SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ALA A 148
VAL A 153
TRP A 152
 None
NHE  A 196 ( 4.6A)
None
 0.92A 1c4dA-3cggA:
undetectable
1c4dB-3cggA:
undetectable		 1c4dA-3cggA:
12.50
1c4dB-3cggA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 TRP A 152
ALA A 148
VAL A 153
 None
None
NHE  A 196 ( 4.6A)
 0.93A 1c4dA-3cggA:
undetectable
1c4dB-3cggA:
undetectable		 1c4dA-3cggA:
12.50
1c4dB-3cggA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ALA A 148
VAL A 153
TRP A 152
 None
NHE  A 196 ( 4.6A)
None
 0.88A 1c4dC-3cggA:
undetectable
1c4dD-3cggA:
undetectable		 1c4dC-3cggA:
12.50
1c4dD-3cggA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  51
GLY A  53
GLY A 145
ILE A 144
ILE A  59
 None
NHE  A 195 (-3.2A)
None
NHE  A 195 ( 4.5A)
None
 1.01A 1c6zA-3cggA:
undetectable		 1c6zA-3cggA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  55
ASP A  76
LEU A  79
ASP A  96
 NHE  A 195 (-3.2A)
None
None
None
NHE  A 195 (-4.3A)
 0.74A 1qaoA-3cggA:
10.5		 1qaoA-3cggA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 5 LEU A  63
ASP A  51
GLY A 145
ALA A  36
ILE A  59
 None
 1.48A 2aohB-3cggA:
undetectable		 2aohB-3cggA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 144
ALA A 142
ALA A 135
LEU A  97
ILE A 102
 NHE  A 195 ( 4.5A)
None
None
NHE  A 195 (-3.8A)
EDO  A 200 (-4.4A)
 1.06A 2h77A-3cggA:
undetectable		 2h77A-3cggA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  51
GLY A  53
GLY A  55
ASP A  76
LEU A 120
 None
NHE  A 195 (-3.2A)
None
None
EDO  A 197 (-4.0A)
 0.91A 2nxeA-3cggA:
16.6		 2nxeA-3cggA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  51
GLY A  53
GLY A 145
ILE A 144
ILE A  59
 None
NHE  A 195 (-3.2A)
None
NHE  A 195 ( 4.5A)
None
 1.07A 2qhcB-3cggA:
undetectable		 2qhcB-3cggA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 GLY A  55
ASP A  74
ASP A  96
LEU A  97
 None
NHE  A 195 (-3.6A)
NHE  A 195 (-4.3A)
NHE  A 195 (-3.8A)
 0.56A 2uyqA-3cggA:
10.7		 2uyqA-3cggA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ASP A  51
GLY A  53
GLY A 145
ILE A 144
ILE A  59
 None
NHE  A 195 (-3.2A)
None
NHE  A 195 ( 4.5A)
None
 1.05A 2z54A-3cggA:
undetectable		 2z54A-3cggA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 PHE A 146
ASN A 115
PHE A 186
 None
 0.94A 2zbuD-3cggA:
undetectable		 2zbuD-3cggA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASN A  24
ASP A  86
GLN A  85
 None
 0.64A 3eeyC-3cggA:
14.2		 3eeyC-3cggA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASN A  24
ASP A  86
GLN A  85
 None
 0.65A 3eeyD-3cggA:
14.1		 3eeyD-3cggA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ASN A  24
ASP A  86
GLN A  85
 None
 0.64A 3eeyE-3cggA:
14.2		 3eeyE-3cggA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 144
ALA A 142
ALA A 135
LEU A  97
ILE A 102
 NHE  A 195 ( 4.5A)
None
None
NHE  A 195 (-3.8A)
EDO  A 200 (-4.4A)
 1.04A 3gwsX-3cggA:
undetectable		 3gwsX-3cggA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  61
GLY A  60
ALA A  83
ILE A  49
PRO A  88
 None
 1.07A 3jayA-3cggA:
undetectable		 3jayA-3cggA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
ILE A  59
ASP A  74
LEU A  75
ASP A  96
