SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		4 / 7 GLU A  98
MET A  61
PHE A 123
ALA A 250
 None
None
LCK  A 125 ( 4.1A)
None
 1.02A 1linA-3c8wA:
undetectable		 1linA-3c8wA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		4 / 8 LEU A 127
PHE A  81
ARG A 118
GLY A 116
 None
LCK  A 125 ( 4.4A)
LCK  A 125 (-3.9A)
None
 0.89A 3b9lA-3c8wA:
undetectable		 3b9lA-3c8wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		4 / 8 ARG A 118
PHE A 107
TYR A 145
PRO A 124
 LCK  A 125 (-3.9A)
None
None
LCK  A 125 ( 3.2A)
 1.26A 3jq7B-3c8wA:
undetectable		 3jq7B-3c8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		5 / 9 ILE A  73
LEU A 243
ARG A 118
LEU A 127
GLY A 116
 None
None
LCK  A 125 (-3.9A)
None
None
 1.32A 3nxuB-3c8wA:
undetectable		 3nxuB-3c8wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		4 / 5 VAL A 171
LEU A 198
LEU A 241
ILE A  73
 None
 0.90A 4a9jB-3c8wA:
undetectable		 4a9jB-3c8wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		4 / 5 VAL A 171
LEU A 198
LEU A 241
ILE A  73
 None
 0.86A 4a9jC-3c8wA:
undetectable		 4a9jC-3c8wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		5 / 12 HIS A 218
ILE A 148
ALA A 128
ILE A 223
PHE A 107
 None
 1.45A 4rp9A-3c8wA:
undetectable		 4rp9A-3c8wA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		3 / 3 TYR A  34
THR A 242
THR A  79
 None
 0.69A 5aoxB-3c8wA:
undetectable		 5aoxB-3c8wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		3 / 3 TYR A  34
THR A 242
THR A  79
 None
 0.69A 5aoxE-3c8wA:
undetectable		 5aoxE-3c8wA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 3c8w ACETOACETATE
DECARBOXYLASE ADC
(Legionella
pneumophila) 		4 / 5 SER A 105
GLN A  89
LEU A 215
PHE A  70
 None
 1.33A 5evyX-3c8wA:
0.0		 5evyX-3c8wA:
20.51