SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ch4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_B_SAMB1500_0 (ASPARTOKINASE)	3ch4	PHOSPHOMEVALONATE KINASE (Homo sapiens)	4 / 7	SER B 31 ARG B 32 LEU B 181 GLU B 178	None	0.92A	2cdqB-3ch4B: undetectable	2cdqB-3ch4B: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HC4_A_VDXA525_2 (VITAMIN D RECEPTOR)	3ch4	PHOSPHOMEVALONATE KINASE (Homo sapiens)	4 / 7	LEU B 13 LEU B 12 SER B 190 TYR B 122	None	1.25A	2hc4A-3ch4B: undetectable	2hc4A-3ch4B: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z90_F_4LEF401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	3ch4	PHOSPHOMEVALONATE KINASE (Homo sapiens)	4 / 8	LEU B 105 LEU B 184 THR B 26 LEU B 29	None MPD B 204 ( 4.3A) None None	0.63A	4z90F-3ch4B: undetectable 4z90G-3ch4B: undetectable 4z90H-3ch4B: undetectable 4z90I-3ch4B: undetectable 4z90J-3ch4B: undetectable	4z90F-3ch4B: 18.63 4z90G-3ch4B: 18.63 4z90H-3ch4B: 18.63 4z90I-3ch4B: 18.63 4z90J-3ch4B: 18.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CDQ_B_SAMB1500_0","ASPARTOKINASE","3ch4","PHOSPHOMEVALONATE KINASE","Homo sapiens",4,"SER B  31;ARG B  32;LEU B 181;GLU B 178","None","0.92A","2cdqB-3ch4B:undetectable","2cdqB-3ch4B:18.75"],["2HC4_A_VDXA525_2","VITAMIN D RECEPTOR","3ch4","PHOSPHOMEVALONATE KINASE","Homo sapiens",4,"LEU B  13;LEU B  12;SER B 190;TYR B 122","None","1.25A","2hc4A-3ch4B:undetectable","2hc4A-3ch4B:21.33"],["4Z90_F_4LEF401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","3ch4","PHOSPHOMEVALONATE KINASE","Homo sapiens",4,"LEU B 105;LEU B 184;THR B  26;LEU B  29","None;MPD B 204 ( 4.3A);None;None","0.63A","4z90F-3ch4B:undetectable;4z90G-3ch4B:undetectable;4z90H-3ch4B:undetectable;4z90I-3ch4B:undetectable;4z90J-3ch4B:undetectable","4z90F-3ch4B:18.63;4z90G-3ch4B:18.63;4z90H-3ch4B:18.63;4z90I-3ch4B:18.63;4z90J-3ch4B:18.63"]]