SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		5 / 12 MET L  41
CYH L  26
ILE A 121
PHE L  24
LEU L  51
 NRQ  A  65 ( 3.5A)
None
None
None
None
 1.42A 1m2zD-3cfhL:
undetectable		 1m2zD-3cfhL:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		4 / 7 GLU A 145
GLU A 195
ILE A  70
LEU A 154
 NRQ  A  65 ( 3.3A)
None
None
None
 1.25A 1q0yH-3cfhA:
undetectable
1q0yL-3cfhA:
undetectable		 1q0yH-3cfhA:
22.64
1q0yL-3cfhA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata;
Anemonia
sulcata) 		5 / 12 PHE L  11
ALA A 216
LEU A 110
GLY L  37
LEU L   5
 None
None
CME  A 114 ( 4.6A)
None
None
 1.20A 1qabF-3cfhL:
undetectable		 1qabF-3cfhL:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB201_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		5 / 9 GLU A 195
GLU A 145
MET A 160
LEU A 159
GLU A 214
 None
NRQ  A  65 ( 3.3A)
NRQ  A  65 ( 3.6A)
None
NRQ  A  65 ( 3.1A)
 1.29A 1wrlA-3cfhA:
undetectable
1wrlB-3cfhA:
undetectable		 1wrlA-3cfhA:
18.63
1wrlB-3cfhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		5 / 10 GLU A 195
GLU A 145
MET A 160
LEU A 159
GLU A 214
 None
NRQ  A  65 ( 3.3A)
NRQ  A  65 ( 3.6A)
None
NRQ  A  65 ( 3.1A)
 1.42A 1wrlE-3cfhA:
undetectable
1wrlF-3cfhA:
undetectable		 1wrlE-3cfhA:
18.63
1wrlF-3cfhA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		5 / 12 ALA A 137
ASP L  56
GLY A 139
GLY A 138
ALA L  54
 None
 1.15A 2c49A-3cfhA:
undetectable		 2c49A-3cfhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata;
Anemonia
sulcata) 		4 / 5 GLY L  37
ALA A 216
PHE A  69
GLU A 214
 None
None
None
NRQ  A  65 ( 3.1A)
 0.89A 4m93B-3cfhL:
undetectable
4m93C-3cfhL:
undetectable		 4m93B-3cfhL:
15.42
4m93C-3cfhL:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		4 / 7 ASN L  33
PRO L  34
PHE A  69
TYR A 213
 None
 1.28A 4v2zA-3cfhL:
undetectable		 4v2zA-3cfhL:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		4 / 7 ASN L  33
PRO L  34
PHE A  69
TYR A 213
 None
 1.27A 4v30A-3cfhL:
undetectable		 4v30A-3cfhL:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		4 / 7 ASN L  33
PRO L  34
PHE A  69
TYR A 213
 None
 1.29A 5amjA-3cfhL:
undetectable		 5amjA-3cfhL:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		4 / 7 ASN L  33
PRO L  34
PHE A  69
TYR A 213
 None
 1.29A 5amjB-3cfhL:
undetectable		 5amjB-3cfhL:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata;
Anemonia
sulcata) 		4 / 7 ASN L  33
PRO L  34
PHE A  69
TYR A 213
 None
 1.29A 5oh3B-3cfhL:
undetectable		 5oh3B-3cfhL:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		4 / 5 TYR A  72
GLU A 195
TYR A 213
HIS A 197
 None
None
None
NRQ  A  65 ( 3.8A)
 1.29A 6ep4A-3cfhA:
undetectable		 6ep4A-3cfhA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3cfh GFP-LIKE
PHOTOSWITCHABLE
FLUORESCENT PROTEIN
(Anemonia
sulcata) 		5 / 11 ILE A  70
TYR A 178
LEU A 154
GLY A 156
SER A 158
 None
None
None
None
NRQ  A  65 ( 2.0A)
 1.19A 6ieyA-3cfhA:
undetectable
6ieyB-3cfhA:
undetectable		 6ieyA-3cfhA:
19.38
6ieyB-3cfhA:
19.38