SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
 None
 1.13A 2vcvD-3cfzA:
undetectable		 2vcvD-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
 None
 1.15A 2vcvE-3cfzA:
undetectable		 2vcvE-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
 None
 1.13A 2vcvH-3cfzA:
undetectable		 2vcvH-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 PRO A  51
LEU A 317
LEU A  48
ALA A  93
PHE A 115
 None
 1.18A 2vcvI-3cfzA:
undetectable		 2vcvI-3cfzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 126
THR A 222
GLU A 229
 None
 0.80A 2zifB-3cfzA:
undetectable		 2zifB-3cfzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A  76
ASN A 156
GLN A 165
ILE A 282
 None
 1.01A 4iilA-3cfzA:
3.3		 4iilA-3cfzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A  76
ASN A 156
GLN A 165
MET A 103
 None
 0.92A 4iilA-3cfzA:
3.3		 4iilA-3cfzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 273
ASP A  96
ARG A 163
ILE A 287
 None
 1.43A 4mwrA-3cfzA:
undetectable		 4mwrA-3cfzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  90
HIS A 299
LYS A 300
 None
 0.83A 4qzuD-3cfzA:
undetectable		 4qzuD-3cfzA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 10 TYR A 162
LEU A  99
LEU A  48
ALA A  45
GLY A 290
 None
None
None
WO4  A 701 (-3.0A)
None
 1.21A 4rn6A-3cfzA:
undetectable		 4rn6A-3cfzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		3 / 3 ASN A 320
PHE A  52
TYR A 289
 None
 0.89A 4u15A-3cfzA:
undetectable		 4u15A-3cfzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 SER A  75
GLN A 165
PHE A 237
ILE A 238
ALA A 123
 WO4  A 701 (-2.1A)
None
None
None
None
 1.36A 5entC-3cfzA:
undetectable		 5entC-3cfzA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 TYR A 181
GLN A 165
ILE A 202
VAL A 204
LEU A 208
 None
 1.14A 5fxfA-3cfzA:
0.0		 5fxfA-3cfzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 9 VAL A 193
TYR A 181
GLN A 165
ILE A 202
LEU A 208
 None
 1.19A 5fxfA-3cfzA:
0.0		 5fxfA-3cfzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 10 TYR A 181
GLN A 165
ILE A 202
VAL A 204
LEU A 208
 None
 1.14A 5fxfB-3cfzA:
1.5		 5fxfB-3cfzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 193
TYR A 181
GLN A 165
ILE A 202
LEU A 208
 None
 1.18A 5fxfB-3cfzA:
1.5		 5fxfB-3cfzA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		4 / 4 VAL A 121
ASN A 258
LYS A 240
TYR A 239
 None
None
None
WO4  A 701 (-4.2A)
 1.29A 5yf0A-3cfzA:
0.1		 5yf0A-3cfzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_ACTB502_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		4 / 4 VAL A 121
ASN A 258
LYS A 240
TYR A 239
 None
None
None
WO4  A 701 (-4.2A)
 1.26A 5yf0B-3cfzA:
0.5		 5yf0B-3cfzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		4 / 6 SER A  94
TYR A 289
ASP A 158
GLU A 221
 None
None
WO4  A 701 (-2.7A)
WO4  A 701 (-2.6A)
 1.30A 6djzA-3cfzA:
undetectable		 6djzA-3cfzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3cfz UPF0100 PROTEIN
MJ1186
(Methanocaldococc
us
jannaschii) 		3 / 3 TRP A 139
ILE A 257
GLU A 119
 None
 0.82A 6hcxA-3cfzA:
undetectable		 6hcxA-3cfzA:
11.30