SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 7 GLY A 222
TYR A 225
LEU A 231
ALA A 228
 None
 0.78A 1dmaA-3c8eA:
undetectable		 1dmaA-3c8eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 6 GLU A 127
LEU A 125
VAL A  58
MET A  61
 None
 1.02A 1hk1A-3c8eA:
2.9		 1hk1A-3c8eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 7 ALA A 126
GLU A 127
LEU A 125
VAL A  58
MET A  61
 None
 1.25A 1hk2A-3c8eA:
2.7		 1hk2A-3c8eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLU A  63
ARG A 254
ARG A 272
GLU A  74
ALA A  73
 None
 1.44A 1mj2C-3c8eA:
undetectable		 1mj2C-3c8eA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLU A  63
ARG A 254
ARG A 272
GLU A  74
ALA A  73
 None
 1.49A 1mjoB-3c8eA:
undetectable		 1mjoB-3c8eA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 6 ALA A 103
LEU A 104
ILE A 121
SER A  49
 None
 0.92A 1sbrA-3c8eA:
undetectable
1sbrB-3c8eA:
undetectable		 1sbrA-3c8eA:
21.92
1sbrB-3c8eA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 10 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.38A 3fhjB-3c8eA:
undetectable		 3fhjB-3c8eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 10 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.40A 3fhjC-3c8eA:
undetectable		 3fhjC-3c8eA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.37A 3fi0A-3c8eA:
undetectable		 3fi0A-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.39A 3fi0C-3c8eA:
undetectable		 3fi0C-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.42A 3fi0F-3c8eA:
undetectable		 3fi0F-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.39A 3fi0H-3c8eA:
undetectable		 3fi0H-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.47A 3fi0J-3c8eA:
undetectable		 3fi0J-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.42A 3fi0K-3c8eA:
undetectable		 3fi0K-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.40A 3fi0L-3c8eA:
undetectable		 3fi0L-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.33A 3fi0M-3c8eA:
undetectable		 3fi0M-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.39A 3fi0N-3c8eA:
undetectable		 3fi0N-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 9 GLY A 217
GLN A 240
VAL A 220
ILE A 212
VAL A 246
 None
 1.38A 3fi0O-3c8eA:
undetectable		 3fi0O-3c8eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ASP A 106
LEU A  62
LEU A 104
SER A 120
 None
 0.92A 3lm8A-3c8eA:
undetectable
3lm8C-3c8eA:
undetectable		 3lm8A-3c8eA:
24.17
3lm8C-3c8eA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 12 ILE A 121
GLY A  72
ALA A  73
LEU A 104
LEU A  47
 None
 0.84A 4o1zA-3c8eA:
0.0		 4o1zA-3c8eA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		3 / 3 ASP A 209
TYR A 205
TRP A 242
 None
 1.34A 4p7nA-3c8eA:
undetectable		 4p7nA-3c8eA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 7 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.92A 4zdzA-3c8eA:
undetectable		 4zdzA-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 7 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.92A 4ze3A-3c8eA:
undetectable		 4ze3A-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.89A 5esfA-3c8eA:
undetectable		 5esfA-3c8eA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.88A 5esjA-3c8eA:
undetectable		 5esjA-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.81A 5hs1A-3c8eA:
2.2		 5hs1A-3c8eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 5 TYR A 167
LEU A 157
GLY A 158
PHE A 161
 None
None
GSH  A 290 (-3.4A)
None
 0.93A 5kmdC-3c8eA:
2.4
5kmdD-3c8eA:
2.5		 5kmdC-3c8eA:
22.57
5kmdD-3c8eA:
22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_A_ACTA311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 4 GLY A  41
ASP A  76
TRP A  78
HIS A 273
 None
 0.04A 5uunA-3c8eA:
39.1		 5uunA-3c8eA:
59.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		3 / 3 LEU A  50
ILE A  82
TYR A 167
 None
GSH  A 289 (-3.7A)
None
 0.31A 5uunB-3c8eA:
39.3		 5uunB-3c8eA:
59.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 4 PHE A  22
PRO A  53
TYR A 167
TYR A 225
 GSH  A 290 ( 3.9A)
None
None
None
 0.42A 5uunB-3c8eA:
39.3		 5uunB-3c8eA:
59.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 12 ALA A 168
PRO A 169
GLY A  20
LYS A 171
GLY A 158
 None
None
None
None
GSH  A 290 (-3.4A)
 1.26A 5wwsB-3c8eA:
undetectable		 5wwsB-3c8eA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 4 ARG A 254
SER A 276
ASP A 274
HIS A  43
 None
 1.41A 5zhmA-3c8eA:
0.5		 5zhmA-3c8eA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 4 ILE A 176
LEU A 231
HIS A 166
ALA A 227
 None
 0.98A 6ck2C-3c8eA:
undetectable
6ck2D-3c8eA:
undetectable		 6ck2C-3c8eA:
7.56
6ck2D-3c8eA:
9.17