SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3chl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 6 ARG A 198
ILE A 111
PHE A 239
GLU A 275
 None
 1.45A 1nsiA-3chlA:
undetectable
1nsiB-3chlA:
undetectable		 1nsiA-3chlA:
21.17
1nsiB-3chlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 6 PHE A 239
GLU A 275
ARG A 198
ILE A 111
 None
 1.47A 1nsiA-3chlA:
undetectable
1nsiB-3chlA:
undetectable		 1nsiA-3chlA:
21.17
1nsiB-3chlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 6 PHE A 249
VAL A 105
LEU A 109
ALA A 246
 None
 0.98A 2e1qA-3chlA:
undetectable		 2e1qA-3chlA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 6 PHE A 249
VAL A 105
LEU A 109
ALA A 246
 None
 0.97A 2e1qC-3chlA:
undetectable		 2e1qC-3chlA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 ARG A 198
ILE A 111
PHE A 239
GLU A 275
 None
 1.45A 2nsiA-3chlA:
undetectable
2nsiB-3chlA:
undetectable		 2nsiA-3chlA:
21.17
2nsiB-3chlA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 ARG A 198
ILE A 111
PHE A 239
GLU A 275
 None
 1.45A 3e7gA-3chlA:
undetectable
3e7gB-3chlA:
undetectable		 3e7gA-3chlA:
22.00
3e7gB-3chlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 ARG A 198
ILE A 111
PHE A 239
GLU A 275
 None
 1.42A 3e7gC-3chlA:
undetectable
3e7gD-3chlA:
undetectable		 3e7gC-3chlA:
22.00
3e7gD-3chlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 8 PHE A 239
GLU A 275
ARG A 198
ILE A 111
 None
 1.46A 3e7gC-3chlA:
undetectable
3e7gD-3chlA:
undetectable		 3e7gC-3chlA:
22.00
3e7gD-3chlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 TYR A 212
TYR A 208
PHE A 201
TYR A 196
 None
 1.19A 3ku9B-3chlA:
undetectable		 3ku9B-3chlA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 PHE A 249
VAL A 105
LEU A 109
ALA A 246
 None
 1.01A 3uniA-3chlA:
undetectable		 3uniA-3chlA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 GLY A 301
VAL A 302
ILE A 307
PHE A 255
 None
 0.89A 4fglC-3chlA:
undetectable		 4fglC-3chlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 ARG A 198
ILE A 111
PHE A 239
GLU A 275
 None
 1.45A 4nosC-3chlA:
undetectable
4nosD-3chlA:
undetectable		 4nosC-3chlA:
21.82
4nosD-3chlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 7 ILE A 111
VAL A 253
ILE A 268
PHE A 249
 None
 0.93A 5hieC-3chlA:
undetectable		 5hieC-3chlA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		5 / 8 LYS A 308
ALA A 306
ASP A 292
PHE A 291
PHE A 255
 None
 1.47A 5mvsB-3chlA:
undetectable		 5mvsB-3chlA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		4 / 6 ASP A 200
ARG A 160
LEU A 204
ASP A 168
 None
 0.96A 5tdzA-3chlA:
undetectable		 5tdzA-3chlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		3 / 3 GLU A 230
HIS A 237
VAL A 221
 None
 0.89A 5trqB-3chlA:
undetectable		 5trqB-3chlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		5 / 11 GLY A 259
ASP A 261
TYR A 303
CYH A 295
ILE A 307
 None
 1.40A 6agoA-3chlA:
undetectable		 6agoA-3chlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		3 / 3 LEU A  32
LEU A  67
ARG A  29
 None
 0.58A 6fgcA-3chlA:
undetectable		 6fgcA-3chlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3chl ALPHA-14 GIARDIN
(Giardia
intestinalis) 		3 / 3 LEU A  32
LEU A  67
ARG A  29
 None
 0.57A 6fgdA-3chlA:
undetectable		 6fgdA-3chlA:
20.23