SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 4 LEU A  82
LEU A  76
SER A  74
LEU A  52
None
None
SAH  A 301 (-2.9A)
None
1.17A 1ya3A-3cbgA:
undetectable
1ya3A-3cbgA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
8 / 12 GLY A  68
PHE A  70
TYR A  73
SER A  74
ALA A 121
ALA A 144
ASP A 145
TYR A 152
SAH  A 301 (-3.7A)
SAH  A 301 (-4.8A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
None
0.58A 2avdA-3cbgA:
30.9
2avdA-3cbgA:
39.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
7 / 12 GLY A  68
PHE A  70
TYR A  73
ALA A 121
ASP A 143
ALA A 144
TYR A 152
SAH  A 301 (-3.7A)
SAH  A 301 (-4.8A)
None
SAH  A 301 (-3.4A)
MG  A 401 ( 2.7A)
SAH  A 301 (-3.4A)
None
0.66A 2avdB-3cbgA:
31.1
2avdB-3cbgA:
39.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 6 LEU A  82
ALA A  61
SER A  57
THR A  59
None
1.07A 3cfqA-3cbgA:
undetectable
3cfqA-3cbgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 5 LEU A 134
GLN A  63
LEU A 159
GLU A 136
None
1.06A 3h5gA-3cbgA:
undetectable
3h5gB-3cbgA:
undetectable
3h5gA-3cbgA:
10.11
3h5gB-3cbgA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 9 LEU A 159
PHE A 137
ILE A  89
ALA A 121
THR A 124
None
None
None
SAH  A 301 (-3.4A)
None
0.85A 3mdtA-3cbgA:
undetectable
3mdtA-3cbgA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 LEU A 159
PHE A 137
ILE A  89
ALA A 121
THR A 124
None
None
None
SAH  A 301 (-3.4A)
None
0.90A 3mdvB-3cbgA:
undetectable
3mdvB-3cbgA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 THR A 124
ILE A  88
PHE A 141
ALA A  75
VAL A  69
None
1.13A 3nvkI-3cbgA:
14.1
3nvkI-3cbgA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 10 MET A  42
GLU A  66
GLY A  68
SER A  74
ASP A 143
FER  A 501 (-3.7A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
SAH  A 301 (-2.9A)
MG  A 401 ( 2.7A)
0.37A 3s68A-3cbgA:
21.5
3s68A-3cbgA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 10 MET A  42
ASP A 143
LYS A 146
ASP A 169
ASN A 170
FER  A 501 (-3.7A)
MG  A 401 ( 2.7A)
4FE  A 502 ( 2.6A)
MG  A 401 (-3.4A)
MG  A 401 (-2.5A)
0.36A 3s68A-3cbgA:
21.6
3s68A-3cbgA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 6 LEU A  82
ALA A  61
SER A  57
THR A  59
None
1.05A 4i89A-3cbgA:
undetectable
4i89A-3cbgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 7 VAL A 203
ALA A 217
MET A 166
ASP A 196
None
0.83A 4l9iA-3cbgA:
undetectable
4l9iA-3cbgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 LEU A 160
LEU A 157
GLY A 156
VAL A 167
ILE A  89
None
1.04A 4ok1A-3cbgA:
undetectable
4ok1A-3cbgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 LEU A 160
LEU A 157
GLY A 156
VAL A 167
ILE A  89
None
1.07A 4oktA-3cbgA:
undetectable
4oktA-3cbgA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
6 / 12 GLN A  43
GLY A  68
ASP A  94
ALA A 121
ALA A 144
TYR A 152
SAH  A 301 (-4.4A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
None
0.81A 4pclA-3cbgA:
27.8
4pclA-3cbgA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
6 / 12 GLN A  43
GLU A  66
GLY A  68
ALA A 121
ALA A 144
TYR A 152
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
None
0.34A 4pclB-3cbgA:
28.1
4pclB-3cbgA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 10 MET A  42
ASP A 143
LYS A 146
ASP A 169
ASN A 170
FER  A 501 (-3.7A)
MG  A 401 ( 2.7A)
4FE  A 502 ( 2.6A)
MG  A 401 (-3.4A)
MG  A 401 (-2.5A)
0.31A 4pylA-3cbgA:
22.2
4pylA-3cbgA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
3 / 3 ASP A 212
HIS A 174
LYS A   3
None
4FE  A 502 ( 4.3A)
None
0.90A 4qzuD-3cbgA:
undetectable
4qzuD-3cbgA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 11 GLU A 126
LEU A 128
ASN A 158
LEU A 159
LEU A  65
None
1.00A 4wg0E-3cbgA:
undetectable
4wg0F-3cbgA:
undetectable
4wg0G-3cbgA:
undetectable
4wg0E-3cbgA:
5.33
4wg0F-3cbgA:
5.33
