SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		4 / 6 ALA A 119
LYS A 122
ASP A 126
ALA A 127
 CL  A 200 ( 4.1A)
None
None
None
 0.45A 1iwhA-3c7mA:
undetectable		 1iwhA-3c7mA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 11 GLN A 161
MET A   8
VAL A 163
ALA A 165
SER A 154
 None
 1.38A 2c12B-3c7mA:
undetectable		 2c12B-3c7mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 10 GLN A 161
MET A   8
VAL A 163
ALA A 165
SER A 154
 None
 1.45A 2c12D-3c7mA:
0.0		 2c12D-3c7mA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		3 / 3 SER A 181
ASP A   6
ASP A 187
 None
None
CD  A 198 (-2.1A)
 0.67A 2plwA-3c7mA:
undetectable		 2plwA-3c7mA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		4 / 7 ALA A  99
ALA A 103
ARG A 110
TYR A  27
 None
None
CL  A 204 ( 3.7A)
None
 0.97A 2ql8A-3c7mA:
undetectable
2ql8B-3c7mA:
undetectable		 2ql8A-3c7mA:
20.00
2ql8B-3c7mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 PHE A 135
THR A 147
PHE A  25
ALA A  96
PHE A  72
 None
None
CL  A 206 ( 4.5A)
None
None
 1.46A 3apxA-3c7mA:
undetectable		 3apxA-3c7mA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 GLY A 124
ALA A  99
PHE A 120
ILE A 121
VAL A  71
 None
 1.20A 4azsA-3c7mA:
undetectable		 4azsA-3c7mA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ALA A  28
TYR A 101
PHE A  93
GLY A  65
ASP A  36
 None
None
CL  A 206 (-4.6A)
None
CL  A 206 ( 4.4A)
 1.10A 4mm4A-3c7mA:
undetectable		 4mm4A-3c7mA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		4 / 8 TYR A 101
PHE A  98
GLY A  41
ILE A 182
 None
 0.95A 4qoiA-3c7mA:
undetectable
4qoiB-3c7mA:
undetectable		 4qoiA-3c7mA:
22.00
4qoiB-3c7mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		4 / 6 ILE A 174
LYS A   1
LEU A 192
GLU A 191
 None
 0.83A 4w5nA-3c7mA:
undetectable		 4w5nA-3c7mA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.12A 5n0oA-3c7mA:
undetectable		 5n0oA-3c7mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.12A 5n0oB-3c7mA:
undetectable		 5n0oB-3c7mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.09A 5n0rA-3c7mA:
undetectable		 5n0rA-3c7mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.10A 5n0wA-3c7mA:
undetectable		 5n0wA-3c7mA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.10A 5n0xA-3c7mA:
undetectable		 5n0xA-3c7mA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE
(Escherichia
coli) 		5 / 12 ILE A  14
GLY A 170
VAL A  51
ALA A 153
VAL A  24
 None
 1.09A 5n4iA-3c7mA:
undetectable		 5n4iA-3c7mA:
18.84