SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 7 LEU A 203
HIS A 207
ASN A 132
TYR A 259
 None
 0.93A 1afsA-3caxA:
undetectable		 1afsA-3caxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 7 LEU A 203
HIS A 207
ASN A 132
TYR A 259
 None
 0.94A 1afsB-3caxA:
undetectable		 1afsB-3caxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		3 / 3 GLU A 304
HIS A 301
ASP A 344
 None
 0.80A 1i9gA-3caxA:
undetectable		 1i9gA-3caxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 8 LEU A 203
ASN A 132
GLU A 183
HIS A 179
 None
 0.99A 2bnnA-3caxA:
undetectable
2bnnB-3caxA:
undetectable		 2bnnA-3caxA:
18.67
2bnnB-3caxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.21A 2hrcB-3caxA:
undetectable		 2hrcB-3caxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		6 / 12 LEU A 119
LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.45A 2pnjA-3caxA:
undetectable		 2pnjA-3caxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 11 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.28A 2po5B-3caxA:
undetectable		 2po5B-3caxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.24A 2po7B-3caxA:
undetectable		 2po7B-3caxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.28A 2qd4B-3caxA:
undetectable		 2qd4B-3caxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 5 PRO A 299
VAL A 297
THR A 127
GLY A 122
 None
 1.17A 3elzB-3caxA:
undetectable		 3elzB-3caxA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 ALA A 324
ILE A 257
ASN A 255
LEU A 203
TYR A 180
 None
 1.01A 3nrrA-3caxA:
undetectable		 3nrrA-3caxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 ALA A 324
ILE A 257
ASN A 255
LEU A 203
TYR A 180
 None
 0.97A 3nrrB-3caxA:
undetectable		 3nrrB-3caxA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 ALA A 146
PHE A 236
ILE A 214
ALA A 244
VAL A 169
 None
 0.83A 3rukB-3caxA:
undetectable		 3rukB-3caxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 ALA A 146
PHE A 236
ILE A 214
ALA A 244
VAL A 169
 None
 0.90A 4nkvB-3caxA:
undetectable		 4nkvB-3caxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 12 ALA A 146
PHE A 236
ILE A 214
ALA A 244
VAL A 169
 None
 0.87A 4nkvC-3caxA:
undetectable		 4nkvC-3caxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 11 TYR A 259
LEU A 262
LEU A 203
ILE A 274
PHE A 258
 None
 1.09A 4odrA-3caxA:
undetectable
4odrB-3caxA:
undetectable		 4odrA-3caxA:
17.07
4odrB-3caxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 8 ILE A 161
PHE A 232
LEU A 149
LEU A 221
 None
 0.86A 4qopC-3caxA:
undetectable		 4qopC-3caxA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		5 / 10 ALA A 240
LEU A 142
SER A 248
LEU A 247
ALA A 139
 None
 1.13A 4zbrA-3caxA:
3.2		 4zbrA-3caxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 5 ILE A 411
ILE A 369
TYR A 438
GLU A 453
 None
 1.03A 4zzcE-3caxA:
4.4		 4zzcE-3caxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		3 / 3 GLU A 304
HIS A 301
ASP A 344
 None
 0.74A 5c0oG-3caxA:
undetectable		 5c0oG-3caxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 6 ALA A 139
LEU A 142
ILE A 168
TYR A 284
 None
 0.69A 5mvmB-3caxA:
4.5
5mvmC-3caxA:
4.5		 5mvmB-3caxA:
13.13
5mvmC-3caxA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3cax UNCHARACTERIZED
PROTEIN PF0695
(Pyrococcus
furiosus) 		4 / 5 GLU A 254
HIS A 179
LEU A 172
VAL A 175
 None
 1.09A 6bc9A-3caxA:
undetectable		 6bc9A-3caxA:
15.05