SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ch0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 5 LEU A  39
TYR A 132
ARG A 169
THR A  38
 None
 0.99A 1nw3A-3ch0A:
undetectable		 1nw3A-3ch0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 5 MET A 183
ALA A 179
ILE A 136
ASP A 155
 None
None
None
EDO  A 280 ( 4.3A)
 1.19A 1upfA-3ch0A:
2.0		 1upfA-3ch0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		3 / 3 GLU A 135
HIS A  13
GLU A  40
 CIT  A 272 (-2.9A)
CIT  A 272 (-3.9A)
CIT  A 272 (-3.6A)
 0.61A 2x45B-3ch0A:
undetectable		 2x45B-3ch0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		3 / 3 GLU A 135
HIS A  13
GLU A  40
 CIT  A 272 (-2.9A)
CIT  A 272 (-3.9A)
CIT  A 272 (-3.6A)
 0.65A 2x45C-3ch0A:
undetectable		 2x45C-3ch0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 8 THR A 171
GLN A 173
GLN A 131
SER A 193
 None
CIT  A 272 ( 4.5A)
EDO  A 285 (-3.0A)
None
 0.83A 2xz5C-3ch0A:
undetectable
2xz5D-3ch0A:
undetectable		 2xz5C-3ch0A:
22.86
2xz5D-3ch0A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		5 / 12 PHE A 268
PRO A   5
ASP A 219
THR A 221
LEU A 252
 None
None
EDO  A 275 ( 2.7A)
EDO  A 274 (-3.0A)
None
 1.22A 3iv6A-3ch0A:
undetectable		 3iv6A-3ch0A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		3 / 3 ARG A 102
ASP A  42
GLN A  11
 GOL  A 289 (-2.7A)
CIT  A 272 (-3.7A)
None
 0.76A 3lcvB-3ch0A:
undetectable		 3lcvB-3ch0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 6 PHE A 170
TYR A 132
VAL A  51
PHE A  41
 None
 1.32A 3ltwA-3ch0A:
undetectable		 3ltwA-3ch0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 8 GLU A  62
GLN A 106
ARG A 102
PHE A 103
 EDO  A 273 (-3.0A)
None
GOL  A 289 (-2.7A)
None
 0.84A 3mjrD-3ch0A:
undetectable		 3mjrD-3ch0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 8 SER A 105
ASP A 266
LEU A 267
ASP A 263
 EDO  A 286 (-3.9A)
None
None
EDO  A 279 (-4.4A)
 1.08A 3n2oC-3ch0A:
7.2
3n2oD-3ch0A:
9.6		 3n2oC-3ch0A:
17.57
3n2oD-3ch0A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 6 THR A 171
GLN A 173
GLN A 131
SER A 193
 None
CIT  A 272 ( 4.5A)
EDO  A 285 (-3.0A)
None
 0.88A 3peoG-3ch0A:
undetectable		 3peoG-3ch0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		3 / 3 ASP A 219
ARG A 102
THR A 221
 EDO  A 275 ( 2.7A)
GOL  A 289 (-2.7A)
EDO  A 274 (-3.0A)
 0.87A 4i13A-3ch0A:
undetectable		 4i13A-3ch0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		3 / 3 LEU A  33
LYS A  30
THR A  29
 None
EDO  A 284 ( 3.6A)
None
 0.63A 4lj0A-3ch0A:
undetectable		 4lj0A-3ch0A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		3 / 3 ASP A 219
ARG A 102
THR A 221
 EDO  A 275 ( 2.7A)
GOL  A 289 (-2.7A)
EDO  A 274 (-3.0A)
 0.84A 4p3rA-3ch0A:
undetectable		 4p3rA-3ch0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 5 SER A 105
ARG A  14
GLY A  15
GLU A  40
 EDO  A 286 (-3.9A)
GOL  A 289 ( 2.8A)
None
CIT  A 272 (-3.6A)
 1.14A 5btiC-3ch0A:
undetectable
5btiD-3ch0A:
undetectable		 5btiC-3ch0A:
20.60
5btiD-3ch0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		4 / 5 ARG A  14
ASP A 263
PHE A 103
ARG A 102
 GOL  A 289 ( 2.8A)
EDO  A 279 (-4.4A)
None
GOL  A 289 (-2.7A)
 1.50A 6hxiD-3ch0A:
undetectable		 6hxiD-3ch0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Cytophaga
hutchinsonii) 		5 / 12 ILE A 136
TYR A  83
ASP A 155
ASN A 149
ALA A 159
 None
None
EDO  A 280 ( 4.3A)
None
EDO  A 281 (-3.9A)
 1.26A 6r2eH-3ch0A:
undetectable		 6r2eH-3ch0A:
20.48