SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 11 GLY A 299
ASP A 265
ILE A 262
GLY A 259
ILE A 258
 None
None
CL  A 332 ( 4.3A)
None
None
 0.95A 1n49B-3c7tA:
undetectable		 1n49B-3c7tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 12 ASN A 191
GLU A 228
ARG A 236
MET A 230
ILE A 286
 None
 1.33A 1s14A-3c7tA:
undetectable		 1s14A-3c7tA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 12 ASN A 191
GLU A 228
ARG A 236
MET A 230
ILE A 286
 None
 1.33A 1s14B-3c7tA:
undetectable		 1s14B-3c7tA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		6 / 10 ARG A  73
GLY A 299
ASP A 265
ILE A 262
GLY A 259
ILE A 258
 None
None
None
CL  A 332 ( 4.3A)
None
None
 1.19A 1sh9B-3c7tA:
undetectable		 1sh9B-3c7tA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 12 ASN A 191
GLU A 228
ARG A 236
MET A 230
ILE A 286
 None
 1.35A 3lpsA-3c7tA:
undetectable		 3lpsA-3c7tA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 11 ASN A 191
GLU A 228
ARG A 236
MET A 230
ILE A 286
 None
 1.39A 4urnB-3c7tA:
undetectable		 4urnB-3c7tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 11 ASN A 191
GLU A 228
ARG A 236
MET A 230
ILE A 286
 None
 1.32A 4urnC-3c7tA:
undetectable		 4urnC-3c7tA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 10 GLY A 171
GLU A 141
PHE A 168
LEU A  78
ALA A 146
 None
 1.32A 4wnuD-3c7tA:
undetectable		 4wnuD-3c7tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		4 / 5 PHE A 233
GLY A 237
ILE A 262
LEU A 186
 None
None
CL  A 332 ( 4.3A)
None
 0.93A 5dzkd-3c7tA:
undetectable
5dzkk-3c7tA:
undetectable
5dzky-3c7tA:
undetectable		 5dzkd-3c7tA:
20.94
5dzkk-3c7tA:
19.62
5dzky-3c7tA:
0.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 11 ALA A 165
THR A 164
VAL A 153
GLY A 140
GLY A 171
 None
 0.91A 5lf7K-3c7tA:
undetectable
5lf7L-3c7tA:
undetectable		 5lf7K-3c7tA:
18.22
5lf7L-3c7tA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE
(Bombyx
mori) 		5 / 11 ALA A 165
THR A 164
VAL A 153
GLY A 140
GLY A 171
 None
 0.93A 5lf7Y-3c7tA:
undetectable
5lf7Z-3c7tA:
undetectable		 5lf7Y-3c7tA:
18.22
5lf7Z-3c7tA:
24.91