 3a7eA-3c6mA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.02A 3b7pA-3c6mA:
25.6		 3b7pA-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
GLN A 315
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 ( 4.0A)
SPM  A 501 (-3.5A)
 0.73A 3b7pA-3c6mA:
25.6		 3b7pA-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.04A 3b7pB-3c6mA:
25.6		 3b7pB-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
GLN A 315
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 ( 4.0A)
SPM  A 501 (-3.5A)
 0.70A 3b7pB-3c6mA:
25.6		 3b7pB-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.05A 3b7pC-3c6mA:
25.5		 3b7pC-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A 148
TYR A 177
GLY A 198
ILE A 221
ASP A 222
VAL A 225
ASP A 255
 MTA  A 401 (-3.5A)
SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.2A)
MTA  A 401 (-3.6A)
 0.41A 3bwcA-3c6mA:
23.8		 3bwcA-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 148
TYR A 177
GLY A 199
ASP A 222
VAL A 225
 MTA  A 401 (-3.5A)
SPM  A 501 (-4.2A)
MTA  A 401 (-3.9A)
None
MTA  A 401 (-4.2A)
 0.98A 3bwcA-3c6mA:
23.8		 3bwcA-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		8 / 12 LEU A 164
TYR A 177
GLY A 198
ASP A 201
ILE A 221
ASP A 222
VAL A 225
ASP A 276
 None
SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
SPM  A 501 ( 3.8A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.2A)
SPM  A 501 ( 3.2A)
 0.46A 3bwcB-3c6mA:
23.6		 3bwcB-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 164
TYR A 177
GLY A 199
ASP A 222
VAL A 225
ASP A 276
 None
SPM  A 501 (-4.2A)
MTA  A 401 (-3.9A)
None
MTA  A 401 (-4.2A)
SPM  A 501 ( 3.2A)
 1.05A 3bwcB-3c6mA:
23.6		 3bwcB-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		6 / 12 TYR A 177
GLY A 198
ASP A 201
ILE A 282
VAL A 225
ASP A 276
 SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
SPM  A 501 ( 3.8A)
MTA  A 401 (-3.6A)
MTA  A 401 (-4.2A)
SPM  A 501 ( 3.2A)
 1.15A 3bwcB-3c6mA:
23.6		 3bwcB-3c6mA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
ILE A 221
ASP A 222
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
MTA  A 401 (-3.8A)
None
MTA  A 401 ( 4.4A)
 0.74A 3cjtO-3c6mA:
13.0		 3cjtO-3c6mA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 ASP A 135
ARG A 122
ILE A 161
SER A 173
 None
 1.12A 3ckzA-3c6mA:
2.1		 3ckzA-3c6mA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 299
SER A 302
LEU A 306
LEU A 335
 None
 0.93A 3f33A-3c6mA:
undetectable		 3f33A-3c6mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
GLU A 220
ASP A 222
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
MTA  A 401 (-2.5A)
None
MTA  A 401 (-3.6A)
 0.51A 3fuuA-3c6mA:
11.8		 3fuuA-3c6mA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 198
GLU A 220
ILE A 221
ASP A 222
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-3.6A)
 0.34A 3grvA-3c6mA:
13.9		 3grvA-3c6mA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLU A 220
ILE A 221
ASP A 222
ASP A 255
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-3.6A)
 0.40A 3gryA-3c6mA:
13.9		 3gryA-3c6mA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
GLY A 202
ASP A 255
LEU A 277
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
None
MTA  A 401 (-3.6A)
MTA  A 401 ( 4.4A)
 0.61A 3ihtA-3c6mA:
11.9		 3ihtA-3c6mA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 4 GLY A 198
GLU A 220
ASP A 255
ASP A 276
 MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
SPM  A 501 ( 3.2A)
 0.81A 3mb5A-3c6mA:
14.7		 3mb5A-3c6mA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 200
GLU A 220
ASP A 255
ASP A 276
 MTA  A 401 (-3.7A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
SPM  A 501 ( 3.2A)
 0.69A 3vywC-3c6mA:
14.7		 3vywC-3c6mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		3 / 3 GLU A 220
ASP A 222
ASP A 255
 MTA  A 401 (-2.5A)
None
MTA  A 401 (-3.6A)
 0.36A 4gc9A-3c6mA:
8.7		 4gc9A-3c6mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 199
GLY A 200
ASP A 201
LEU A 170
ILE A 196
 MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 4.3A)
None
 1.13A 4pghA-3c6mA:
12.0		 4pghA-3c6mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 199
GLY A 200
ASP A 201
LEU A 170
ILE A 196
 MTA  A 401 (-3.9A)
MTA  A 401 (-3.7A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 4.3A)
None
 1.08A 4pghD-3c6mA:
12.1		 4pghD-3c6mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		3 / 4 ARG A 268
GLY A 267
GLU A 266
 None
 0.59A 4z2dB-3c6mA:
undetectable
4z2dC-3c6mA:
2.4		 4z2dB-3c6mA:
22.05
4z2dC-3c6mA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 4 VAL A 280
ALA A 279
ASN A 317
GLN A 315
 None
SPM  A 501 ( 4.5A)
None
SPM  A 501 ( 4.0A)
 1.43A 4zgfA-3c6mA:
undetectable		 4zgfA-3c6mA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 200
GLY A 202
LEU A 205
LEU A 195
 MTA  A 401 (-3.3A)
MTA  A 401 (-3.7A)
None
None
None
 0.95A 5c0oF-3c6mA:
12.3		 5c0oF-3c6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 201
ASN A 160
PHE A 158
 SPM  A 501 ( 3.8A)
None
None
 0.73A 5dsgB-3c6mA:
undetectable		 5dsgB-3c6mA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		4 / 6 TYR A 177
GLY A 198
GLU A 220
ASP A 255
 SPM  A 501 (-4.2A)
MTA  A 401 (-3.3A)
MTA  A 401 (-2.5A)
MTA  A 401 (-3.6A)
 1.30A 5emlA-3c6mA:
3.4		 5emlA-3c6mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.18A 5yn6A-3c6mA:
8.6		 5yn6A-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.92A 5yn6A-3c6mA:
8.6		 5yn6A-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.16A 5yniA-3c6mA:
8.5		 5yniA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.87A 5yniA-3c6mA:
8.5		 5yniA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.15A 5ynmA-3c6mA:
8.6		 5ynmA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.88A 5ynmA-3c6mA:
8.6		 5ynmA-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A 148
GLY A 198
ILE A 221
ASP A 222
VAL A 225
ASP A 255
LEU A 277
 MTA  A 401 (-3.5A)
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.2A)
MTA  A 401 (-3.6A)
MTA  A 401 ( 4.4A)
 0.54A 6bq4A-3c6mA:
23.0		 6bq4A-3c6mA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A 148
GLY A 198
ILE A 221
ASP A 222
VAL A 225
ASP A 255
LEU A 277
 MTA  A 401 (-3.5A)
MTA  A 401 (-3.3A)
MTA  A 401 (-3.8A)
None
MTA  A 401 (-4.2A)
MTA  A 401 (-3.6A)
MTA  A 401 ( 4.4A)
 0.47A 6bq4B-3c6mA:
23.3		 6bq4B-3c6mA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3c6m SPERMINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 199
SER A 145
GLN A 148
ILE A 221
ASP A 255
 MTA  A 401 (-3.9A)
None
MTA  A 401 (-3.5A)
MTA  A 401 (-3.8A)
MTA  A 401 (-3.6A)
 1.19A 6bxnB-3c6mA:
2.8		 6bxnB-3c6mA:
21.67