SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 11 ASN A 221
LEU A 197
THR A 214
PHE A  38
HIS A  37
 None
 1.24A 1tw4A-3cgxA:
undetectable		 1tw4A-3cgxA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 6 PRO A 116
ILE A 112
ASN A 204
LEU A 200
 None
 0.97A 2wekB-3cgxA:
2.9		 2wekB-3cgxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 11 MET A 175
LEU A 183
ILE A 134
TYR A 168
GLN A 184
 None
 1.14A 3elzB-3cgxA:
undetectable		 3elzB-3cgxA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 PHE A 157
PHE A 147
LYS A 149
GLY A 101
 None
 0.94A 3em0B-3cgxA:
undetectable		 3em0B-3cgxA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 10 TYR A 143
ILE A 145
TYR A 168
ILE A 134
ALA A 133
 None
 1.45A 3u6tA-3cgxA:
undetectable		 3u6tA-3cgxA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 8 VAL A 106
VAL A 105
ILE A   6
CYH A   5
ASP A  52
 None
 1.17A 3wzeA-3cgxA:
undetectable		 3wzeA-3cgxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		3 / 3 ARG A 219
ASP A  41
GLN A  40
 None
 0.82A 4azsA-3cgxA:
undetectable		 4azsA-3cgxA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 ALA A 133
LEU A 144
TYR A 143
LEU A 185
 None
 0.90A 4iomA-3cgxA:
undetectable		 4iomA-3cgxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 8 ALA A 133
LEU A 144
TYR A 143
LEU A 185
 None
 0.89A 4jjkA-3cgxA:
undetectable		 4jjkA-3cgxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 VAL A 191
LEU A 218
MET A  42
THR A 214
 None
 1.05A 5e4dA-3cgxA:
undetectable
5e4dB-3cgxA:
undetectable		 5e4dA-3cgxA:
17.77
5e4dB-3cgxA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 12 TYR A  35
VAL A 191
LEU A 200
SER A 212
LEU A  72
 IMD  A 242 (-3.8A)
None
None
None
None
 1.18A 5hbsA-3cgxA:
undetectable		 5hbsA-3cgxA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		4 / 7 SER A 212
THR A 214
PRO A 113
ILE A 112
 None
 1.22A 5vkqA-3cgxA:
undetectable
5vkqB-3cgxA:
undetectable		 5vkqA-3cgxA:
9.57
5vkqB-3cgxA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 11 VAL A 105
SER A   2
ASP A 100
ALA A  97
LEU A   7
 None
 1.00A 5x6yA-3cgxA:
1.9		 5x6yA-3cgxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3cgx PUTATIVE
NUCLEOTIDE-DIPHOSPHO
-SUGAR TRANSFERASE
(Desulfovibrio
alaskensis) 		5 / 11 VAL A 105
SER A   2
ASP A 100
ALA A  97
LEU A   7
 None
 1.09A 5x6yC-3cgxA:
undetectable		 5x6yC-3cgxA:
14.55