SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1376_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	3c8o	REGULATOR OF RIBONUCLEASE ACTIVITY A (Pseudomonas aeruginosa)	4 / 8	LEU A 74 LEU A 78 LYS A 81 ALA A 82	None EDO A 166 (-4.2A) EDO A 170 ( 4.9A) None	0.91A	2wekA-3c8oA: undetectable	2wekA-3c8oA: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R6W_A_NFZA214_1 (FMN-DEPENDENT NADH-AZOREDUCTASE 1)	3c8o	REGULATOR OF RIBONUCLEASE ACTIVITY A (Pseudomonas aeruginosa)	5 / 10	PHE A 138 VAL A 60 PHE A 32 GLY A 150 ASN A 148	None None None PEG A 190 ( 4.0A) None	1.38A	3r6wA-3c8oA: undetectable 3r6wB-3c8oA: undetectable	3r6wA-3c8oA: 19.56 3r6wB-3c8oA: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KR1_B_017B101_2 (PROTEASE PR5-DRV)	3c8o	REGULATOR OF RIBONUCLEASE ACTIVITY A (Pseudomonas aeruginosa)	4 / 8	GLY A 67 ASP A 64 VAL A 91 GLY A 134	EDO A 177 (-4.3A) None None None	0.66A	5kr1B-3c8oA: undetectable	5kr1B-3c8oA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T2Z_B_017B201_2 (PROTEASE)	3c8o	REGULATOR OF RIBONUCLEASE ACTIVITY A (Pseudomonas aeruginosa)	5 / 12	GLY A 67 ASP A 64 VAL A 91 GLY A 134 SER A 24	EDO A 177 (-4.3A) None None None PEG A 191 (-3.5A)	0.67A	5t2zB-3c8oA: undetectable	5t2zB-3c8oA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BXN_B_SAMB901_0 (DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2)	3c8o	REGULATOR OF RIBONUCLEASE ACTIVITY A (Pseudomonas aeruginosa)	5 / 12	GLY A 66 SER A 46 LYS A 121 CYH A 41 ILE A 39	None PEG A 186 (-3.8A) EDO A 174 (-3.7A) None None	1.40A	6bxnB-3c8oA: undetectable	6bxnB-3c8oA: 23.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WEK_A_DIFA1376_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","3c8o","REGULATOR OF RIBONUCLEASE ACTIVITY A","Pseudomonas aeruginosa",4,"LEU A  74;LEU A  78;LYS A  81;ALA A  82","None;EDO A 166 (-4.2A);EDO A 170 ( 4.9A);None","0.91A","2wekA-3c8oA:undetectable","2wekA-3c8oA:18.55"],["3R6W_A_NFZA214_1","FMN-DEPENDENT NADH-AZOREDUCTASE 1;FMN-DEPENDENT NADH-AZOREDUCTASE 1","3c8o","REGULATOR OF RIBONUCLEASE ACTIVITY A","Pseudomonas aeruginosa",5,"PHE A 138;VAL A  60;PHE A  32;GLY A 150;ASN A 148","None;None;None;PEG A 190 ( 4.0A);None","1.38A","3r6wA-3c8oA:undetectable;3r6wB-3c8oA:undetectable","3r6wA-3c8oA:19.56;3r6wB-3c8oA:19.56"],["5KR1_B_017B101_2","PROTEASE PR5-DRV","3c8o","REGULATOR OF RIBONUCLEASE ACTIVITY A","Pseudomonas aeruginosa",4,"GLY A  67;ASP A  64;VAL A  91;GLY A 134","EDO A 177 (-4.3A);None;None;None","0.66A","5kr1B-3c8oA:undetectable","5kr1B-3c8oA:19.50"],["5T2Z_B_017B201_2","PROTEASE","3c8o","REGULATOR OF RIBONUCLEASE ACTIVITY A","Pseudomonas aeruginosa",5,"GLY A  67;ASP A  64;VAL A  91;GLY A 134;SER A  24","EDO A 177 (-4.3A);None;None;None;PEG A 191 (-3.5A)","0.67A","5t2zB-3c8oA:undetectable","5t2zB-3c8oA:22.22"],["6BXN_B_SAMB901_0","DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2","3c8o","REGULATOR OF RIBONUCLEASE ACTIVITY A","Pseudomonas aeruginosa",5,"GLY A  66;SER A  46;LYS A 121;CYH A  41;ILE A  39","None;PEG A 186 (-3.8A);EDO A 174 (-3.7A);None;None","1.40A","6bxnB-3c8oA:undetectable","6bxnB-3c8oA:23.27"]]