SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		5 / 12 LEU A 183
GLY A 240
TYR A 239
ILE A 196
THR A 228
 None
 1.04A 1p91B-3c8fA:
undetectable		 1p91B-3c8fA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 8 TYR A  35
CYH A  36
GLU A  79
VAL A 168
 None
SF4  A 500 (-2.2A)
None
None
 0.80A 2fb2A-3c8fA:
14.9		 2fb2A-3c8fA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 7 GLY A  71
THR A  14
MET A  66
SER A  11
 None
PGE  A 502 ( 4.3A)
None
None
 1.13A 2o5yH-3c8fA:
undetectable
2o5yL-3c8fA:
undetectable		 2o5yH-3c8fA:
20.22
2o5yL-3c8fA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 7 LEU A 119
VAL A 122
THR A 123
VAL A  73
 None
 0.96A 2qblA-3c8fA:
undetectable		 2qblA-3c8fA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 8 GLU A  79
ARG A 166
VAL A 126
LEU A 103
 None
MT2  A 501 (-3.1A)
None
None
 0.71A 3ax7A-3c8fA:
undetectable		 3ax7A-3c8fA:
10.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		5 / 12 TYR A  35
HIS A  37
LYS A 131
VAL A 168
TYR A 201
 None
MT2  A 501 (-4.2A)
SF4  A 500 (-3.7A)
None
None
 0.74A 3cb8A-3c8fA:
38.0		 3cb8A-3c8fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		7 / 12 TYR A  35
SER A  76
ASP A 104
LYS A 131
ARG A 166
VAL A 168
TYR A 201
 None
MT2  A 501 ( 4.0A)
MT2  A 501 (-4.2A)
SF4  A 500 (-3.7A)
MT2  A 501 (-3.1A)
None
None
 1.00A 3cb8A-3c8fA:
38.0		 3cb8A-3c8fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		7 / 12 TYR A  35
SER A  76
GLU A  79
ASP A 104
LYS A 131
VAL A 168
TYR A 201
 None
MT2  A 501 ( 4.0A)
None
MT2  A 501 (-4.2A)
SF4  A 500 (-3.7A)
None
None
 0.58A 3cb8A-3c8fA:
38.0		 3cb8A-3c8fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		6 / 12 TYR A  35
SER A  76
GLU A  79
LYS A 131
VAL A 168
LEU A 199
 None
MT2  A 501 ( 4.0A)
None
SF4  A 500 (-3.7A)
None
None
 0.94A 3cb8A-3c8fA:
38.0		 3cb8A-3c8fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 7 GLU A  79
ARG A 166
VAL A 126
LEU A 103
 None
MT2  A 501 (-3.1A)
None
None
 0.71A 3uniA-3c8fA:
undetectable		 3uniA-3c8fA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 8 GLU A  79
ARG A 166
VAL A 126
LEU A 103
 None
MT2  A 501 (-3.1A)
None
None
 0.69A 3uniB-3c8fA:
undetectable		 3uniB-3c8fA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 5 GLU A  79
LEU A 103
VAL A 126
PHE A 152
 None
 0.89A 4lb0B-3c8fA:
undetectable		 4lb0B-3c8fA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		4 / 5 VAL A 109
HIS A 138
LEU A  30
CYH A  29
 None
None
None
SF4  A 500 (-2.2A)
 1.28A 5vcvA-3c8fA:
undetectable		 5vcvA-3c8fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		5 / 12 LEU A 204
GLY A 205
HIS A 207
CYH A  36
ASP A  40
 None
None
None
SF4  A 500 (-2.2A)
None
 1.23A 6bxlA-3c8fA:
undetectable		 6bxlA-3c8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		5 / 12 LEU A 204
GLY A 205
HIS A 207
SER A  76
ASP A  40
 None
None
None
MT2  A 501 ( 4.0A)
None
 1.21A 6bxlA-3c8fA:
undetectable		 6bxlA-3c8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME
(Escherichia
coli) 		5 / 12 LEU A 204
GLY A 205
HIS A 207
CYH A  36
ASP A  40
 None
None
None
SF4  A 500 (-2.2A)
None
 1.36A 6bxlB-3c8fA:
undetectable		 6bxlB-3c8fA:
20.59