SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ca8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		3 / 3 TRP A 247
ALA A  16
VAL A 243
 None
 0.91A 1bdwA-3ca8A:
undetectable
1bdwB-3ca8A:
undetectable		 1bdwA-3ca8A:
6.09
1bdwB-3ca8A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 12 ARG A 158
GLN A 151
GLU A  98
GLY A  69
ALA A  43
 SO4  A 802 (-3.1A)
None
None
None
None
 1.17A 1httD-3ca8A:
undetectable		 1httD-3ca8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 10 ALA A 259
LEU A 256
LEU A 209
VAL A 205
ILE A  14
 None
 1.12A 2w9gA-3ca8A:
undetectable		 2w9gA-3ca8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		6 / 10 ALA A 259
LEU A 256
LEU A 209
VAL A 205
SER A  10
ILE A  14
 None
 1.47A 2w9hA-3ca8A:
undetectable		 2w9hA-3ca8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 11 ALA A 259
LEU A 256
LEU A 209
VAL A 205
ILE A  14
 None
 1.08A 3frbX-3ca8A:
undetectable		 3frbX-3ca8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 9 LEU A 256
LEU A 209
VAL A 205
SER A  10
ILE A  14
 None
 1.26A 3freX-3ca8A:
undetectable		 3freX-3ca8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 11 THR A 213
LEU A 219
VAL A 243
ILE A  20
LEU A 250
 None
 1.47A 4lhmA-3ca8A:
undetectable		 4lhmA-3ca8A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		4 / 5 SER A  30
ARG A 158
GLU A 215
ARG A 164
 None
SO4  A 802 (-3.1A)
None
None
 1.17A 5cdqA-3ca8A:
undetectable
5cdqB-3ca8A:
2.7
5cdqC-3ca8A:
undetectable		 5cdqA-3ca8A:
19.29
5cdqB-3ca8A:
22.59
5cdqC-3ca8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 9 LEU A 216
LEU A 250
ILE A  17
LEU A 256
MET A 260
 None
 1.20A 5g48B-3ca8A:
undetectable		 5g48B-3ca8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		4 / 5 ILE A 105
HIS A  85
HIS A  87
TYR A  88
 None
None
MPD  A 908 (-3.8A)
MPD  A 908 (-4.3A)
 1.35A 5ocsA-3ca8A:
0.7		 5ocsA-3ca8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		4 / 5 ILE A 105
HIS A  85
HIS A  87
TYR A  88
 None
None
MPD  A 908 (-3.8A)
MPD  A 908 (-4.3A)
 1.34A 5ocsC-3ca8A:
undetectable		 5ocsC-3ca8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		4 / 6 PRO A 153
GLY A 181
LEU A 199
VAL A  47
 None
MPD  A 901 (-3.5A)
MPD  A 901 ( 4.8A)
MPD  A 902 ( 4.3A)
 0.89A 5x80A-3ca8A:
undetectable
5x80B-3ca8A:
undetectable		 5x80A-3ca8A:
19.17
5x80B-3ca8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3ca8 PROTEIN YDCF
(Escherichia
coli) 		5 / 12 GLY A 181
ASN A 197
PHE A 195
THR A 154
TYR A 208
 MPD  A 901 (-3.5A)
None
None
None
None
 1.37A 5yf0A-3ca8A:
undetectable		 5yf0A-3ca8A:
17.87