4wg0G-3cbgA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 7 ASN A 158
LEU A 159
GLU A 126
LEU A 128
None
0.79A 4wg0L-3cbgA:
undetectable
4wg0M-3cbgA:
undetectable
4wg0L-3cbgA:
5.33
4wg0M-3cbgA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 5 GLY A  68
TYR A  73
SER A  74
ASP A 143
SAH  A 301 (-3.7A)
None
SAH  A 301 (-2.9A)
MG  A 401 ( 2.7A)
0.41A 4xueA-3cbgA:
21.9
4xueA-3cbgA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 GLY A  68
TYR A  73
ALA A 121
ALA A 144
TYR A 152
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
None
0.37A 4ymgA-3cbgA:
25.5
4ymgA-3cbgA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
7 / 12 GLY A  68
TYR A  73
SER A  74
ALA A 121
ASP A 143
ALA A 144
TYR A 152
SAH  A 301 (-3.7A)
None
SAH  A 301 (-2.9A)
SAH  A 301 (-3.4A)
MG  A 401 ( 2.7A)
SAH  A 301 (-3.4A)
None
0.33A 4ymgB-3cbgA:
25.2
4ymgB-3cbgA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 8 ILE A  67
GLY A  68
PHE A  51
ASP A 169
None
SAH  A 301 (-3.7A)
None
MG  A 401 (-3.4A)
0.80A 5hieD-3cbgA:
undetectable
5hieD-3cbgA:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
9 / 12 MET A  42
GLU A  66
GLY A  68
TYR A  73
ALA A 121
ASP A 143
ALA A 144
ASP A 145
TYR A 152
FER  A 501 (-3.7A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.4A)
MG  A 401 ( 2.7A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
None
0.62A 5kvaA-3cbgA:
30.3
5kvaA-3cbgA:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
9 / 12 MET A  42
GLU A  66
GLY A  68
TYR A  73
ALA A 121
ASP A 143
ALA A 144
ASP A 145
TYR A 152
FER  A 501 (-3.7A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.4A)
MG  A 401 ( 2.7A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
None
0.67A 5kvaB-3cbgA:
30.1
5kvaB-3cbgA:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
6 / 6 MET A  42
ASP A 143
LYS A 146
ASP A 169
ASN A 170
TRP A 173
FER  A 501 (-3.7A)
MG  A 401 ( 2.7A)
4FE  A 502 ( 2.6A)
MG  A 401 (-3.4A)
MG  A 401 (-2.5A)
None
0.34A 5logA-3cbgA:
31.8
5logA-3cbgA:
46.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
7 / 12 GLU A  66
GLY A  68
TYR A  73
ALA A 121
PHE A 141
ALA A 144
TYR A 152
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.4A)
None
0.28A 5n5dA-3cbgA:
27.5
5n5dA-3cbgA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
6 / 12 GLU A  66
TYR A  73
ALA A 121
PHE A 141
ALA A 144
TYR A 152
SAH  A 301 ( 4.4A)
None
SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.4A)
None
0.26A 5n5dB-3cbgA:
28.6
5n5dB-3cbgA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 7 GLY A  68
PHE A  70
SER A  74
ASP A 143
SAH  A 301 (-3.7A)
SAH  A 301 (-4.8A)
SAH  A 301 (-2.9A)
MG  A 401 ( 2.7A)
0.34A 5n5dB-3cbgA:
28.6
5n5dB-3cbgA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
4 / 8 GLU A 154
VAL A 203
GLY A 156
LEU A 160
None
1.06A 5sxqB-3cbgA:
undetectable
5sxqB-3cbgA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
SAH  A 301 (-3.7A)
SAH  A 301 (-4.5A)
None
MG  A 401 (-3.4A)
SAH  A 301 (-3.0A)
1.36A 5yn6A-3cbgA:
9.1
5yn6A-3cbgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
SAH  A 301 (-3.7A)
SAH  A 301 (-4.5A)
None
MG  A 401 (-3.4A)
SAH  A 301 (-3.0A)
1.32A 5yniA-3cbgA:
8.9
5yniA-3cbgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
SAH  A 301 (-3.7A)
SAH  A 301 (-4.5A)
None
MG  A 401 (-3.4A)
SAH  A 301 (-3.0A)
1.32A 5ynmA-3cbgA:
9.0
5ynmA-3cbgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 GLU A  66
GLY A  68
TYR A  73
ALA A 121
ALA A 144
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
0.43A 5zw4A-3cbgA:
26.1
5zw4A-3cbgA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)
3cbg O-METHYLTRANSFERASE
(Synechocystis
sp.
PCC
6803)
5 / 12 PHE A 141
ILE A  44
TYR A 149
LEU A  52
LEU A 216
None
SAH  A 301 (-3.5A)
None
None
None
1.42A 5zwrB-3cbgA:
undetectable
5zwrB-3cbgA:
24.27