SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cf4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 LEU A 654
LEU A 696
LEU A 198
GLY A 642
 None
 0.85A 1a4lC-3cf4A:
undetectable		 1a4lC-3cf4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 LYS A 637
ILE A 281
ASP A 320
GLY A 249
ALA A 253
 WCC  A 811 ( 3.6A)
None
None
None
None
 1.09A 1axwA-3cf4A:
undetectable		 1axwA-3cf4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 ILE A 546
ALA A 582
ILE A 584
PHE A 576
ILE A 517
 None
 1.10A 1dg5A-3cf4A:
undetectable		 1dg5A-3cf4A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ALA G 127
LEU G 125
THR A  70
VAL A  68
 ACY  A 821 (-3.6A)
PEG  G 173 ( 4.0A)
None
ACY  A 821 ( 4.3A)
 0.62A 1dvxB-3cf4G:
undetectable		 1dvxB-3cf4G:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 VAL A 298
GLY A 275
LEU A 283
GLU A 288
 None
None
None
GOL  A 826 (-3.7A)
 0.95A 1fduD-3cf4A:
6.8		 1fduD-3cf4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 650
ALA A 597
LEU A 609
ALA A 605
ILE A 620
 None
 1.18A 1g5yB-3cf4A:
undetectable		 1g5yB-3cf4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 LEU A 388
LEU A 245
TYR A 261
LEU A 381
 None
 0.99A 1kt3A-3cf4A:
undetectable		 1kt3A-3cf4A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ALA A 500
ARG A 494
GLN A 577
GLU A 227
ARG A 291
 None
 1.42A 1lf9B-3cf4A:
0.0		 1lf9B-3cf4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 ASP A 239
ASP A 269
LYS A 297
 None
 1.17A 1lquB-3cf4A:
2.5		 1lquB-3cf4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 PRO A 707
MET A 708
ALA A 712
GLU A 693
 ACY  A 818 ( 4.7A)
None
None
None
 1.42A 1qhyA-3cf4A:
3.9		 1qhyA-3cf4A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 GLU A 771
TRP A 746
LYS G  59
 None
 1.41A 1qu2A-3cf4A:
undetectable		 1qu2A-3cf4A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 VAL A 216
VAL A 252
ARG A 494
CYH A 587
 None
None
None
WCC  A 811 (-2.2A)
 1.04A 1t46A-3cf4A:
undetectable		 1t46A-3cf4A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 MET G  89
ALA G  87
TYR G  84
ILE G  85
 ACY  G 171 ( 4.4A)
None
ACY  A 818 ( 4.9A)
None
 1.15A 1upfC-3cf4G:
3.1		 1upfC-3cf4G:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ILE A 129
LEU A 125
THR A 139
LEU A 138
 None
 0.93A 1v55A-3cf4A:
1.4
1v55J-3cf4A:
undetectable		 1v55A-3cf4A:
21.47
1v55J-3cf4A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 TYR A 569
ALA A 596
GLY A 585
GLY A 495
ILE A 281
 None
 1.13A 1x1aA-3cf4A:
2.5		 1x1aA-3cf4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 MET A 168
ASN A 251
GLN A 322
 None
 0.82A 1xoqB-3cf4A:
undetectable		 1xoqB-3cf4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 PRO A 692
LEU A 621
GLY A 617
LEU A 695
 None
 0.75A 1ya4A-3cf4A:
2.1		 1ya4A-3cf4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 PRO A 692
LEU A 621
GLY A 617
LEU A 695
 None
 0.82A 1ya4B-3cf4A:
undetectable		 1ya4B-3cf4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 LYS A 196
ASP A 192
GLU A 190
ARG A 104
 None
None
None
SF4  A 810 (-3.6A)
 1.50A 1yc2A-3cf4A:
5.1
1yc2B-3cf4A:
5.6
1yc2E-3cf4A:
5.5		 1yc2A-3cf4A:
17.10
1yc2B-3cf4A:
17.10
