SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  12
LEU A  11
SER A   7
ILE A  56
LEU A 145
 None
 1.04A 2oipE-3cexA:
undetectable		 2oipE-3cexA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		4 / 5 THR A  10
ARG A  13
ALA A  14
ARG A  17
 None
 0.77A 2qhfA-3cexA:
undetectable		 2qhfA-3cexA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASN A  60
ALA A 152
LEU A 114
THR A  10
LEU A  11
 None
 1.07A 3p2kA-3cexA:
undetectable		 3p2kA-3cexA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASN A  60
ALA A 152
LEU A 114
THR A  10
LEU A  11
 None
 1.15A 3p2kB-3cexA:
undetectable		 3p2kB-3cexA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		3 / 3 LEU A 104
MET A  45
ASP A  78
 None
 0.82A 4j7xB-3cexA:
undetectable		 4j7xB-3cexA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  12
LEU A  11
SER A   7
ILE A  56
LEU A 145
 None
 1.01A 4ky8A-3cexA:
undetectable		 4ky8A-3cexA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  12
LEU A  11
SER A   7
ILE A  56
LEU A 145
 None
 1.03A 4ky8C-3cexA:
undetectable		 4ky8C-3cexA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  12
LEU A  11
SER A   7
ILE A  56
LEU A 145
 None
 1.02A 4ky8D-3cexA:
undetectable		 4ky8D-3cexA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASP A  12
LEU A  11
SER A   7
ILE A  56
LEU A 145
 None
 0.97A 4ky8E-3cexA:
undetectable		 4ky8E-3cexA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 9 LEU A 108
ALA A  14
GLN A 158
THR A  48
LEU A  52
 None
 1.40A 4ltwA-3cexA:
undetectable		 4ltwA-3cexA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3cex UNCHARACTERIZED
PROTEIN
(Enterococcus
faecalis) 		5 / 9 LEU A  11
ILE A  56
LEU A 114
VAL A 112
THR A 115
 None
 0.95A 4x3mB-3cexA:
undetectable		 4x3mB-3cexA:
21.79