SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Brucella
melitensis) 		5 / 12 LEU A  60
ILE A  59
CYH A 131
VAL A  33
LEU A  46
 None
None
None
None
FMN  A 200 (-3.8A)
 1.12A 2bxfB-3cb0A:
undetectable		 2bxfB-3cb0A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Brucella
melitensis) 		5 / 12 PHE A 107
LEU A 161
TYR A 168
ALA A  94
SER A  96
 None
None
None
None
FMN  A 200 (-4.0A)
 1.37A 4a83A-3cb0A:
undetectable		 4a83A-3cb0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Brucella
melitensis) 		5 / 12 PHE A 107
LEU A 161
TYR A 168
ALA A  94
SER A  96
 None
None
None
None
FMN  A 200 (-4.0A)
 1.36A 4a84A-3cb0A:
undetectable		 4a84A-3cb0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Brucella
melitensis) 		5 / 7 LEU A 122
LEU A  84
ALA A  92
ALA A  94
ALA A 110
 None
 1.46A 4z90F-3cb0A:
undetectable
4z90G-3cb0A:
undetectable
4z90H-3cb0A:
undetectable
4z90J-3cb0A:
undetectable		 4z90F-3cb0A:
17.18
4z90G-3cb0A:
17.18
4z90H-3cb0A:
17.18
4z90J-3cb0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Brucella
melitensis) 		4 / 5 LEU A 122
PHE A  95
LEU A  84
TRP A 112
 None
 1.34A 5m10A-3cb0A:
undetectable		 5m10A-3cb0A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Brucella
melitensis) 		5 / 12 LEU A  46
HIS A 142
LEU A  63
LEU A  44
THR A  45
 FMN  A 200 (-3.8A)
None
FMN  A 200 (-4.8A)
FMN  A 200 (-4.3A)
FMN  A 200 (-4.4A)
 1.00A 6b0cD-3cb0A:
undetectable		 6b0cD-3cb0A:
18.34