1yc2E-3cf4A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 SER A 717
ASP A 679
CYH A 804
 GOL  A 825 ( 4.9A)
None
None
 1.14A 2br4E-3cf4A:
3.4		 2br4E-3cf4A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 ALA G  21
PHE G 151
ALA G  27
LEU G 166
 None
 0.91A 2bxmA-3cf4G:
undetectable		 2bxmA-3cf4G:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 4 LEU G 166
ILE G 112
ILE G  63
ALA G  61
 None
 0.84A 2i30A-3cf4G:
undetectable		 2i30A-3cf4G:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 LEU A 695
PRO A 716
VAL A 624
GLY A 625
 None
 1.01A 2qd5B-3cf4A:
2.7		 2qd5B-3cf4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 LEU A 756
PRO A 757
LEU A 764
 None
 0.42A 2qd5B-3cf4A:
2.7		 2qd5B-3cf4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 SER A 720
THR A 513
PHE A 604
 None
 0.62A 2x91A-3cf4A:
undetectable		 2x91A-3cf4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 SER A 658
PRO A 524
GLY A 632
TRP A 631
 None
WCC  A 811 (-4.8A)
None
None
 1.39A 2y7pA-3cf4A:
3.6		 2y7pA-3cf4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ILE A 129
LEU A 125
THR A 139
LEU A 138
 None
 0.96A 3ag3A-3cf4A:
1.8
3ag3J-3cf4A:
undetectable		 3ag3A-3cf4A:
21.47
3ag3J-3cf4A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 VAL A 247
GLY A 312
ARG A 310
LEU A 404
 None
 1.10A 3bjwE-3cf4A:
undetectable		 3bjwE-3cf4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ALA G 127
LEU G 125
THR A  70
VAL A  68
 ACY  A 821 (-3.6A)
PEG  G 173 ( 4.0A)
None
ACY  A 821 ( 4.3A)
 0.64A 3d2tA-3cf4G:
undetectable		 3d2tA-3cf4G:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 ALA G 127
LEU G 125
THR A  70
VAL A  68
 ACY  A 821 (-3.6A)
PEG  G 173 ( 4.0A)
None
ACY  A 821 ( 4.3A)
 0.60A 3d2tB-3cf4G:
undetectable		 3d2tB-3cf4G:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		6 / 11 THR A 549
ALA A 519
GLY A 553
GLY A 522
ILE A 518
VAL A 533
 None
None
None
WCC  A 811 (-3.6A)
None
None
 1.48A 3dcmX-3cf4A:
undetectable		 3dcmX-3cf4A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 GLY A 574
THR A 549
GLU A 227
GLU A 288
 None
None
None
GOL  A 826 (-3.7A)
 0.74A 3fpjA-3cf4A:
undetectable		 3fpjA-3cf4A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 GLY A 585
HIS A 120
ILE A 593
LYS A 637
HIS A 250
 None
None
None
WCC  A 811 ( 3.6A)
FE  A 808 ( 3.2A)
 0.98A 3g9eA-3cf4A:
undetectable		 3g9eA-3cf4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 SER A 640
GLY A 113
SER A 635
 None
None
WCC  A 811 (-3.2A)
 0.68A 3loqA-3cf4A:
2.3		 3loqA-3cf4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 9 ALA A 436
ASP A 432
ILE A 431
ILE A 469
ILE A 451
 None
None
SF4  A 813 ( 4.3A)
SF4  A 814 ( 4.4A)
None
 0.87A 3nu4B-3cf4A:
undetectable		 3nu4B-3cf4A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ALA G 127
LEU G 125
THR A  70
VAL A  68
 ACY  A 821 (-3.6A)
PEG  G 173 ( 4.0A)
None
ACY  A 821 ( 4.3A)
 0.64A 3ozkB-3cf4G:
undetectable		 3ozkB-3cf4G:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 SER G  58
GLY G  42
GLU A 704
GLU A 700
 None
 1.45A 3raeB-3cf4G:
undetectable
3raeD-3cf4G:
2.7		 3raeB-3cf4G:
16.94
3raeD-3cf4G:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 584