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
NHE  A 195 (-3.7A)
NHE  A 195 (-4.3A)
 0.98A 3q87B-3cggA:
13.6		 3q87B-3cggA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 ALA A 142
ILE A 132
LEU A 166
ALA A 189
 None
NHE  A 195 ( 4.9A)
None
None
 0.89A 3r9sA-3cggA:
undetectable		 3r9sA-3cggA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 ALA A 142
ILE A 132
LEU A 166
ALA A 189
 None
NHE  A 195 ( 4.9A)
None
None
 0.86A 3r9sC-3cggA:
undetectable		 3r9sC-3cggA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 GLY A  55
ASP A  74
ASP A  76
ASP A  96
LEU A 120
 None
NHE  A 195 (-3.6A)
None
NHE  A 195 (-4.3A)
EDO  A 197 (-4.0A)
 0.83A 3v8vB-3cggA:
5.9		 3v8vB-3cggA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 ASP A  51
GLY A  53
GLY A  55
ILE A  59
ASP A  74
 None
NHE  A 195 (-3.2A)
None
None
NHE  A 195 (-3.6A)
 0.47A 4dcmA-3cggA:
12.0		 4dcmA-3cggA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  55
ASP A  74
LEU A  75
ALA A 113
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
NHE  A 195 (-3.7A)
None
 0.61A 4lg1A-3cggA:
13.6		 4lg1A-3cggA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  55
ASP A  74
LEU A  79
ALA A 113
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
None
None
 0.91A 4lg1A-3cggA:
13.6		 4lg1A-3cggA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  55
ASP A  74
LEU A  75
ALA A 113
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
NHE  A 195 (-3.7A)
None
 0.61A 4lg1C-3cggA:
13.2		 4lg1C-3cggA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  55
ASP A  74
LEU A  79
ALA A 113
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
None
None
 0.97A 4lg1C-3cggA:
13.2		 4lg1C-3cggA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 4 ASP A  51
GLY A  55
ASP A  74
ASP A  96
 None
None
NHE  A 195 (-3.6A)
NHE  A 195 (-4.3A)
 1.07A 5e72A-3cggA:
16.2		 5e72A-3cggA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 PHE A 119
LEU A 120
ARG A 150
GLY A 151
 None
EDO  A 197 (-4.0A)
None
None
 1.10A 5o4yA-3cggA:
undetectable		 5o4yA-3cggA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A  71
LEU A  50
SER A 103
ALA A 135
 None
None
EDO  A 200 ( 2.7A)
None
 0.75A 5uunA-3cggA:
undetectable		 5uunA-3cggA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  60
ASP A  74
LEU A  75
ASP A  96
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
NHE  A 195 (-3.7A)
NHE  A 195 (-4.3A)
 0.98A 5yniA-3cggA:
7.8		 5yniA-3cggA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
GLY A  60
ASP A  74
LEU A  75
ASP A  96
 NHE  A 195 (-3.2A)
None
NHE  A 195 (-3.6A)
NHE  A 195 (-3.7A)
NHE  A 195 (-4.3A)
 0.97A 5ynmA-3cggA:
8.0		 5ynmA-3cggA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  50
LEU A  97
ALA A 128
GLY A 165
LEU A 166
 None
NHE  A 195 (-3.8A)
NHE  A 195 ( 4.5A)
None
None
 1.10A 6b0iB-3cggA:
undetectable		 6b0iB-3cggA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3cgg SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  53
ASP A  74
ASP A  76
ASP A  96
LEU A 120
 NHE  A 195 (-3.2A)
NHE  A 195 (-3.6A)
None
NHE  A 195 (-4.3A)
EDO  A 197 (-4.0A)
 1.02A 6bq4A-3cggA:
11.1		 6bq4A-3cggA:
15.90