SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 8 CYH A  54
ASP A  56
CYH A  68
GLY A  70
 ZN  A1001 (-2.3A)
None
ZN  A1001 (-2.3A)
None
 0.92A 1ekjA-3cbbA:
undetectable
1ekjB-3cbbA:
undetectable		 1ekjA-3cbbA:
18.58
1ekjB-3cbbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 8 CYH A  54
ASP A  56
CYH A  68
GLY A  70
 ZN  A1001 (-2.3A)
None
ZN  A1001 (-2.3A)
None
 0.89A 1ekjG-3cbbA:
undetectable
1ekjH-3cbbA:
undetectable		 1ekjG-3cbbA:
18.58
1ekjH-3cbbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A  52
GLY A  70
CYH A  71
LYS A  72
 None
None
ZN  A1001 (-2.3A)
None
 1.27A 2yldA-3cbbA:
undetectable		 2yldA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A 114
GLY A  55
CYH A  51
LYS A  49
 None
None
ZN  A1001 (-2.4A)
None
 1.44A 2yldA-3cbbA:
undetectable		 2yldA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A 114
GLY A  55
CYH A  51
LYS A  49
 None
None
ZN  A1001 (-2.4A)
None
 1.26A 2ylgA-3cbbA:
undetectable		 2ylgA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A  52
GLY A  70
CYH A  71
LYS A  72
 None
None
ZN  A1001 (-2.3A)
None
 1.29A 3zwiA-3cbbA:
undetectable		 3zwiA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A 114
GLY A  55
CYH A  51
LYS A  49
 None
None
ZN  A1001 (-2.4A)
None
 1.42A 3zwiA-3cbbA:
undetectable		 3zwiA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A  52
GLY A  70
CYH A  71
LYS A  72
 None
None
ZN  A1001 (-2.3A)
None
 1.19A 5jliA-3cbbA:
undetectable		 5jliA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A 114
GLY A  55
CYH A  51
LYS A  49
 None
None
ZN  A1001 (-2.4A)
None
 1.25A 5jliA-3cbbA:
undetectable		 5jliA-3cbbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 3cbb HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA, DNA
BINDING DOMAIN
(Homo
sapiens) 		4 / 5 ALA A 114
GLY A  55
CYH A  51
LYS A  49
 None
None
ZN  A1001 (-2.4A)
None
 1.29A 5jt4A-3cbbA:
undetectable		 5jt4A-3cbbA:
16.95