GLY A 493
GLY A 585
SER A 586
ASP A 282
 None
 0.99A 3uboA-3cf4A:
3.9		 3uboA-3cf4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 HIS A 120
VAL A 255
ASP A 212
GLN A 215
 None
 1.04A 3uy4A-3cf4A:
2.8		 3uy4A-3cf4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE G 111
LEU G  46
ILE G  63
ILE G  57
LEU G 163
 None
 1.03A 3w67B-3cf4G:
undetectable		 3w67B-3cf4G:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 PHE A 244
LEU A 276
GLY A 300
ILE A 238
 None
 0.75A 3wrkA-3cf4A:
undetectable		 3wrkA-3cf4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 ARG A 571
PHE A 572
PRO A 573
 ACY  A 817 (-4.0A)
ACY  A 817 ( 4.4A)
None
 0.72A 3zoaB-3cf4A:
undetectable		 3zoaB-3cf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 TYR A 378
ASP A 320
ASP A 282
 None
 0.85A 4a6eA-3cf4A:
2.6		 4a6eA-3cf4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 GLY A 493
ILE A 584
VAL A 216
SER A 589
 None
 0.94A 4d33A-3cf4A:
undetectable		 4d33A-3cf4A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 MET A 490
GLY A 495
SER A 589
ASP A 212
VAL A 216
 None
 1.04A 4d9hA-3cf4A:
undetectable		 4d9hA-3cf4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 9 MET A 490
GLY A 495
SER A 589
ASP A 212
VAL A 216
 None
 1.04A 4da6A-3cf4A:
undetectable		 4da6A-3cf4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 10 MET A 490
GLY A 495
ALA A 228
SER A 589
VAL A 216
 None
 1.13A 4da7A-3cf4A:
undetectable		 4da7A-3cf4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 ASN G  86
LEU G 102
PHE G  92
 None
 0.74A 4dajB-3cf4G:
undetectable		 4dajB-3cf4G:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 MET A 490
GLY A 495
SER A 589
ASP A 212
VAL A 216
 None
 1.09A 4danA-3cf4A:
undetectable		 4danA-3cf4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 LYS A 637
ILE A 281
ASP A 320
GLY A 249
ALA A 253
 WCC  A 811 ( 3.6A)
None
None
None
None
 1.10A 4fogD-3cf4A:
undetectable		 4fogD-3cf4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 SER A 202
ILE A 647
ASP A 618
GLY A 617
PHE A 648
 None
None
GOL  A 825 ( 4.8A)
None
None
 1.33A 4foxE-3cf4A:
undetectable		 4foxE-3cf4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 SER A 202
ILE A 647
ASP A 618
GLY A 617
PHE A 648
 None
None
GOL  A 825 ( 4.8A)
None
None
 1.26A 4foxH-3cf4A:
undetectable		 4foxH-3cf4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 ILE A 517
ALA A 597
ALA A 596
ILE A 584
VAL A 548
 None
 0.99A 4h1nA-3cf4A:
0.1		 4h1nA-3cf4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 ALA G 127
LEU G 125
THR A  70
VAL A  68
 ACY  A 821 (-3.6A)
PEG  G 173 ( 4.0A)
None
ACY  A 821 ( 4.3A)
 0.62A 4ik7B-3cf4G:
undetectable		 4ik7B-3cf4G:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 546
ALA A 582
ILE A 584
PHE A 576
ILE A 517
 None
 1.03A 4km0B-3cf4A:
undetectable		 4km0B-3cf4A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 ALA G  45
PHE G 151
THR G   4
VAL G   2
 ACY  A 819 ( 4.3A)
None
None
None
 0.95A 4ltwA-3cf4G:
undetectable		 4ltwA-3cf4G:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 8 ILE A 616
GLU A 615
ILE A 650
LEU A 621
 None
