SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ccy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		5 / 11 ARG A 136
GLN A 141
LEU A 142
ALA A 183
LEU A 131
 None
 1.26A 3jwqA-3ccyA:
undetectable
3jwqD-3ccyA:
undetectable		 3jwqA-3ccyA:
23.28
3jwqD-3ccyA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		3 / 3 HIS A 106
HIS A  66
ILE A  98
 None
 0.82A 3u52A-3ccyA:
undetectable
3u52C-3ccyA:
undetectable		 3u52A-3ccyA:
17.49
3u52C-3ccyA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		5 / 12 PHE A  95
CYH A  74
THR A 157
PHE A 161
VAL A  77
 None
 1.29A 3u9fJ-3ccyA:
undetectable
3u9fL-3ccyA:
undetectable		 3u9fJ-3ccyA:
20.60
3u9fL-3ccyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		5 / 12 PHE A  95
THR A 157
PHE A 161
LEU A  78
VAL A  77
 None
 1.36A 3u9fJ-3ccyA:
undetectable
3u9fL-3ccyA:
undetectable		 3u9fJ-3ccyA:
20.60
3u9fL-3ccyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		3 / 3 PRO A 179
ASP A 180
GLU A  97
 None
 0.79A 3v4tC-3ccyA:
undetectable		 3v4tC-3ccyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		4 / 7 TYR A 134
PHE A 161
ILE A 132
PHE A  95
 None
 0.99A 5esmA-3ccyA:
undetectable		 5esmA-3ccyA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		4 / 6 ALA A  57
LEU A  59
TYR A  29
SER A  54
 None
 1.07A 5phhA-3ccyA:
undetectable		 5phhA-3ccyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		4 / 7 LEU A 124
TYR A  29
GLU A  56
SER A  54
 None
 1.29A 5umwA-3ccyA:
undetectable
5umwF-3ccyA:
undetectable		 5umwA-3ccyA:
16.24
5umwF-3ccyA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		5 / 10 LEU A 139
ILE A 132
LEU A 131
LEU A  94
LEU A  78
 None
 1.26A 5y7pB-3ccyA:
undetectable		 5y7pB-3ccyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		5 / 10 LEU A 139
ILE A 132
LEU A 131
LEU A  94
LEU A  78
 None
 1.25A 5y7pD-3ccyA:
undetectable		 5y7pD-3ccyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR
(Bordetella
parapertussis) 		5 / 10 LEU A 139
ILE A 132
LEU A 131
LEU A  94
LEU A  78
 None
 1.24A 5y7pH-3ccyA:
undetectable		 5y7pH-3ccyA:
21.30