SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.31A 1jhoA-3cgwA:
4.0		 1jhoA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.31A 1jhrA-3cgwA:
2.8		 1jhrA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.31A 1jhyA-3cgwA:
3.6		 1jhyA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.31A 1l4nA-3cgwA:
2.9		 1l4nA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.31A 1l5kA-3cgwA:
3.4		 1l5kA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.32A 1l5lA-3cgwA:
3.2		 1l5lA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.31A 1l5mA-3cgwA:
undetectable		 1l5mA-3cgwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 12 TYR A 252
THR A  10
GLY A   9
ILE A 202
LEU A 188
 None
 1.11A 1r30A-3cgwA:
undetectable		 1r30A-3cgwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 12 TYR A 252
THR A  10
GLY A   9
ILE A 202
LEU A 188
 None
 1.11A 1r30B-3cgwA:
undetectable		 1r30B-3cgwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		4 / 5 PRO A 194
PRO A 200
ILE A 165
TYR A 251
 None
 1.16A 2jkjD-3cgwA:
undetectable		 2jkjD-3cgwA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		4 / 5 PRO A 194
PRO A 200
ILE A 165
TYR A 251
 None
 1.16A 2jkjF-3cgwA:
undetectable		 2jkjF-3cgwA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		3 / 3 LEU A  26
GLU A  19
ILE A  20
 None
 0.52A 3czhA-3cgwA:
undetectable		 3czhA-3cgwA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  13
PRO A  45
GLY A   6
GLY A 190
LEU A 188
 None
 1.19A 3e23A-3cgwA:
undetectable		 3e23A-3cgwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 12 LEU A  13
PRO A  45
GLY A   7
GLY A 190
LEU A 188
 None
 1.19A 3e23A-3cgwA:
undetectable		 3e23A-3cgwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		4 / 6 VAL A 216
ILE A 202
ILE A 187
LEU A 188
 None
 0.72A 3hegA-3cgwA:
undetectable		 3hegA-3cgwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		3 / 3 PRO A 128
SER A 174
ASN A 125
 None
 0.79A 3lslG-3cgwA:
undetectable		 3lslG-3cgwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 12 PRO A 237
GLY A 240
ASP A 268
MET A 246
PHE A 272
 None
 1.44A 3r24A-3cgwA:
undetectable		 3r24A-3cgwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		4 / 7 ILE A 222
PRO A 221
GLY A 199
ALA A 232
 None
 0.91A 4g0uB-3cgwA:
undetectable		 4g0uB-3cgwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 9 THR A  10
GLY A   9
GLY A  16
LEU A  14
SER A 292
 None
 1.34A 4kqiA-3cgwA:
2.8		 4kqiA-3cgwA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		4 / 9 ALA A  94
LEU A 119
LEU A 116
ILE A 102
 None
 0.88A 4xtaA-3cgwA:
undetectable		 4xtaA-3cgwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 10 GLY A 167
VAL A 134
VAL A 168
SER A 130
LEU A 204
 None
 1.33A 4yb6C-3cgwA:
undetectable
4yb6F-3cgwA:
undetectable		 4yb6C-3cgwA:
21.47
4yb6F-3cgwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 10 SER A 130
LEU A 204
GLY A 167
VAL A 134
VAL A 168
 None
 1.32A 4yb6A-3cgwA:
undetectable
4yb6D-3cgwA:
undetectable		 4yb6A-3cgwA:
21.47
4yb6D-3cgwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3cgw LPPG:FO
2-PHOSPHO-L-LACTATE
TRANSFERASE
(Methanosarcina
mazei) 		5 / 10 SER A 130
LEU A 204
GLY A 167
VAL A 134
VAL A 168
 None
 1.32A 4yb6D-3cgwA:
undetectable
4yb6E-3cgwA:
undetectable		 4yb6D-3cgwA:
21.47
4yb6E-3cgwA:
21.47