 0.91A 4mj8A-3cf4A:
undetectable		 4mj8A-3cf4A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ALA A 228
GLY A 585
GLY A 495
THR A 550
ILE A 520
 None
 1.13A 4n48B-3cf4A:
2.0		 4n48B-3cf4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 616
ILE A 620
GLY A 595
ALA A 596
VAL A 624
 None
 0.96A 4nkvA-3cf4A:
undetectable		 4nkvA-3cf4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 616
ILE A 620
GLY A 595
ALA A 596
VAL A 624
 None
 0.95A 4nkvB-3cf4A:
undetectable		 4nkvB-3cf4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 616
ILE A 620
GLY A 595
ALA A 596
VAL A 624
 None
 0.98A 4nkvC-3cf4A:
undetectable		 4nkvC-3cf4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ILE A 616
ILE A 620
GLY A 595
ALA A 596
VAL A 624
 None
 0.97A 4nkvD-3cf4A:
undetectable		 4nkvD-3cf4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ASP A 225
SER A 589
GLY A 585
GLN A 215
ASP A 212
 None
 1.35A 4pevA-3cf4A:
4.0		 4pevA-3cf4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 LEU A 388
LEU A 384
LYS A 366
LEU A 365
 None
 0.78A 4wg0L-3cf4A:
undetectable
4wg0M-3cf4A:
undetectable		 4wg0L-3cf4A:
2.44
4wg0M-3cf4A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 LEU A 765
LEU A 768
GLU A 769
ILE A 783
 None
 0.94A 4ww7A-3cf4A:
undetectable		 4ww7A-3cf4A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 9 LEU A 245
ILE A 340
MET A 375
LEU A 384
VAL A 386
 None
 1.04A 4x3mB-3cf4A:
3.2		 4x3mB-3cf4A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		5 / 9 TYR G 108
ILE G  63
THR G  68
LEU G  90
LEU G  94
 None
 1.28A 4ze0A-3cf4G:
undetectable		 4ze0A-3cf4G:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 SER A 200
ARG A 662
GLY A 103
THR A  70
 None
 1.20A 5btiA-3cf4A:
undetectable
5btiB-3cf4A:
undetectable		 5btiA-3cf4A:
22.01
5btiB-3cf4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 SER A 200
ARG A 662
GLY A 103
THR A  70
 None
 1.20A 5btiC-3cf4A:
undetectable
5btiD-3cf4A:
undetectable		 5btiC-3cf4A:
22.01
5btiD-3cf4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 ASN G  86
LEU G 102
PHE G  92
 None
 0.69A 5dsgA-3cf4G:
undetectable		 5dsgA-3cf4G:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ALA A 582
GLU A 501
GLY A 574
GLY A 579
 None
 0.87A 5e26A-3cf4A:
undetectable
5e26B-3cf4A:
1.1		 5e26A-3cf4A:
19.46
5e26B-3cf4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 GLU A 501
GLY A 574
GLY A 579
ALA A 582
 None
 0.88A 5e26C-3cf4A:
undetectable
5e26D-3cf4A:
undetectable		 5e26C-3cf4A:
19.46
5e26D-3cf4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ASP A 618
ASP A 718
PRO A 716
GLY A 625
THR A 514
 GOL  A 825 ( 4.8A)
None
None
None
None
 1.25A 5hfjH-3cf4A:
2.1		 5hfjH-3cf4A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 LEU A 613
GLY A 155
ILE A 152
VAL A 206
PRO A  48
 None
 1.11A 5hjiA-3cf4A:
2.5		 5hjiA-3cf4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 GLY G  69
ALA G  87
PHE G 119
TYR G 120
VAL G 124
 None
 1.24A 5hw4B-3cf4G:
3.7		 5hw4B-3cf4G:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 ILE A 517
GLY A 644
ASN A 646
ILE A 593
 None
 0.91A 5j4nB-3cf4A:
undetectable		 5j4nB-3cf4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 TYR A 569
