SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3cgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ
(Salmonella
enterica) 		5 / 11 SER A 372
LEU A 338
ILE A 412
HIS A 409
ALA A 403
 None
 1.42A 2a58A-3cgyA:
undetectable
2a58E-3cgyA:
undetectable		 2a58A-3cgyA:
23.26
2a58E-3cgyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ
(Salmonella
enterica) 		5 / 11 ILE A 412
HIS A 409
ALA A 403
SER A 372
LEU A 338
 None
 1.42A 2a58C-3cgyA:
undetectable
2a58D-3cgyA:
undetectable		 2a58C-3cgyA:
23.26
2a58D-3cgyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ
(Salmonella
enterica) 		4 / 7 ALA A 471
ASP A 416
GLY A 470
GLY A 420
 RDC  A 700 (-3.3A)
RDC  A 700 (-3.1A)
None
RDC  A 700 (-4.1A)
 0.74A 2c49B-3cgyA:
undetectable		 2c49B-3cgyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ
(Salmonella
enterica) 		5 / 10 ILE A 401
ILE A 367
PHE A 373
VAL A 475
LEU A 348
 None
 1.21A 3elzB-3cgyA:
1.5		 3elzB-3cgyA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ
(Salmonella
enterica) 		5 / 12 GLY A 385
ILE A 412
VAL A 399
VAL A 341
ILE A 367
 None
 1.04A 4q5mA-3cgyA:
undetectable		 4q5mA-3cgyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3cgy VIRULENCE SENSOR
HISTIDINE KINASE
PHOQ
(Salmonella
enterica) 		5 / 12 GLU A 415
ALA A 471
GLY A 470
SER A 466
LEU A 447
 None
RDC  A 700 (-3.3A)
None
None
RDC  A 700 (-3.9A)
 1.11A 5w7pA-3cgyA:
undetectable		 5w7pA-3cgyA:
18.45