SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A 295
THR A  66
ASP A  97
GLY A  71
 None
 1.02A 1bu5B-3cghA:
undetectable		 1bu5B-3cghA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 322
ALA A 297
VAL A 328
 None
 0.93A 1c4dC-3cghA:
undetectable
1c4dD-3cghA:
undetectable		 1c4dC-3cghA:
5.00
1c4dD-3cghA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 145
GLY A  71
ASP A  67
 None
 0.51A 1kf6A-3cghA:
2.2
1kf6B-3cghA:
1.1		 1kf6A-3cghA:
23.09
1kf6B-3cghA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 251
ASN A 459
LEU A 462
LEU A 368
VAL A  56
 None
 1.35A 1mrlB-3cghA:
undetectable
1mrlC-3cghA:
undetectable		 1mrlB-3cghA:
18.57
1mrlC-3cghA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 292
THR A 291
VAL A 349
ASN A 277
ALA A 273
 None
ZN  A 600 ( 4.6A)
None
None
None
 1.13A 1nv8A-3cghA:
undetectable		 1nv8A-3cghA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 298
VAL A 328
TRP A 322
 None
 0.90A 1tkqB-3cghA:
undetectable		 1tkqB-3cghA:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 100
SER A 114
TYR A 113
 None
None
ACT  A   1 ( 4.7A)
 0.59A 1x70A-3cghA:
undetectable		 1x70A-3cghA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 521
ASP A 525
ALA A 516
ILE A 517
 None
 0.89A 2aofB-3cghA:
undetectable		 2aofB-3cghA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 521
ASP A 525
ALA A 516
ILE A 517
 None
 0.82A 2aohB-3cghA:
undetectable		 2aohB-3cghA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  76
GLY A  71
GLY A 463
ALA A 466
PHE A  65
 None
 1.10A 2dpmA-3cghA:
undetectable		 2dpmA-3cghA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 471
GLY A 151
PRO A 152
 None
 0.58A 2hreD-3cghA:
undetectable		 2hreD-3cghA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A  78
LEU A  69
ILE A 351
VAL A 101
VAL A  56
 None
 1.06A 2pnjB-3cghA:
undetectable		 2pnjB-3cghA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A 171
THR A 147
ALA A 149
ARG A 471
 None
 1.22A 2qhfA-3cghA:
undetectable		 2qhfA-3cghA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 470
ALA A 468
PHE A  78
ASN A 464
LEU A  70
 None
 1.34A 3aobC-3cghA:
undetectable		 3aobC-3cghA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A 420
ALA A 422
THR A 424
ARG A 332
ALA A  79
 None
 1.08A 3g88A-3cghA:
undetectable		 3g88A-3cghA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A 420
ALA A 422
THR A 424
ARG A 332
ALA A  79
 None
 1.09A 3g88B-3cghA:
undetectable		 3g88B-3cghA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 420
ALA A 422
THR A 424
ARG A 332
ALA A  79
 None
 1.04A 3g89A-3cghA:
undetectable		 3g89A-3cghA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A 420
ALA A 422
THR A 424
ARG A 332
ALA A  79
 None
 1.04A 3g89B-3cghA:
undetectable		 3g89B-3cghA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 420
ALA A 422
THR A 424
ARG A 332
ALA A  79
 None
 1.06A 3g8bA-3cghA:
undetectable		 3g8bA-3cghA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 420
ALA A 422
THR A 424
ARG A 332
ALA A  79
 None
 1.07A 3g8bB-3cghA:
undetectable		 3g8bB-3cghA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 304
TYR A 308
TYR A 407
PHE A 396
 None
 1.17A 3ku9B-3cghA:
0.9		 3ku9B-3cghA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 486
GLY A 488
SER A 492
 None
 0.69A 3loqA-3cghA:
undetectable		 3loqA-3cghA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A 135
LEU A 112
ASN A 115
LEU A 116
VAL A 119
 None
None
None
ACT  A   1 ( 4.1A)
None
 0.68A 3o02A-3cghA:
3.9
3o02B-3cghA:
3.5		 3o02A-3cghA:
20.31
3o02B-3cghA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A  72
ASP A  67
PRO A  94
THR A  88
 None
 0.72A 4eyrB-3cghA:
undetectable		 4eyrB-3cghA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 407
PHE A 316
ARG A 312
 None
 1.16A 4g19D-3cghA:
undetectable		 4g19D-3cghA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A 459
TRP A 456
ILE A 301
TRP A 460
 None
 1.22A 4ii8A-3cghA:
undetectable		 4ii8A-3cghA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ASN A 433
ALA A 430
SER A 432
TYR A 308
 None
 1.14A 4ijiF-3cghA:
undetectable		 4ijiF-3cghA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 151
ARG A 471
ILE A 517
ALA A 516
ALA A 524
 None
 1.11A 4kicA-3cghA:
undetectable		 4kicA-3cghA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 357
ALA A 466
PHE A  78
LEU A  69
VAL A 349
 None
 1.27A 4nc3A-3cghA:
undetectable		 4nc3A-3cghA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A  47
ASN A  50
LEU A  51
 None
 0.51A 5i1nC-3cghA:
undetectable		 5i1nC-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A  47
ASN A  50
LEU A  51
 None
 0.38A 5i1nB-3cghA:
undetectable		 5i1nB-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A  47
ASN A  50
LEU A  51
 None
 0.44A 5i1oA-3cghA:
undetectable		 5i1oA-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A  47
ASN A  50
LEU A  51
 None
 0.44A 5i1pD-3cghA:
undetectable		 5i1pD-3cghA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 251
ALA A 142
ALA A 141
VAL A 137
GLY A  53
 None
 1.33A 5igpA-3cghA:
undetectable		 5igpA-3cghA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 149
PHE A 317
ILE A 302
GLY A 348
THR A  66
 None
 1.31A 5jlcA-3cghA:
undetectable		 5jlcA-3cghA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLN A 461
GLY A 463
ASP A 469
ASP A 148
 None
 0.92A 5vlmH-3cghA:
0.8		 5vlmH-3cghA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  71
GLY A 463
ALA A 466
ILE A  89
LEU A  70
 None
 1.14A 6b3bA-3cghA:
undetectable		 6b3bA-3cghA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3cgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 113
GLN A 157
GLU A 181
ALA A 142
 ACT  A   1 ( 4.7A)
None
None
None
 1.11A 6djzB-3cghA:
undetectable		 6djzB-3cghA:
17.29