SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cfx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 8 GLU A 227
GLN A 329
HIS A 252
SER A 231
 WO4  A 701 (-2.5A)
None
None
None
 1.33A 1nx9A-3cfxA:
undetectable		 1nx9A-3cfxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 8 GLU A 227
GLN A 329
HIS A 252
SER A 231
 WO4  A 701 (-2.5A)
None
None
None
 1.32A 1nx9B-3cfxA:
undetectable		 1nx9B-3cfxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 8 GLU A 227
GLN A 329
HIS A 252
SER A 231
 WO4  A 701 (-2.5A)
None
None
None
 1.32A 1nx9C-3cfxA:
undetectable		 1nx9C-3cfxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 8 GLU A 227
GLN A 329
HIS A 252
SER A 231
 WO4  A 701 (-2.5A)
None
None
None
 1.32A 1nx9D-3cfxA:
undetectable		 1nx9D-3cfxA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 11 GLN A 172
LEU A 189
VAL A 277
ALA A 204
LEU A 205
 MG  A 703 ( 4.5A)
None
None
None
None
 1.36A 2c12F-3cfxA:
undetectable		 2c12F-3cfxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A 284
HIS A 207
VAL A 277
ASN A 159
GLY A 164
 None
 1.08A 2vmyB-3cfxA:
undetectable		 2vmyB-3cfxA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 8 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.97A 3asoC-3cfxA:
undetectable
3asoJ-3cfxA:
undetectable		 3asoC-3cfxA:
20.43
3asoJ-3cfxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A  77
ASP A 161
PRO A 162
ALA A 163
ALA A  75
 WO4  A 701 (-3.4A)
WO4  A 701 (-2.8A)
WO4  A 701 (-3.5A)
WO4  A 701 (-3.4A)
None
 0.85A 3jb1A-3cfxA:
undetectable		 3jb1A-3cfxA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 7 ILE A 239
LEU A 230
SER A 167
VAL A 208
 None
 0.97A 3r9vA-3cfxA:
undetectable
3r9vB-3cfxA:
undetectable		 3r9vA-3cfxA:
21.78
3r9vB-3cfxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A  49
ASP A 161
SER A  81
ALA A  79
SER A 105
 WO4  A 701 (-3.2A)
WO4  A 701 (-2.8A)
None
None
None
 1.16A 3sueD-3cfxA:
undetectable		 3sueD-3cfxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 LEU A  95
LEU A  58
SER A  81
PHE A 118
GLY A 320
 None
 0.85A 4dm8B-3cfxA:
undetectable		 4dm8B-3cfxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 7 GLY A 193
ILE A 221
LEU A 223
PHE A 155
 None
None
GOL  A 901 (-4.0A)
None
 0.70A 4ejjD-3cfxA:
undetectable		 4ejjD-3cfxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 GLY A 134
PHE A 254
ASN A 138
VAL A 257
LEU A 125
 None
 1.07A 4fr0A-3cfxA:
undetectable		 4fr0A-3cfxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 11 SER A 156
GLY A 164
ARG A 166
ALA A  98
ALA A  60
 None
None
None
WO4  A 701 (-3.5A)
None
 1.12A 4l6v1-3cfxA:
undetectable
4l6v6-3cfxA:
undetectable		 4l6v1-3cfxA:
18.63
4l6v6-3cfxA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 10 TYR A 165
LEU A 102
LEU A  51
ALA A  48
GLY A 295
 None
None
None
WO4  A 701 (-3.2A)
None
 1.26A 4rn6A-3cfxA:
undetectable		 4rn6A-3cfxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 8 TRP A 142
LEU A 146
MET A 188
THR A 171
 None
 1.04A 5hs6A-3cfxA:
undetectable		 5hs6A-3cfxA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 LEU A 173
ALA A 174
TYR A 143
ALA A 163
TYR A 245
 None
None
None
WO4  A 701 (-3.4A)
WO4  A 701 (-4.3A)
 1.08A 5n5dB-3cfxA:
undetectable		 5n5dB-3cfxA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 5 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.90A 5x19C-3cfxA:
undetectable
5x19J-3cfxA:
undetectable		 5x19C-3cfxA:
20.43
5x19J-3cfxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		3 / 3 LYS A 276
ASN A 273
SER A 176
 None
 0.99A 5yw0A-3cfxA:
undetectable		 5yw0A-3cfxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 VAL A  53
PHE A 118
PHE A 311
PHE A 324
HIS A  47
 None
 1.12A 6ap6A-3cfxA:
undetectable		 6ap6A-3cfxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 VAL A  53
PHE A 118
PHE A 311
PHE A 324
HIS A  47
 None
 1.13A 6ap6B-3cfxA:
undetectable		 6ap6B-3cfxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		4 / 6 SER A  97
TYR A 294
ASP A 161
GLU A 227
 None
None
WO4  A 701 (-2.8A)
WO4  A 701 (-2.5A)
 1.28A 6djzA-3cfxA:
undetectable		 6djzA-3cfxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 3cfx UPF0100 PROTEIN
MA_0280
(Methanosarcina
acetivorans) 		5 / 12 LEU A  58
ALA A 119
PHE A 118
LEU A 315
ARG A  73
 None
 1.18A 6ew0G-3cfxA:
undetectable		 6ew0G-3cfxA:
17.79