SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OA1_B_ADNB2005_1 (TRYPTOPHAN HALOGENASE)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	4 / 7	GLY A 144 GLY A 143 VAL A 61 LEU A 59	GLY A 144 ( 0.0A) GLY A 143 ( 0.0A) VAL A 61 ( 0.6A) LEU A 59 ( 0.6A)	0.78A	2oa1B-3cbtA: undetectable	2oa1B-3cbtA: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K9F_H_LFXH0_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	4 / 6	ARG A 110 GLY A 112 GLU A 197 GLU A 113	ARG A 110 (-0.6A) GLY A 112 ( 0.0A) GLU A 197 ( 0.6A) GLU A 113 (-0.5A)	1.12A	3k9fA-3cbtA: undetectable 3k9fB-3cbtA: undetectable 3k9fD-3cbtA: undetectable	3k9fA-3cbtA: 17.64 3k9fB-3cbtA: 17.64 3k9fD-3cbtA: 18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_B_DVAB8_0 (GRAMICIDIN D)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	3 / 3	VAL A 156 VAL A 132 TRP A 130	VAL A 156 ( 0.6A) VAL A 132 ( 0.6A) TRP A 130 (-0.5A)	0.72A	3l8lA-3cbtA: undetectable 3l8lB-3cbtA: undetectable	3l8lA-3cbtA: 7.55 3l8lB-3cbtA: 8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU9_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	3 / 3	GLN A 172 THR A 87 THR A 90	GLN A 172 ( 0.6A) THR A 87 ( 0.8A) THR A 90 ( 0.8A)	0.74A	4fu9A-3cbtA: undetectable	4fu9A-3cbtA: 19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUF_A_ACTA310_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	3 / 3	GLN A 172 THR A 87 THR A 90	GLN A 172 ( 0.6A) THR A 87 ( 0.8A) THR A 90 ( 0.8A)	0.72A	4fufA-3cbtA: undetectable	4fufA-3cbtA: 19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESH_A_1YNA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	4 / 5	TRP A 130 LEU A 58 PRO A 204 LEU A 138	TRP A 130 (-0.5A) LEU A 58 ( 0.6A) PRO A 204 (-1.1A) LEU A 138 ( 0.6A)	1.36A	5eshA-3cbtA: undetectable	5eshA-3cbtA: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OM2_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRY PSIN)	3cbt	PHOSPHATASE SC4828 (Streptomyces coelicolor)	5 / 9	VAL A 145 LEU A 59 ALA A 109 VAL A 49 ILE A 31	VAL A 145 ( 0.6A) LEU A 59 ( 0.6A) ALA A 109 (-0.0A) VAL A 49 ( 0.6A) ILE A 31 ( 0.6A)	1.08A	5om2A-3cbtA: undetectable 5om2B-3cbtA: undetectable	5om2A-3cbtA: 15.32 5om2B-3cbtA: 11.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OA1_B_ADNB2005_1","TRYPTOPHAN HALOGENASE","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",4,"GLY A 144;GLY A 143;VAL A  61;LEU A  59","GLY A 144 ( 0.0A);GLY A 143 ( 0.0A);VAL A  61 ( 0.6A);LEU A  59 ( 0.6A)","0.78A","2oa1B-3cbtA:undetectable","2oa1B-3cbtA:20.04"],["3K9F_H_LFXH0_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",4,"ARG A 110;GLY A 112;GLU A 197;GLU A 113","ARG A 110 (-0.6A);GLY A 112 ( 0.0A);GLU A 197 ( 0.6A);GLU A 113 (-0.5A)","1.12A","3k9fA-3cbtA:undetectable;3k9fB-3cbtA:undetectable;3k9fD-3cbtA:undetectable","3k9fA-3cbtA:17.64;3k9fB-3cbtA:17.64;3k9fD-3cbtA:18.32"],["3L8L_B_DVAB8_0","GRAMICIDIN D","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",3,"VAL A 156;VAL A 132;TRP A 130","VAL A 156 ( 0.6A);VAL A 132 ( 0.6A);TRP A 130 (-0.5A)","0.72A","3l8lA-3cbtA:undetectable;3l8lB-3cbtA:undetectable","3l8lA-3cbtA:7.55;3l8lB-3cbtA:8.81"],["4FU9_A_ACTA311_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",3,"GLN A 172;THR A  87;THR A  90","GLN A 172 ( 0.6A);THR A  87 ( 0.8A);THR A  90 ( 0.8A)","0.74A","4fu9A-3cbtA:undetectable","4fu9A-3cbtA:19.85"],["4FUF_A_ACTA310_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",3,"GLN A 172;THR A  87;THR A  90","GLN A 172 ( 0.6A);THR A  87 ( 0.8A);THR A  90 ( 0.8A)","0.72A","4fufA-3cbtA:undetectable","4fufA-3cbtA:19.85"],["5ESH_A_1YNA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",4,"TRP A 130;LEU A  58;PRO A 204;LEU A 138","TRP A 130 (-0.5A);LEU A  58 ( 0.6A);PRO A 204 (-1.1A);LEU A 138 ( 0.6A)","1.36A","5eshA-3cbtA:undetectable","5eshA-3cbtA:17.41"],["5OM2_B_DXTB501_1","ALPHA-1-ANTICHYMOTRYPSIN;ALPHA-1-ANTICHYMOTRYPSIN","3cbt","PHOSPHATASE SC4828","Streptomyces coelicolor",5,"VAL A 145;LEU A  59;ALA A 109;VAL A  49;ILE A  31","VAL A 145 ( 0.6A);LEU A  59 ( 0.6A);ALA A 109 (-0.0A);VAL A  49 ( 0.6A);ILE A  31 ( 0.6A)","1.08A","5om2A-3cbtA:undetectable;5om2B-3cbtA:undetectable","5om2A-3cbtA:15.32;5om2B-3cbtA:11.47"]]