SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 12 GLU A 119
VAL A 121
ILE A 122
ILE A 144
PHE A 124
 None
 1.16A 1c9hA-3cg1A:
undetectable		 1c9hA-3cg1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 12 LEU A 221
LEU A 224
VAL A 225
SER A 227
LEU A 145
 None
 1.12A 1db1A-3cg1A:
undetectable		 1db1A-3cg1A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 5 PHE A 115
GLY A  93
SER A  42
PHE A  47
 None
None
WO4  A 701 (-3.0A)
None
 1.38A 1icvA-3cg1A:
undetectable
1icvB-3cg1A:
undetectable		 1icvA-3cg1A:
21.43
1icvB-3cg1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		3 / 3 LEU A 221
LEU A 224
SER A 229
 None
 0.69A 1tlmA-3cg1A:
undetectable		 1tlmA-3cg1A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 8 LYS A  81
VAL A  82
TYR A 108
LEU A 291
 None
 0.92A 1z2bB-3cg1A:
undetectable		 1z2bB-3cg1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 12 GLN A 242
GLY A  41
LEU A  43
LEU A 221
SER A 155
 None
WO4  A 701 (-3.3A)
None
None
None
 1.36A 2nv4B-3cg1A:
undetectable		 2nv4B-3cg1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 10 ALA A 201
ILE A 192
ILE A 212
ILE A 214
ASP A 156
 None
 1.30A 4dtaA-3cg1A:
undetectable		 4dtaA-3cg1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 6 LEU A 145
TYR A 142
LEU A 185
GLU A 184
 None
 1.20A 4f3tA-3cg1A:
2.2		 4f3tA-3cg1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 10 TYR A 164
LEU A  99
LEU A  43
ALA A  40
GLY A 287
 None
None
None
WO4  A 701 (-3.1A)
None
 1.26A 4rn6A-3cg1A:
undetectable		 4rn6A-3cg1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		3 / 3 ASN A 319
PHE A  47
TYR A 286
 None
 0.75A 4u15A-3cg1A:
undetectable		 4u15A-3cg1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 12 ASN A 137
GLU A 143
ILE A 144
ASP A 149
SER A 136
 None
 1.19A 4uroD-3cg1A:
undetectable		 4uroD-3cg1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 6 PHE A 115
GLY A  93
TYR A 286
ALA A  40
 None
None
None
WO4  A 701 (-3.1A)
 1.11A 4yshB-3cg1A:
undetectable		 4yshB-3cg1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 6 ALA A  78
SER A  42
ASP A 160
PRO A 161
 None
WO4  A 701 (-3.0A)
WO4  A 701 (-2.7A)
WO4  A 701 (-3.7A)
 1.16A 5c6pA-3cg1A:
undetectable		 5c6pA-3cg1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 12 PRO A  46
LEU A  43
GLU A 317
PHE A 316
GLY A 312
 None
 1.31A 5il1A-3cg1A:
undetectable		 5il1A-3cg1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 6 LEU A 167
SER A 166
ILE A 186
PHE A 182
 None
 0.98A 5jw1A-3cg1A:
undetectable		 5jw1A-3cg1A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 8 ILE A 144
LEU A 145
LEU A 185
MET A 134
 None
 0.86A 5u4sB-3cg1A:
undetectable		 5u4sB-3cg1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 4 VAL A 121
ASN A 255
LYS A 237
TYR A 236
 None
None
None
WO4  A 701 (-4.4A)
 1.28A 5yf0A-3cg1A:
0.6		 5yf0A-3cg1A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_ACTB502_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		4 / 4 VAL A 121
ASN A 255
LYS A 237
TYR A 236
 None
None
None
WO4  A 701 (-4.4A)
 1.25A 5yf0B-3cg1A:
0.8		 5yf0B-3cg1A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 11 ILE A 279
PRO A 161
LEU A 272
SER A 274
ASP A  84
 None
WO4  A 701 (-3.7A)
None
None
None
 1.42A 6dlzA-3cg1A:
2.3
6dlzD-3cg1A:
9.2		 6dlzA-3cg1A:
14.53
6dlzD-3cg1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 11 ILE A 279
PRO A 161
LEU A 272
SER A 274
ASP A  84
 None
WO4  A 701 (-3.7A)
None
None
None
 1.42A 6dm1A-3cg1A:
2.1
6dm1D-3cg1A:
9.7		 6dm1A-3cg1A:
14.53
6dm1D-3cg1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3cg1 UPF0100 PROTEIN
PF0080
(Pyrococcus
furiosus) 		5 / 12 ILE A 186
LEU A 172
GLY A 163
PHE A 154
ILE A 199
 None
 1.04A 6qxsB-3cg1A:
undetectable		 6qxsB-3cg1A:
22.77