SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		3 / 3 TRP A 180
ALA A 183
VAL A 179
 None
 0.87A 1bdwA-3c8tA:
undetectable
1bdwB-3c8tA:
undetectable		 1bdwA-3c8tA:
5.33
1bdwB-3c8tA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 4 THR A 247
LEU A 251
VAL A 254
LEU A 258
 None
 0.64A 1fbmD-3c8tA:
undetectable		 1fbmD-3c8tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 THR A 247
LEU A 251
VAL A 254
LEU A 258
 None
 0.72A 1fbmE-3c8tA:
undetectable		 1fbmE-3c8tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 4 THR A 247
LEU A 251
VAL A 254
LEU A 258
 None
 0.79A 1mz9D-3c8tA:
undetectable		 1mz9D-3c8tA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA888_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 PRO A 158
MET A 159
ALA A 160
GLU A 275
 None
 1.44A 1qhsA-3c8tA:
0.0		 1qhsA-3c8tA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 11 LEU A 111
ALA A  55
ALA A  51
VAL A  97
LEU A  94
 None
 1.17A 1rlbF-3c8tA:
undetectable		 1rlbF-3c8tA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.96A 1t3rA-3c8tA:
undetectable		 1t3rA-3c8tA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.95A 1t7iA-3c8tA:
undetectable		 1t7iA-3c8tA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		3 / 3 ALA A 183
VAL A 179
TRP A 180
 None
 0.87A 1w5uA-3c8tA:
undetectable
1w5uB-3c8tA:
undetectable		 1w5uA-3c8tA:
5.33
1w5uB-3c8tA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 11 LEU A 135
VAL A 254
ALA A 345
LEU A 349
ARG A 139
 None
 1.28A 2bxgA-3c8tA:
2.7		 2bxgA-3c8tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		3 / 3 TRP A 180
ALA A 183
VAL A 179
 None
 0.82A 2izqC-3c8tA:
undetectable
2izqD-3c8tA:
undetectable		 2izqC-3c8tA:
5.33
2izqD-3c8tA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 11 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.90A 2nnpA-3c8tA:
undetectable		 2nnpA-3c8tA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 8 LEU A 133
ARG A 139
LEU A 349
VAL A 309
GLY A 341
 None
 1.37A 2po5B-3c8tA:
undetectable		 2po5B-3c8tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 7 SER A 298
CYH A 299
GLN A 360
ILE A 265
 None
 1.10A 2xz5A-3c8tA:
undetectable
2xz5B-3c8tA:
undetectable		 2xz5A-3c8tA:
19.48
2xz5B-3c8tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 8 SER A 298
CYH A 299
GLN A 360
ILE A 265
 None
 1.12A 2xz5B-3c8tA:
undetectable
2xz5E-3c8tA:
undetectable		 2xz5B-3c8tA:
19.48
2xz5E-3c8tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 6 ASP A 264
ILE A 265
LEU A 359
GLU A 275
 None
 0.97A 2ya7A-3c8tA:
undetectable		 2ya7A-3c8tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 6 ASP A 264
ILE A 265
LEU A 359
GLU A 275
 None
 0.94A 2ya7B-3c8tA:
undetectable		 2ya7B-3c8tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 6 ASP A 264
ILE A 265
LEU A 359
GLU A 275
 None
 0.95A 2ya7D-3c8tA:
undetectable		 2ya7D-3c8tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 1.00A 3ektA-3c8tA:
undetectable		 3ektA-3c8tA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.97A 3gguB-3c8tA:
undetectable		 3gguB-3c8tA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 PHE A 173
GLY A 174
TYR A 350
GLY A 358
LEU A 147
 None
 0.82A 3hs6B-3c8tA:
undetectable		 3hs6B-3c8tA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.94A 3oy4B-3c8tA:
undetectable		 3oy4B-3c8tA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 8 ALA A 379
VAL A 382
LEU A 386
LEU A 401
 None
 0.74A 3roxA-3c8tA:
undetectable		 3roxA-3c8tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.93A 3s53A-3c8tA:
undetectable		 3s53A-3c8tA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 11 ALA A 381
VAL A 399
ALA A 387
LEU A 413
LEU A 435
 None
 1.04A 3sm2B-3c8tA:
undetectable		 3sm2B-3c8tA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 1.03A 3u7sB-3c8tA:
undetectable		 3u7sB-3c8tA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.97A 4dqbB-3c8tA:
undetectable		 4dqbB-3c8tA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.96A 4dqcB-3c8tA:
undetectable		 4dqcB-3c8tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.97A 4dqeB-3c8tA:
undetectable		 4dqeB-3c8tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.96A 4dqhB-3c8tA:
undetectable		 4dqhB-3c8tA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.97A 4njtB-3c8tA:
undetectable		 4njtB-3c8tA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 ILE A 302
LEU A 303
ASP A 264
GLU A 278
 None
 0.89A 4nkxB-3c8tA:
undetectable		 4nkxB-3c8tA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.93A 4q1wA-3c8tA:
undetectable		 4q1wA-3c8tA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 10 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.93A 4q1yA-3c8tA:
undetectable		 4q1yA-3c8tA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 11 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 0.99A 4qgiA-3c8tA:
undetectable		 4qgiA-3c8tA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 LEU A 150
ALA A 177
LEU A 261
ALA A 352
ALA A 146
 None
 1.26A 4x1iB-3c8tA:
undetectable		 4x1iB-3c8tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		6 / 12 GLN A 351
ILE A 348
GLY A 259
VAL A 276
LEU A 359
PRO A 279
 None
 1.36A 5ergB-3c8tA:
undetectable		 5ergB-3c8tA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 9 GLY A 341
ALA A 343
ASP A  27
GLY A 132
ILE A 129
 None
 1.03A 5kr0B-3c8tA:
undetectable		 5kr0B-3c8tA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 6 LEU A 213
ALA A 115
LEU A 210
SER A 204
 None
 1.28A 5l4iB-3c8tA:
undetectable		 5l4iB-3c8tA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 ILE A 348
PHE A 184
SER A 257
ALA A 352
 None
 1.27A 5msdA-3c8tA:
undetectable		 5msdA-3c8tA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		5 / 12 SER A 212
ALA A 206
PHE A 203
LEU A 224
VAL A 220
 None
 1.24A 5tudD-3c8tA:
undetectable		 5tudD-3c8tA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 5 GLU A  45
THR A  46
HIS A 112
LEU A  96
 None
 1.24A 5utuH-3c8tA:
undetectable		 5utuH-3c8tA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3c8t FUMARATE LYASE
(Chelativorans
sp.
BNC1) 		4 / 6 MET A 355
ALA A 177
LEU A 147
ALA A 146
 None
 1.05A 6fosB-3c8tA:
2.0		 6fosB-3c8tA:
10.76