SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		9 / 10 ILE A 223
ALA A 226
GLU A 228
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.20A 1n6aA-3cboA:
39.4		 1n6aA-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.29A 1n6cA-3cboA:
36.4		 1n6cA-3cboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 292
LEU A 291
TRP A 352
ASN A 296
ALA A 295
 None
None
SAH  A   1 (-3.9A)
SAH  A   1 (-3.3A)
None
 1.01A 3av6A-3cboA:
undetectable		 3av6A-3cboA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.33A 3mekA-3cboA:
7.5		 3mekA-3cboA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.33A 3qwpA-3cboA:
6.4		 3qwpA-3cboA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 ALA A 226
GLY A 227
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.84A 3qxyA-3cboA:
6.5		 3qxyA-3cboA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 ALA A 226
GLY A 227
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.84A 3rc0B-3cboA:
6.5		 3rc0B-3cboA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 131
ARG A 152
GLY A 157
ALA A 145
ALA A 170
 None
 0.97A 3sugA-3cboA:
undetectable		 3sugA-3cboA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.26A 4e47A-3cboA:
38.1		 4e47A-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.27A 4e47B-3cboA:
38.2		 4e47B-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.24A 4e47C-3cboA:
38.3		 4e47C-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 10 ILE A 223
ALA A 226
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.22A 4e47D-3cboA:
38.4		 4e47D-3cboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 10 LEU A 230
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 None
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 1.35A 4ij8A-3cboA:
12.2
4ij8B-3cboA:
12.9		 4ij8A-3cboA:
23.11
4ij8B-3cboA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 11 ILE A 223
ALA A 226
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.26A 4j83A-3cboA:
39.0		 4j83A-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.31A 4jdsA-3cboA:
38.0		 4jdsA-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.29A 4jdsB-3cboA:
38.2		 4jdsB-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.26A 4jdsC-3cboA:
38.3		 4jdsC-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 11 ILE A 223
ALA A 226
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.21A 4jdsD-3cboA:
38.5		 4jdsD-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		11 / 12 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.33A 4jlgA-3cboA:
38.5		 4jlgA-3cboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 11 ILE A 223
ALA A 226
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.39A 4jlgB-3cboA:
38.2		 4jlgB-3cboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		3 / 3 GLU A 212
ILE A 275
ALA A 295
 None
 0.60A 4wnwB-3cboA:
undetectable		 4wnwB-3cboA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 5 TYR A 245
GLY A 264
TYR A 305
TYR A 335
GLY A 336
 None
SAH  A   1 (-4.0A)
None
SAH  A   1 (-4.9A)
None
 0.42A 5ayfA-3cboA:
38.2		 5ayfA-3cboA:
94.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.55A 5ayfA-3cboA:
38.2		 5ayfA-3cboA:
94.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		10 / 11 ILE A 223
ALA A 226
GLY A 227
GLU A 228
GLY A 264
ASN A 265
LYS A 294
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.9A)
SAH  A   1 (-4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-2.7A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.23A 5ayfA-3cboA:
38.2		 5ayfA-3cboA:
94.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.35A 5cclA-3cboA:
6.3		 5cclA-3cboA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.35A 5ccmA-3cboA:
6.9		 5ccmA-3cboA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 10 PHE A 159
ALA A 154
LEU A 155
GLY A 167
LEU A 269
 None
 1.12A 5oy01-3cboA:
undetectable
5oy07-3cboA:
undetectable		 5oy01-3cboA:
17.28
5oy07-3cboA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 9 LEU A 230
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 None
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 1.41A 5tegA-3cboA:
13.0
5tegD-3cboA:
undetectable		 5tegA-3cboA:
24.80
5tegD-3cboA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 10 GLY A 227
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 SAH  A   1 ( 4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 0.89A 5tegB-3cboA:
13.0
5tegE-3cboA:
undetectable		 5tegB-3cboA:
24.80
5tegE-3cboA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 10 LEU A 230
ASN A 296
HIS A 297
TYR A 335
TRP A 352
 None
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
SAH  A   1 (-3.9A)
 1.39A 5tegB-3cboA:
13.0
5tegE-3cboA:
undetectable		 5tegB-3cboA:
24.80
5tegE-3cboA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		4 / 7 TRP A 120
VAL A 147
TYR A 122
GLU A 151
 None
 1.22A 5umwA-3cboA:
undetectable
5umwF-3cboA:
undetectable		 5umwA-3cboA:
14.81
5umwF-3cboA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.33A 5v37A-3cboA:
7.8		 5v37A-3cboA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.31A 5xxdA-3cboA:
6.5		 5xxdA-3cboA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.29A 5xxgA-3cboA:
7.1		 5xxgA-3cboA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.31A 5xxjA-3cboA:
7.4		 5xxjA-3cboA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 227
ASN A 265
ASN A 296
HIS A 297
TYR A 335
 SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
None
SAH  A   1 (-4.9A)
 0.29A 5yjoA-3cboA:
7.4		 5yjoA-3cboA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 ILE A 160
GLY A 157
ALA A 170
ALA A 145
PHE A 182
 None
 1.06A 5zw4A-3cboA:
undetectable		 5zw4A-3cboA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLN A 253
THR A 251
VAL A 274
ARG A 258
SER A 257
 None
 1.47A 6ak3A-3cboA:
undetectable		 6ak3A-3cboA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 12 GLY A 127
VAL A 147
PHE A 182
PRO A 180
GLY A 178
 None
 1.11A 6brdC-3cboA:
undetectable		 6brdC-3cboA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		4 / 7 ALA A 226
GLY A 227
GLY A 264
ASN A 296
 SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
 0.40A 6nm4A-3cboA:
8.9		 6nm4A-3cboA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7
(Homo
sapiens) 		5 / 9 ILE A 223
ALA A 226
GLY A 227
GLY A 264
ASN A 296
 SAH  A   1 ( 4.3A)
SAH  A   1 (-3.7A)
SAH  A   1 ( 4.0A)
SAH  A   1 (-4.0A)
SAH  A   1 (-3.3A)
 0.37A 6nm4B-3cboA:
8.8		 6nm4B-3cboA:
24.59