THR A 550
THR A 549
ALA A 554
GLY A 495
 None
 1.12A 5lf7V-3cf4A:
2.7
5lf7b-3cf4A:
undetectable		 5lf7V-3cf4A:
15.08
5lf7b-3cf4A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 TYR A 569
THR A 550
THR A 549
ALA A 554
GLY A 495
 None
 1.12A 5lf7H-3cf4A:
2.7
5lf7N-3cf4A:
undetectable		 5lf7H-3cf4A:
15.08
5lf7N-3cf4A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 ALA G  66
LEU G  38
ILE G 112
SER G  58
ILE G  85
 None
 1.08A 5m24A-3cf4G:
undetectable		 5m24A-3cf4G:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 VAL A 588
ASP A 212
HIS A 120
ARG A 285
LEU A 283
 None
 1.37A 5m50B-3cf4A:
3.0		 5m50B-3cf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 SER A 153
THR A 114
ILE A 111
LEU A 175
 None
 0.97A 5te8A-3cf4A:
undetectable		 5te8A-3cf4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 SER G  58
ALA G  82
ILE G  85
LEU G 102
 None
 0.99A 5te8A-3cf4G:
undetectable		 5te8A-3cf4G:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 GLY A 506
ARG A 503
MET A 511
GLN A 796
 None
None
None
ACY  A 824 ( 3.2A)
 1.42A 5ubbA-3cf4A:
1.6		 5ubbA-3cf4A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 TYR A 286
ALA A 218
TYR A 219
 None
 0.86A 5uunB-3cf4A:
undetectable		 5uunB-3cf4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 GLY A 642
VAL A 171
LEU A 175
PHE A 106
ARG A 663
 None
 1.17A 5vooA-3cf4A:
undetectable		 5vooA-3cf4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 GLY A 642
VAL A 171
LEU A 175
PHE A 106
ARG A 663
 None
 1.18A 5vooC-3cf4A:
undetectable		 5vooC-3cf4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		6 / 12 GLY A 300
GLY A 558
GLY A 234
THR A 567
ASP A 556
ILE A 557
 None
 1.48A 5wz2C-3cf4A:
2.0		 5wz2C-3cf4A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		6 / 12 GLY A 300
GLY A 558
GLY A 488
GLY A 234
THR A 567
ILE A 557
 None
 1.48A 5wz2C-3cf4A:
2.0		 5wz2C-3cf4A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 HIS A 117
ALA A 638
SER A 640
GLY A 113
 CMO  A 812 (-4.5A)
None
None
None
 1.10A 5yodB-3cf4A:
undetectable		 5yodB-3cf4A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 HIS A 117
ALA A 638
SER A 640
GLY A 113
 CMO  A 812 (-4.5A)
None
None
None
 1.10A 5yodD-3cf4A:
undetectable		 5yodD-3cf4A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		4 / 7 THR A 454
ARG G 141
HIS G 159
ASP A 432
 None
GOL  G 172 ( 4.4A)
None
None
 1.36A 6mn4E-3cf4A:
undetectable		 6mn4E-3cf4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 THR A 154
LEU A  46
THR A 147
LEU A 613
 None
 1.17A 6mvxA-3cf4A:
undetectable
6mvxB-3cf4A:
3.1
6mvxC-3cf4A:
3.2		 6mvxA-3cf4A:
16.13
6mvxB-3cf4A:
16.13
6mvxC-3cf4A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT
(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		5 / 12 VAL A 653
HIS A 734
TYR G  84
ILE G  85
ASN G  86
 None
ACY  A 818 (-3.8A)
ACY  A 818 ( 4.9A)
None
None
 1.49A 6mxtA-3cf4A:
undetectable		 6mxtA-3cf4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 ILE A 129
LEU A 125
THR A 139
LEU A 138
 None
 0.95A 6nmpA-3cf4A:
undetectable
6nmpJ-3cf4A:
undetectable		 6nmpA-3cf4A:
21.47
6nmpJ-3cf4A:
7.13