SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		6 / 11 GLY A  44
HIS A  52
HIS A  55
GLY A 249
ASP A 251
ILE A 283
 None
5CA  A 418 ( 4.9A)
5CA  A 418 (-4.3A)
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
5CA  A 418 (-4.4A)
 0.86A 1jzsA-3c8zA:
16.9		 1jzsA-3c8zA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A  52
GLY A  54
HIS A  55
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
5CA  A 418 (-4.3A)
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 0.42A 1pg2A-3c8zA:
23.7		 1pg2A-3c8zA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  52
GLY A  54
HIS A  55
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
5CA  A 418 (-4.3A)
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 0.74A 1qu2A-3c8zA:
8.3		 1qu2A-3c8zA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A 203
VAL A 160
TRP A 206
 None
 0.81A 1tkqB-3c8zA:
undetectable		 1tkqB-3c8zA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TYR A  78
THR A  58
TYR A  59
LEU A 252
 None
5CA  A 418 (-3.6A)
None
5CA  A 418 (-3.9A)
 1.47A 1uw6A-3c8zA:
undetectable
1uw6B-3c8zA:
undetectable		 1uw6A-3c8zA:
19.18
1uw6B-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TYR A  78
THR A  58
TYR A  59
LEU A 252
 None
5CA  A 418 (-3.6A)
None
5CA  A 418 (-3.9A)
 1.48A 1uw6D-3c8zA:
undetectable
1uw6E-3c8zA:
undetectable		 1uw6D-3c8zA:
19.18
1uw6E-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TYR A  78
THR A  58
TYR A  59
LEU A 252
 None
5CA  A 418 (-3.6A)
None
5CA  A 418 (-3.9A)
 1.46A 1uw6G-3c8zA:
undetectable
1uw6H-3c8zA:
undetectable		 1uw6G-3c8zA:
19.18
1uw6H-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 TYR A  78
THR A  58
TYR A  59
LEU A 252
 None
5CA  A 418 (-3.6A)
None
5CA  A 418 (-3.9A)
 1.46A 1uw6P-3c8zA:
undetectable
1uw6Q-3c8zA:
undetectable		 1uw6P-3c8zA:
19.18
1uw6Q-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 252
TYR A  78
THR A  58
TYR A  59
 5CA  A 418 (-3.9A)
None
5CA  A 418 (-3.6A)
None
 1.44A 1uw6P-3c8zA:
undetectable
1uw6T-3c8zA:
undetectable		 1uw6P-3c8zA:
19.18
1uw6T-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A  52
GLY A  54
HIS A  55
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
5CA  A 418 (-4.3A)
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 0.44A 2x1lA-3c8zA:
22.7		 2x1lA-3c8zA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  52
GLY A  54
HIS A  55
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
5CA  A 418 (-4.3A)
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 0.36A 2x1lB-3c8zA:
24.2		 2x1lB-3c8zA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 HIS A  52
GLY A  54
HIS A  55
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
5CA  A 418 (-4.3A)
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 0.39A 2x1lC-3c8zA:
24.1		 2x1lC-3c8zA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASN A 337
ALA A 312
ALA A 336
ARG A 339
 None
 1.40A 3kp2B-3c8zA:
undetectable		 3kp2B-3c8zA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A  87
ASP A  86
GLY A 226
THR A 130
 None
 0.91A 3tl9B-3c8zA:
undetectable		 3tl9B-3c8zA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 PHE A 185
LYS A 197
SER A 198
 None
 1.09A 3tyeB-3c8zA:
undetectable		 3tyeB-3c8zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 TYR A 126
GLU A 107
GLN A 109
PRO A  88
 None
 1.31A 3ugrA-3c8zA:
undetectable		 3ugrA-3c8zA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_1
(MNMC2)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 213
ASP A  86
ASP A 159
GLU A 230
 None
 1.40A 3vywB-3c8zA:
2.2		 3vywB-3c8zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A 200
ARG A 178
ASP A 191
LEU A 201
 None
 1.21A 4ax8A-3c8zA:
undetectable		 4ax8A-3c8zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A 412
TRP A 343
VAL A 404
VAL A 400
 None
 0.97A 4em2A-3c8zA:
undetectable		 4em2A-3c8zA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 101
ASP A  99
TRP A 100
 None
 1.06A 4xdqA-3c8zA:
undetectable		 4xdqA-3c8zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  52
GLY A  54
TYR A  48
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
None
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 1.14A 5hg0A-3c8zA:
5.7		 5hg0A-3c8zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 HIS A  52
GLY A  54
HIS A  55
TYR A  48
GLY A 249
ASP A 251
 5CA  A 418 ( 4.9A)
5CA  A 418 (-3.3A)
5CA  A 418 (-4.3A)
None
5CA  A 418 (-3.0A)
5CA  A 418 (-3.1A)
 1.10A 5hg0B-3c8zA:
5.7		 5hg0B-3c8zA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A  64
LEU A  68
MET A  40
TYR A  59
 None
 1.39A 5uc3A-3c8zA:
undetectable		 5uc3A-3c8zA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A  83
GLU A 230
HIS A 228
 5CA  A 418 (-3.4A)
None
None
 0.91A 5xioA-3c8zA:
undetectable		 5xioA-3c8zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  60
GLY A 281
ILE A 313
LEU A  53
GLY A  54
 None
None
None
None
5CA  A 418 (-3.3A)
 0.87A 5zhmB-3c8zA:
undetectable		 5zhmB-3c8zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A 233
VAL A  79
TYR A  41
 None
 0.67A 5zmqH-3c8zA:
undetectable		 5zmqH-3c8zA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3c8z CYSTEINYL-TRNA
SYNTHETASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A  55
ARG A 304
ASP A 114
GLU A 113
 5CA  A 418 (-4.3A)
None
None
None
 1.20A 6mn4C-3c8zA:
undetectable		 6mn4C-3c8zA:
23.08