SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 7 GLN A 173
ASP A 174
LEU A 160
SER A 152
 None
None
None
GDP  A 361 (-3.2A)
 0.92A 1ig3A-3c7kA:
undetectable
1ig3B-3c7kA:
2.3		 1ig3A-3c7kA:
21.70
1ig3B-3c7kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		3 / 3 GLN A  68
LYS A  70
VAL A  72
 None
 0.84A 2jfaB-3c7kA:
undetectable		 2jfaB-3c7kA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		5 / 12 LYS A  51
TYR A  69
VAL A  72
VAL A 186
ASP A 201
 GDP  A 361 ( 4.5A)
None
None
None
MG  A 362 ( 4.5A)
 1.41A 2x0yA-3c7kA:
3.2		 2x0yA-3c7kA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3c7k REGULATOR OF
G-PROTEIN SIGNALING
16
(Mus
musculus) 		3 / 3 ALA B 154
THR B 158
CYH B  97
 None
 0.77A 3e4eA-3c7kB:
undetectable		 3e4eA-3c7kB:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		5 / 12 ALA A  87
ASN A 142
LEU A 149
LEU A 157
TYR A  95
 None
 1.05A 3fl9B-3c7kA:
undetectable		 3fl9B-3c7kA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		5 / 12 ALA A  87
ASN A 142
LEU A 149
LEU A 157
TYR A  95
 None
 1.11A 3fl9G-3c7kA:
undetectable		 3fl9G-3c7kA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 7 LEU A 284
LEU A 269
ILE A 279
PHE A 275
 None
 0.92A 3ln1B-3c7kA:
undetectable		 3ln1B-3c7kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		3 / 3 LEU A 248
HIS A 245
MET A 244
 None
 0.83A 3thrD-3c7kA:
3.2		 3thrD-3c7kA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3c7k REGULATOR OF
G-PROTEIN SIGNALING
16
(Mus
musculus) 		4 / 8 ILE B 121
ILE B 131
THR B 135
THR B 139
 None
 0.66A 4em2A-3c7kB:
undetectable		 4em2A-3c7kB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		6 / 12 GLY A  45
GLY A  42
GLY A 204
SER A  44
ALA A 326
THR A 327
 GDP  A 361 (-2.8A)
ALF  A 365 (-3.0A)
ALF  A 365 (-3.2A)
GDP  A 361 (-4.0A)
GDP  A 361 (-3.4A)
GDP  A 361 (-3.4A)
 1.30A 4uckA-3c7kA:
undetectable		 4uckA-3c7kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		3 / 3 ASP A 232
LEU A  91
ARG A 143
 None
 0.94A 5e8qA-3c7kA:
undetectable		 5e8qA-3c7kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		3 / 3 LYS A 272
GLN A 333
ASN A 330
 None
 1.03A 5l2tA-3c7kA:
1.2		 5l2tA-3c7kA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 6 VAL A  66
LYS A  70
ILE A 175
TYR A 168
 None
 1.31A 5q1sA-3c7kA:
2.8		 5q1sA-3c7kA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 9 VAL A 111
ASP A 116
LEU A 149
SER A 152
 None
None
None
GDP  A 361 (-3.2A)
 0.96A 6c2mD-3c7kA:
undetectable		 6c2mD-3c7kA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3c7k REGULATOR OF
G-PROTEIN SIGNALING
16
(Mus
musculus) 		3 / 3 PHE B 117
ARG B 136
ALA B 154
 None
 0.90A 6ecfB-3c7kB:
undetectable		 6ecfB-3c7kB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
(Mus
musculus) 		4 / 5 LEU A 235
ILE A 265
MET A 244
GLY A 230
 None
 1.00A 6hd6A-3c7kA:
undetectable		 6hd6A-3c7kA:
12.01