SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3cbx DISHEVELLED-2
(Homo
sapiens) 		8 / 11 PHE A 277
LEU A 278
GLY A 279
ILE A 280
SER A 281
ILE A 282
VAL A 334
LEU A 337
 None
 0.59A 2kawA-3cbxA:
16.8		 2kawA-3cbxA:
88.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3cbx DISHEVELLED-2
(Homo
sapiens) 		9 / 11 PHE A 277
LEU A 278
GLY A 279
ILE A 280
SER A 281
VAL A 334
LEU A 337
ARG A 338
VAL A 341
 None
 0.68A 2kawA-3cbxA:
16.8		 2kawA-3cbxA:
88.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3cbx DISHEVELLED-2
(Homo
sapiens) 		5 / 12 ILE A 294
ILE A 347
VAL A 320
LEU A 349
ILE A 280
 None
 0.98A 5mueA-3cbxA:
undetectable		 5mueA-3cbxA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3cbx DISHEVELLED-2
(Homo
sapiens) 		5 / 12 ILE A 294
ILE A 347
VAL A 320
LEU A 349
ILE A 280
 None
 0.92A 5mugA-3cbxA:
undetectable		 5mugA-3cbxA:
16.74