SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 6 LEU A   7
ILE A 454
TYR A 457
VAL A  74
 None
 1.05A 1db1A-3c8vA:
undetectable		 1db1A-3c8vA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 12 GLY A 260
ALA A 261
GLY A 295
VAL A 274
ILE A 275
 None
 0.96A 1hsgB-3c8vA:
undetectable		 1hsgB-3c8vA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 10 ALA A 290
ILE A 275
GLY A 276
GLY A 293
THR A 315
 None
 1.00A 1k6cA-3c8vA:
undetectable		 1k6cA-3c8vA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 PHE A 419
LEU A 204
VAL A 165
SER A 168
 EDO  A 484 (-3.7A)
None
None
None
 1.10A 1wrlA-3c8vA:
undetectable
1wrlB-3c8vA:
undetectable		 1wrlA-3c8vA:
11.30
1wrlB-3c8vA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		3 / 3 HIS A 317
ILE A 426
LEU A 280
 EDO  A 490 (-4.1A)
None
None
 0.71A 2kceA-3c8vA:
undetectable		 2kceA-3c8vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 GLY A 319
GLY A 318
VAL A 354
LEU A 338
 None
 0.79A 2oa1B-3c8vA:
undetectable		 2oa1B-3c8vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		3 / 3 SER A  77
HIS A  55
ASP A 107
 None
 0.86A 2oxtA-3c8vA:
undetectable		 2oxtA-3c8vA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 12 ILE A 159
ILE A 149
ILE A  11
VAL A  74
VAL A  72
 None
 0.98A 2ygoA-3c8vA:
undetectable		 2ygoA-3c8vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		3 / 3 LEU A 204
VAL A 401
ARG A 409
 None
None
EDO  A 485 (-4.0A)
 0.81A 3b0wB-3c8vA:
undetectable		 3b0wB-3c8vA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		3 / 3 LEU A 384
GLU A 367
ILE A 348
 None
 0.60A 3czhA-3c8vA:
undetectable		 3czhA-3c8vA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 10 ILE A 469
ILE A 471
VAL A  54
GLY A  70
LEU A  63
 None
 1.27A 3em0A-3c8vA:
undetectable		 3em0A-3c8vA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 12 PHE A 415
GLY A 340
ALA A 324
ILE A 330
MET A 355
 None
 1.48A 3ld6B-3c8vA:
undetectable		 3ld6B-3c8vA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 5 VAL A 165
ILE A 198
PHE A 415
PHE A 419
 None
EDO  A 484 ( 4.5A)
None
EDO  A 484 (-3.7A)
 1.02A 3owxB-3c8vA:
undetectable		 3owxB-3c8vA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 8 ASP A 459
GLN A 458
PRO A 462
GLN A   3
 None
 0.94A 3oyaA-3c8vA:
undetectable		 3oyaA-3c8vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 12 PHE A 419
HIS A 357
LEU A 338
PHE A 331
TYR A 180
 EDO  A 484 (-3.7A)
None
None
EDO  A 483 (-4.4A)
None
 1.48A 3vn2A-3c8vA:
undetectable		 3vn2A-3c8vA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 5 LEU A 280
HIS A 124
GLU A 300
HIS A 317
 None
None
None
EDO  A 490 (-4.1A)
 1.33A 4a7bB-3c8vA:
undetectable		 4a7bB-3c8vA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		3 / 3 VAL A 181
SER A 157
MET A 144
 None
 0.86A 5ikqA-3c8vA:
undetectable		 5ikqA-3c8vA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 8 ALA A 285
GLN A 283
SER A 282
HIS A 317
 None
None
None
EDO  A 490 (-4.1A)
 0.99A 5km8A-3c8vA:
undetectable
5km8B-3c8vA:
undetectable		 5km8A-3c8vA:
14.35
5km8B-3c8vA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 8 THR A 121
SER A  82
THR A 141
SER A 116
 None
 0.91A 5l4eA-3c8vA:
undetectable
5l4eB-3c8vA:
undetectable
5l4eC-3c8vA:
undetectable
5l4eD-3c8vA:
undetectable
5l4eE-3c8vA:
undetectable		 5l4eA-3c8vA:
21.16
5l4eB-3c8vA:
21.16
5l4eC-3c8vA:
21.16
5l4eD-3c8vA:
21.16
5l4eE-3c8vA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 8 THR A 141
SER A 116
THR A 121
SER A  82
 None
 0.94A 5l4eA-3c8vA:
undetectable
5l4eB-3c8vA:
undetectable
5l4eC-3c8vA:
undetectable
5l4eD-3c8vA:
undetectable
5l4eE-3c8vA:
undetectable		 5l4eA-3c8vA:
21.16
5l4eB-3c8vA:
21.16
5l4eC-3c8vA:
21.16
5l4eD-3c8vA:
21.16
5l4eE-3c8vA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 THR A 164
LEU A 215
VAL A 230
GLU A 222
 None
 1.14A 5tudA-3c8vA:
undetectable		 5tudA-3c8vA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 8 ILE A 359
THR A 164
VAL A 165
SER A 161
 None
 1.17A 6fbvC-3c8vA:
undetectable		 6fbvC-3c8vA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3c8v PUTATIVE
ACETYLTRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 GLN A 472
PHE A  56
HIS A  57
VAL A  74
 None
 1.01A 6hu9S-3c8vA:
undetectable
6hu9q-3c8vA:
undetectable		 6hu9S-3c8vA:
13.21
6hu9q-3c8vA:
13.79