SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 8 ILE A  86
LEU A  30
GLU A 293
VAL A 285
 None
 0.72A 1a29A-3cg3A:
undetectable		 1a29A-3cg3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 GLU A 114
VAL A 116
ILE A 117
ILE A 139
PHE A 119
 None
 1.13A 1c9hA-3cg3A:
undetectable		 1c9hA-3cg3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 LEU A 216
LEU A 219
VAL A 220
SER A 222
LEU A 140
 None
 1.05A 1db1A-3cg3A:
undetectable		 1db1A-3cg3A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 11 SER A  37
THR A 214
ILE A 117
ILE A 115
VAL A 116
 WO4  A 701 (-2.4A)
None
None
None
None
 1.25A 1pkvA-3cg3A:
undetectable
1pkvB-3cg3A:
undetectable		 1pkvA-3cg3A:
15.29
1pkvB-3cg3A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 11 ILE A 115
VAL A 116
SER A  37
THR A 214
ILE A 117
 None
None
WO4  A 701 (-2.4A)
None
None
 1.28A 1pkvA-3cg3A:
undetectable
1pkvB-3cg3A:
undetectable		 1pkvA-3cg3A:
15.29
1pkvB-3cg3A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		3 / 3 LEU A 216
LEU A 219
SER A 224
 None
 0.68A 1tlmA-3cg3A:
undetectable		 1tlmA-3cg3A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 6 ARG A 206
ILE A 117
LEU A 245
TYR A 172
 None
 1.03A 2ya7A-3cg3A:
undetectable		 2ya7A-3cg3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 6 ARG A 206
ILE A 117
LEU A 245
TYR A 172
 None
 1.02A 2ya7B-3cg3A:
undetectable		 2ya7B-3cg3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 6 ARG A 206
ILE A 117
LEU A 245
TYR A 172
 None
 1.03A 2ya7D-3cg3A:
undetectable		 2ya7D-3cg3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 7 ILE A  32
LYS A  48
LYS A 309
GLY A 307
 None
 1.25A 3sj0X-3cg3A:
undetectable		 3sj0X-3cg3A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 9 ILE A 176
LEU A 180
ILE A 139
PHE A 147
GLY A 148
 None
 1.41A 3sj4X-3cg3A:
undetectable		 3sj4X-3cg3A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 11 THR A  78
LEU A  94
VAL A  89
VAL A 285
THR A 284
 None
 1.39A 3tbgA-3cg3A:
undetectable		 3tbgA-3cg3A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 VAL A 220
ASN A 113
TYR A 281
SER A 233
LEU A 240
 None
 1.34A 4a84A-3cg3A:
undetectable		 4a84A-3cg3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 11 GLU A 114
VAL A 116
ILE A 117
ILE A 139
PHE A 119
 None
 1.25A 4drjA-3cg3A:
undetectable		 4drjA-3cg3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 11 SER A 141
TRP A 136
PRO A 175
MET A 165
ALA A 168
 None
 1.49A 4hwkA-3cg3A:
0.0		 4hwkA-3cg3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 8 ILE A  86
ALA A 295
GLU A 331
VAL A 328
 None
 0.78A 4jltA-3cg3A:
undetectable		 4jltA-3cg3A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 10 TYR A 159
LEU A  94
LEU A  38
ALA A  35
GLY A 282
 None
None
None
WO4  A 701 (-2.9A)
None
 1.23A 4rn6A-3cg3A:
undetectable		 4rn6A-3cg3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 7 ASN A 288
LYS A 287
LEU A  30
PHE A  63
 None
 1.20A 4yv5B-3cg3A:
undetectable		 4yv5B-3cg3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 GLY A 173
TYR A 260
ILE A 279
THR A 244
PHE A 259
 None
 1.09A 4zdyA-3cg3A:
undetectable		 4zdyA-3cg3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 6 ALA A  73
SER A  37
ASP A 155
PRO A 156
 None
WO4  A 701 (-2.4A)
WO4  A 701 (-2.8A)
WO4  A 701 (-3.7A)
 1.16A 5c6pA-3cg3A:
undetectable		 5c6pA-3cg3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		3 / 3 TYR A 242
LYS A 236
LYS A 232
 None
 1.15A 5dbyA-3cg3A:
undetectable		 5dbyA-3cg3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 GLY A 173
TYR A 260
ILE A 279
THR A 244
PHE A 259
 None
 1.06A 5eskA-3cg3A:
undetectable		 5eskA-3cg3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 7 TYR A 195
MET A 163
THR A 273
ILE A 274
 None
 0.94A 5murB-3cg3A:
undetectable		 5murB-3cg3A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 10 TYR A 195
ILE A 194
MET A 163
THR A 273
ILE A 274
 None
 1.21A 5mzrA-3cg3A:
undetectable		 5mzrA-3cg3A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 8 ILE A 139
LEU A 140
LEU A 180
MET A 129
 None
 0.80A 5u4sB-3cg3A:
undetectable		 5u4sB-3cg3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 CYH A 157
LEU A 245
ILE A 117
PHE A 149
SER A 150
 None
 1.24A 5uanB-3cg3A:
undetectable		 5uanB-3cg3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 4 VAL A 116
ASN A 250
LYS A 232
TYR A 231
 None
None
None
WO4  A 701 (-4.3A)
 1.22A 5yf0A-3cg3A:
0.7		 5yf0A-3cg3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_ACTB502_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		4 / 4 VAL A 116
ASN A 250
LYS A 232
TYR A 231
 None
None
None
WO4  A 701 (-4.3A)
 1.20A 5yf0B-3cg3A:
0.7		 5yf0B-3cg3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 GLY A 173
TYR A 260
ILE A 279
THR A 244
PHE A 259
 None
 1.07A 6e8qA-3cg3A:
undetectable		 6e8qA-3cg3A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 11 ILE A 296
LEU A 299
LEU A 286
ILE A 100
MET A  99
 None
 1.44A 6fgcA-3cg3A:
undetectable		 6fgcA-3cg3A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3cg3 UPF0100 PROTEIN
PH0151
(Pyrococcus
horikoshii) 		5 / 12 PRO A 321
LEU A 303
GLY A 304
ASN A 305
ILE A 332
 None
 1.06A 6qxsB-3cg3A:
undetectable		 6qxsB-3cg3A:
23.50