SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A  69
PHE A  79
GLY A 118
ARG A 126
 None
 1.17A 1gsfA-3cezA:
undetectable		 1gsfA-3cezA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A  69
PHE A  79
GLY A 118
ARG A 126
 None
 1.18A 1gsfB-3cezA:
undetectable		 1gsfB-3cezA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		4 / 8 TYR A  69
PHE A  79
GLY A 118
ARG A 126
 None
 1.18A 1gsfD-3cezA:
undetectable		 1gsfD-3cezA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		5 / 10 CYH A  58
VAL A  57
CYH A 104
GLY A 108
ALA A 109
 ZN  A 201 (-2.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-2.3A)
None
ZN  A 201 ( 4.4A)
 1.22A 3ucjA-3cezA:
undetectable		 3ucjA-3cezA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		5 / 10 CYH A  55
VAL A  57
CYH A 104
GLY A 108
ALA A 109
 ZN  A 201 (-2.2A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-2.3A)
None
ZN  A 201 ( 4.4A)
 1.23A 3ucjB-3cezA:
undetectable		 3ucjB-3cezA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		5 / 10 CYH A  58
VAL A  57
CYH A 104
GLY A 108
ALA A 109
 ZN  A 201 (-2.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-2.3A)
None
ZN  A 201 ( 4.4A)
 1.21A 3ucjB-3cezA:
undetectable		 3ucjB-3cezA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cez METHIONINE-R-SULFOXI
DE REDUCTASE
(Burkholderia
pseudomallei) 		4 / 4 LEU A 111
TYR A  69
PRO A  81
ILE A  82
 None
 1.19A 5esgA-3cezA:
undetectable		 5esgA-3cezA:
14.15